Datta Darshan V M

I am a computational biologist with expertise in molecular dynamics simulations. My research focuses on understanding the structural and functional consequences of disease-related single nucleotide polymorphisms (SNPs) and point mutations in proteins. I utilize advanced simulation techniques to investigate how these genetic variations alter protein stability, dynamics, and interactions with other biomolecules, ultimately impacting cellular processes and disease pathogenesis. I am particularly interested in using this knowledge for protein engineering applications, such as designing therapeutic interventions, improving protein stability and function.

Certification in Generative AI by Growth School

1. V.M. Datta Darshan , Natarajan Arumugam, Abdulrahman I. Almansour, Venketesh Sivaramakrishnan, Subbarao Kanchi (2024) - In silico energetic and molecular dynamic simulations studies demonstrate potential effect of the point mutations with implications for protein engineering in BDNF. International Journal of Biological Macromolecules , Volume 271, Part 1, 2024, 132247, ISSN-0141-8130, https://doi.org/10.1016/j.ijbiomac.2024.132247. (IF: 8.5)

2. V. M. Datta Darshan , Sivaramakrishnan, V., & Arvind Kumar, K. (2023). Structural systems biology approach delineate the functional implications of SNPs in exon junction complex interaction network. Journal of Biomolecular Structure and Dynamics , 41(21), 11969–11986. https://doi.org/10.1080/07391102.2022.2164355 (IF: 3.2)

3. Natarajan Arumugam, Datta Darshan V. M ., Vishal Venketesh, Sai Sanwid Pradhan, Anuj Garg, Venketesh Sivaramakrishnan, Subbarao Kanchi, and Sakkarapalayam M. Mahalingam (2024) - Synthesis, computational docking and molecular dynamics studies of a new class of spiroquinoxalinopyrrolidine embedded chromanone hybrids as potent anti-cholinesterase agents RSC Advances 14, 18815-18831. 10.1039/D4RA02432J (IF: 3.9)

4. Sankar Ganesan, T., Elangovan, N., Thirumavalavan, M., Seenan, S., Sowrirajan, S., Chandrasekar, Datta Darshan V. M ., Sivaramakrishnan, V. (2024). - Synthesis, topology, molecular docking and dynamics studies of o-phenylenediamine derivative. Journal of Biomolecular Structure and Dynamics , 1–20. https://doi.org/10.1080/07391102.2024.2317981 (IF: 3.2)

5. Pradhan, S. S., R., Saiswaroop., Kanikaram, S. P., V.M. Datta Darshan ., Pargaonkar, A., Dandamudi, R. B., & Sivaramakrishnan, V. (2023). - Metabolic deregulation associated with aging modulates protein aggregation in the yeast model of Huntington's disease. Journal of Biomolecular Structure and Dynamics , 42(19), 10521–10538. https://doi.org/10.1080/07391102.2023.2257322 (IF: 3.2)

6. Srimadh Bhagavatham, S. K., Pulukool, S. K., Pradhan, S. S., R., S., Ashok Naik, A., V. M. Datta Darshan , & Sivaramakrishnan, V. (2022). Systems biology approach delineates critical pathways associated with disease progression in rheumatoid arthritis. Journal of Biomolecular Structure and Dynamics , 41(14), 6969–6990. https://doi.org/10.1080/07391102.2022.2115555 (IF: 3.2)

7. Swaroop, R.S., Pradhan, S.S., V.M. Datta Darshan, Venketesh Sivaramakrishnan*, - Integrated network pharmacology approach shows a potential role of Ginseng catechins and ginsenosides in modulating protein aggregation in Amyotrophic Lateral Sclerosis. (2022) 3 Biotech 12 , 333. https://doi.org/10.1007/s13205-022-03401-1 (IF: 2.9)

8. S. Skanda, P.S.J. Bharadwaj, V.M. Datta Darshan , Venketesh Sivaramakrishnan, B.S. Vijayakumar, (2022) - Proficient mycogenic synthesis of silver nanoparticles by soil derived fungus Aspergillus melleus SSS-10 with cytotoxic and antibacterial potency, Journal of Microbiological Methods , Volume 199, 2022, 106517, ISSN 0167-7012, https://doi.org/10.1016/j.mimet.2022.106517. (IF: 1.7)

9. Nishant Kumar Kolli, Datta Darshan V M , Dhivyaa Anandan, Venketesh Sivaramakrishnan, Amit Kumar Jaiswal, Siva Kumar Belliraj, Swarup Kundu and Santanu Roy (2022) - Probing into the potential features of sodium calcium silicate (Na2Ca2Si3O9) synthesized by the solid-state route. Physica Scripta, Volume 97, 8, 10.1088/1402-4896/ac7ae6 (IF: 2.3)

10. Bhagavatham, S.K.S., Kannan, V., V.M. Datta Darshan . et al. Nucleotides modulate synoviocyte proliferation and osteoclast differentiation in macrophages with potential implications for rheumatoid arthritis. (2021) 3 Biotech 11, 504 (2021). https://doi.org/10.1007/s13205-021-03052-8 (IF: 2.9)