Experienced Application Scientist with a robust background in biotechnology, specializing in Upstream & Downstream Development, recombinant protein production, post transnational modification (PTM), and enzyme activity analysis. I have successfully optimized cost-effective enzyme production techniques with advanced Upstream innovations. Skilled in project management and laboratory practices, I excel at leading teams, driving process improvements, and achieving impactful results. Fascinated about Research and Development which create impact to building butter society.
Hi, I’m
Arindam Jana
Bhubaneswar
Summary
Overview
7
years of professional experience
1
Certification
8
years of post-secondary education
Work History
KIIT UniversityBhubaneswar
Ph.D Student
09.2019 - Current
Job overview
- Institute Overview: School of Biotechnology, KIIT-DU, Bhubaneswar, India.
- Website: https://biotech.kiit.ac.in/
- I am pursuing my research activity under Dr. Rahul Modak's supervision and Dr. Amrita Mishra's co-supervision.
- Project Title: Production, Purification, and Characterization of a Novel Deacetylase Enzyme (VcCobB) in E. Coli under high cell-density culture conditions.
- Also working on L-asparaginase enzyme's food application to reduce acrylamide content in fried or baked foods.
Description:
My research focuses on advancing recombinant protein production using E. coli as a host system. In our study, we uncovered histone modifications associated with Vibrio cholerae infection and demonstrated the role of a bacterial deacetylase, VcCobB, in deacetylating eukaryotic histones.
Furthermore, we optimized high cell density culture conditions and implemented an efficient scale-up strategy using chemically defined media. By refining cell lysis and protein purification techniques, we achieved maximum protein yield while minimizing production costs. The recombinant protein was thoroughly characterized, culminating in comparative analyses of enzyme activity and potential applications.
KIIT-TBI, Bioprocess FacilityBhubaneswar
Application Scientist
12.2017 - Current
Job overview
- Company Overview: KIIT Technology Business Incubator, KIIT-DU, Bhubaneswar.
- Website: https://kiitincubator.in/bioprocess-facility/
- Responsibilities:
- Operate bioreactor (New Brunswick BioFlo/Celligen 115, Eppendorf) for biomass production in different culture conditions.
- Purification techniques optimization for different enzyme production using AKTA Pure FPLC, Cytiva.
- Prototyping operation strategy for startup projects (protein biology).
- DoE for scaling up and scaling down processes for recombinant protein production.
- Overall maintenance of the common instrumentation facility.
- Prepare data and information for process development.
- Provide bioprocess services to the institute or industry.
- Design the enzyme assay, and optimize the enzyme formulation and application.
IIT DelhiDelhi
Participant
07.2022 - 07.2022
Job overview
- DBT sponsors the National Biopharma Mission (NBM) Hands-on Training Programme on Bioprocessing for Biopharmaceuticals.
Education
KIIT School of Biotechnology, KIIT UniversityBhubaneswar
M.Sc Biotechnology from GPA: CGPA- 7.54
07.2016 - 05.2018
University Overview
The KIIT School of Biotechnology (KSBT) is a premier institute under the aegis of Kalinga Institute of Industrial Technology (KIIT Deemed to be University) in Bhubaneswar, Odisha. Renowned for its state-of-the-art infrastructure, cutting-edge research facilities, and an environment that fosters innovation, KSBT has emerged as a hub for biotechnology education and research in India.
Established with a vision to produce highly skilled professionals and contribute significantly to biotechnology research, KSBT offers undergraduate, postgraduate, and doctoral programs.
Vidyasagar UniversityWest Bengal
BSc Microbiology from GPA: Percentage- 55.75%
08.2013 - 04.2016
University Overview
Vidyasagar University, located in the historic town of Midnapore in West Bengal, is a renowned state university established in 1981 in honor of the eminent social reformer and educationist Pandit Ishwar Chandra Vidyasagar. Guided by his values of knowledge dissemination and societal upliftment, the university is committed to fostering excellence in education and research.
The university campus, nestled in a serene environment, provides an ideal setting for academic pursuits. It offers various undergraduate, postgraduate, and doctoral programs across diverse disciplines, including humanities, science, commerce, social sciences, and professional studies. Vidyasagar University aims to balance traditional academic excellence with emerging fields of study to cater to the evolving needs of students and society.
West Bengal Council of Higher Secondary EducationGhoshpur High School, WB, India
Higher Secondary (12th) from GPA: Percentage- 64.4%
07.2011 - 04.2013
University Overview
The West Bengal Council of Higher Secondary Education (WBCHSE) is the apex body responsible for overseeing and regulating higher secondary education (Class XI and XII) in West Bengal. Established under the West Bengal Council of Higher Secondary Education Act, 1975, the council plays a pivotal role in shaping the academic framework for higher secondary studies in the state.
