Abha Saxena

Dedicated and skilled educator with a strong background in programming and data processing seeks to leverage my diverse expertise to enhance student learning and foster a collaborative classroom environment. I am enthusiastic about using my experience in data modeling to support curriculum development and promote effective practices among students.

• Systems biology: Mathematical modeling of cell signaling network, single cell and population model, kinetic parameter sensitivity analysis, parameter estimation, Monte-Carlo simulation.
• Optimization- local and global optimization. Nature inspired optimizations (genetic algorithm, simulated annealing algorithm, etc), Hybrid optimization.
• Statistical data analysis: large scale biological data analysis, statistical distribution fitting, hypothesis testing, goodness of fit, maximum likelihood, regression, hypothesis testing, model selection, K-L divergence, Akaike information criterion.
• Machine Learning and data analysis: Principal component analysis, data clustering.
• Softwares - MS- OFFICE, Adobe illustrator, image J (image analysis software), Origin (Data analysis and graphical software), MATLAB

ODE modelling, QSP modelling, PKPD modelling, Non-liner dynamics, Monte Carlo simulation, Data-driven modelling, Parametric sensitivity, Parameter estimation, Hybrid optimization, Nature-inspired algorithm, Genetic algorithm, Hybrid optimization, Graph theory, Data clustering, Large-scale data analysis, Statistical distribution, Hypothesis testing, Regression analysis, Model selection, Maximum likelihood estimates, IBD/CD/UC, Leaky Gut/IBS, PCOD, Diabetes, Liver metabolism, Subclinical inflammation, Rheumatoid Arthritis

Date of Birth: 01/10/89

• A systems biology-based mathematical model demonstrates the potential anti-stress effectiveness of a multi-nutrient botanical formulation, Sci Rep (Nature), 2024, https://doi.org/10.1038/s41598-024-60112-8, 4.3
• Efficacy of optimal nutraceutical combination in treating PCOS characteristics: an in-silico assessment, BMC Endocr Disord, 2024, 10.1186/s12902-024-01571-y, 38549084, PMC10979615
• Effect of oral nutrition supplement on growth in preschool children–a systems physiology-based in silico analysis: Effect of ONS on growth in preschool children, Indian Journal of Child Health, 2022, https://doi.org/10.32677/ijch.v9i11.3696
• A Detailed Model and Monte Carlo Simulation for Predicting DIP Genome Length Distribution in Baculovirus Infection of Insect Cells, Biotechnology and Bioengineering, 2020, 10.1002/bit.27566, 4.54
• Statistical modeling of cell‐to‐cell variability in viral infection during passaging in suspension cell culture: Application in Monte‐Carlo simulation, Biotechnology and Bioengineering, 2020, 10.1002/bit.27295, 4.54
• A structured review of baculovirus infection process: integration of mathematical models and biomolecular information on cell–virus interaction, Journal of General Virology, 2018, 10.1099/jgv.0.001108, 3.56
• Isolation and Screening of biosurfactant producing bacteria from polluted lake, Journal of Advanced Biotechnology & Bioinformatics, 2013
• Bioethanol production by Zymomonas mobilis MTCC No. 2427 using orange peels as low cost substrates, Chem Tech Res, 2013

 International Conference Publications

• Gare Suman, Soumita Chel, Devi Priyanka, Abha Saxena, KIshalay Mitra, RahulDeb Sarar, Lopamudra Giri. “Analytics Pipeline for Visualization of Single Cell RNA Sequencing Data from Brochoaveolar Fluid in COVID-19 Patients: Assessment of Neuro Fuzzy-C-Means and HDBSCAN” 2022 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). DOI: 10.1109/EMBC48229.2022.9871686
• Surbhi Sharma, Abha Saxena, Soumita Chel, Kishalay Mitra, Lopamudra Giri. “Mathematical modelling of viral infection dynamics and immune response in SARS-Cov2: A computational framework for testing drug efficacy”. 2021 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). DOI:10.1109/EMBC46164.2021.9630629
• Gare Suman, Abha Saxena, Lopamudra Giri. “Confocal Imaging of Intercellular Calcium in HeLa Cells for Monitoring Drug-Response: Biophysical Framework for Visualization of the Time-Lapse Images”. 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), DOI: 10.1109/ISBI45749.2020.909869
• Abha Saxena, Vaibhav Dhyani, Soumya Jana, Lopamudra Giri. “Application of kohonen-self organizing map to cluster drug induced Ca2+ response in hippocampal neurons at different drug dose”. 2020 National Conference on Communications (NCC), IEEE. DOI: 10.1109/NCC48643.2020.9056031
• Abha Saxena, Vaibhav Dhyani, Suman Gare, Lopamudra Giri. “Effect of topology and time window on probability distribution underlying baclofen induced Ca2+ response in hippocampal neurons”, 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). DOI: 10.1109/EMBC.2019.8857601
• Abha Saxena, Vikas Upadhyay, Vaibhav Dhyani, Soumya Jana, Lopamudra Giri. “Cellto-Cell Variability in Protein Expression during Viral Infection: Monte-Carlo Simulation and Validation based on Confocal Imaging”, 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). DOI: 10.1109/EMBC.2019.8856612
• Ranjana Singh, Abha Saxena, Lopamudra Giri. “Single Neuron Imaging Reveals Metabotropic Glutamate Receptor-Mediated Bursting and Delay in Calcium Oscillation in Hippocampal Neurons”, 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). DOI: 10.1109/EMBC.2019.8856638

• Dr. Lopamudra Giri, Department of Chemical Engineering, Indian Institute of Technology, Hyderabad, (+91)-40-23017024, giril@iith.ac.in
• Dr. Kishalay Mitra, Department of Chemical Engineering, Indian Institute of Technology, Hyderabad, (+91)-40-23017055, kishalay@iith.ac.in
• Dr. Soumya Jana, Department of Chemical Engineering, Indian Institute of Technology, Hyderabad, (+91)-40-2301-6105, jana@iith.ac.in
• Prof. David W. Murhammer, Dept. of Chemical and Biochemical Engineering, University of Iowa, Iowa City, 52242, USA, david-murhammer@uiowa.edu
• Dr. Jayanta Chakraborty, Department of Chemical Engineering, IIT, Kharagpur, West-bengal, jayanta@che.iitkgp.ac.in

Presented papers and poster at “41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)” held in Berlin, Germany.

• First rank holder in M.Tech.
• DST-INSPIRE fellowship, IIT, Hyderabad, 2015