PALLAVI CHOUDANTE

As a recent graduate with a Ph.D. in Science, I am passionate about research and have a strong background in in vitro and in vivo biology. My research expertise lies in the development of tin-loaded mesoporous silica nanoparticles as a potent anticancer agent against breast cancer cells and its toxicity studies. I have developed strong skills in maintaining cell cultures, including both animal and human cancer cell lines. Additionally, I have a proven track record of publications in high-impact factor journals. I am eager to contribute my scientific writing skills and research experience to a dynamic and innovative team.

• In vitro Skills, Culture maintenance of various animal and human cancer cell lines such as B16F10, CHO, HEK, MCF-7, DU145, SKOV3, etc., MTT-based cytotoxicity assay., Annexin V binding-based Apoptosis assay., Cellular uptake studies., Cell cycle study., TUNEL assay., ROS assay by DCFDA and confocal., Scratch assay, in vitro genotoxicity studies (Chromosomal aberration assay, micronucleus assay, mitotic index)
• In vivo/ Ex vivo, Establishing xenographic breast tumor models in BALB/c mice., Blood collection from mice and Intravenous (i.v.), Intraperitoneal (i.p.) injections., In vivo bio-distribution studies., Cell cycle studies, Histopathology studies., Immunohistochemistry, ROS studies, Serum biochemical analysis, Bone marrow collection, Observation of the in-vitro and in-vivo chromosomes and micronucleus, Ex vivo: Harvesting the spleen, lung, heart, liver, kidney, brain and solid tumors., CAM assay, Survivability studies under therapeutic settings using mouse tumor models
• Scientific writing, An experienced scientific writer with a passion for publishing research in high-impact factor journals. Published numerous articles in journals such as Biomaterials Advances (Impact Factor 8.4), Journal of Drug Delivery Science and Technology (Impact Factor 5) and Journal of Natural Products (Impact Factor 4.8).
• Training to Lab Juniors, Experienced trainer with expertise in cell culture-based techniques and in-vitro and in-vivo studies. During my PhD, I trained to M. Pharma and MSc. Biotech dissertation students from UCPSC Warangal and GITAM University, providing them with hands-on training and guidance to master various laboratory techniques. Developed training programs to enhance their technical skills in cell culture, in-vitro assays, in-vivo experiments, and other relevant laboratory procedures.

• Dr. Sunil Misra, Thesis Supervisor, Applied Biology Division, CSIR-IICT, Hyderabad, smisra@iict.res.in, +91-9441439010
• Dr. Sidhanath Vishwanath Bhosale, Sr. Principal Scientist, Polymers & Functional Materials, CSIR-IICT, Hyderabad, bhosale@iict.res.in, +91-9490065673
• Dr. Chitta Ranjan Patra, Sr. Principal Scientist, Applied Biology Division, CSIR-IICT, Hyderabad, crpatra@iict.res.in, +91-9666204040

• Tin-loaded mesoporous silica nanoparticles: Antineoplastic properties and genotoxicity assessment, Biomaterials Advances, 137, 212819, 8.4, P. C. Choudante, S. K. Nethi, D. Díaz-García, S. Prashar, S. Misra, S. Gómez-Ruiz, C. R. Patra, 2022-01-01. Impact factor 8.4
• Functionalized tinloaded mesoporous silica nanoparticles for targeted therapy of triple-negative breast cancer: Evaluation of cytogenetic toxicity, Journal of Drug Delivery Science and Technology, 94, 105502, 5, Pallavi C. Choudante, Jhansi Mamilla, Lalithya Kongari, Diana Díaz-García, Sanjiv Prashar, Santiago Gomez-Ruiz, Sunil Misra, 2024-01-01. Impact factor 5
• Design, Synthesis, Molecular Docking and Biological Evaluation of 1-(benzo[d]thiazol-2- ylamino) (phenyl) methyl)naphthalen-2-ol Derivatives as Antiproliferative Agents, Letters in Organic Chemistry, 16, 10, 2019, 10.2174/1570178616666190408101233, Sandhya Jonnala, Bhaskar Nameta, Murthy Chavali, Rajashaker Bantu, Pallavi Choudante, Sunil Misra, B. Sridhar, S. Dilip, B.V. Subba Reddy
• Usnic acid enaminone-coupled 1, 2, 3- triazoles as antibacterial and antitubercular agents, Journal of natural products, 83, 1, 26-35, 4.8, P. K. Bangalore, S. K. Vagolu, R. K. Bollikanda, D. K. Veeragoni, P. C. Choudante, S. Misra, ..., S. Kantevari, 2019-01-01. Impact factor 5.1
• Synthesis of Novel Thiazolidine-4-One Derivatives, Their Cytotoxicity, Antifungal Properties, Molecular Docking and Molecular Dynamics, Russian Journal of Bioorganic Chemistry, 10.1134/S1068162023020127, U B Kosurkar, Jhansi Mamilla, T L Dadmal, P. C. Choudante, S. Misra, 2023-01-01