West Bengal Board of Secondary EducationGhoshpur High School, WB, India
Secondary (10th) from GPA: Percentage- 68.88%
06.2009 - 05.2011
University Overview
The West Bengal Board of Secondary Education (WBBSE) is the authoritative body responsible for managing and regulating secondary education (Class IX and X) in the state of West Bengal. Established in 1951 under the West Bengal Secondary Education Act, the board has played a crucial role in shaping the educational landscape of the state by ensuring access to quality education and promoting academic excellence at the secondary level.
Skills
- Team Leading
- Project Management
- Lab Indents Organizer
- Laboratory Practices
- Efficient Knowledge Acquisition
- Basic Computer Skills
- Word, Excel
Technical skills
Technical skills
I have extensive experience operating bioreactors with live monitoring and real-time data analysis using BioCommand software, complemented by proficiency in high-capacity ultra-centrifugation for large-scale applications. My expertise includes advanced protein purification techniques such as affinity chromatography, gel permeation chromatography (GPC), and desalting, with live monitoring and data analysis capabilities using UNICORN7 software. I excel in designing and optimizing chromatography programs, bioreactor parameters, and methods for batch and fed-batch fermentation processes. Additionally, I have successfully optimized recombinant protein production, performed diverse enzyme activity assays, and conducted detailed enzyme kinetics studies to enhance functional understanding.
Publications
Publications
- Arindam Jana, Soumyajit Biswas, Ritu Ghosh, Rahul Modak*; Food Chemistry: X Journal; "Recent advances in L-Asparaginase enzyme production and formulation development for acrylamide reduction during food processing". (https://doi.org/10.1016/j.fochx.2024.102055)
- Shibangini Beura, Pulak Pritam, Ajit Kumar Dhal, Arindam Jana, Aishwarya Dash, Pritisundar Mohanty, Alok Kumar Panda, Rahul Modak* ; Front. Mol. Biosci. Journal; "An insight into role of N-terminal domain of Salmonella enterica CobB in oligomerization and Zn 2+ mediated inhibition of deacetylase activity". (https://doi.org/10.3389/fmolb.2024.1345158)
- Arindam Jana, Pragyan Mishra, Ritu Ghosh, Rahul Modak*; "Production and characterization of Vc1509, a NAD+ dependent deacetylase from Vibrio cholerae in E. coli under high cell density culture conditions". (Manuscript under preparation)
- Arindam Jana, Sounak Bagh, Rahul Modak*; "Cost effective L-Asparaginase enzyme production and lyophilized formulation development for acrylamide reduction in baked food". (Research work done.)
- Arindam Jana, Shreyashree Pal, Snehasish Mshra, Rahul Modak*; Book Chapter; "A 360º understanding of vaccine design and production: Prospects and challenges". (Manuscript submited)
Certification
- Certified Bioprocess professional by NBM, Department of Biotechnology, Government of India.
Affiliations
Affiliations
- 10th Annual Meeting of Chemical Biology Society (India), Kalinga
Institute of Industrial Technology, KIIT-DU, Bhubaneswar, India, March
24-25, 2023. (Poster presentation)
91st Annual Meeting of the Society of Biological Chemists, Kolkata
chapter, Bose Institute, Kolkata, India, December 8-11, 2022. (Poster
presentation)
Accomplishments
Accomplishments
- KIIT Fest 2024 Mismatch (cooking contest) secured 1st position.
- KIIT Fest 2024 Kwaste (creative art using waste material) secured 1st position.
- KIIT Fest 2023 Waste to Good contest, secured 1st position.
Languages
Bengali
First Language
English
Proficient (C2)
C2
Hindi
Advanced (C1)
C1
References
References
- Dr. Rahul Modak, Associate Professor, Associate R & D Dean, KIIT School of Biotechnology, KIIT-DU, Bhubaneswar, India, rahul.modak@kiitbiotech.ac.in
- Dr. Amrita Mishra, Associate Professor, KIIT School of Biotechnology, KIIT-DU, Bhubaneswar, India, amrita.mishra@kiitbiotech.ac.in
Disclaimer
Disclaimer
I, hereby, declare that the above information provided is true and to the best of my knowledge., Bhubaneswar, 21/12/24
Timeline
Participant
IIT Delhi
07.2022 - 07.2022
Ph.D Student
KIIT University
09.2019 - Current
Application Scientist
KIIT-TBI, Bioprocess Facility
12.2017 - Current
KIIT School of Biotechnology, KIIT University
M.Sc Biotechnology from GPA: CGPA- 7.54
07.2016 - 05.2018
Vidyasagar University
BSc Microbiology from GPA: Percentage- 55.75%
08.2013 - 04.2016
West Bengal Council of Higher Secondary Education
Higher Secondary (12th) from GPA: Percentage- 64.4%
07.2011 - 04.2013
West Bengal Board of Secondary Education
Secondary (10th) from GPA: Percentage- 68.88%
06.2009 - 05.2011
- Certified Bioprocess professional by NBM, Department of Biotechnology, Government of India.
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