Deekshi Angira
Summary
Dynamic and highly skilled postdoctoral researcher with a strong background in molecular biology, protein biochemistry, and structural biology. Experienced in conducting cutting-edge research and contributing to innovative advancements within challenging research environments. Seeking opportunities to apply expertise and contribute to the forefront of scientific discovery.
Overview
13
13
years of professional experience
1
1
Certification
Work History
Fulbright Nehru Postdoctoral Researcher
University of Texas Southwestern Medical Center
05.2022 - 05.2024
- Delving in the Era of Precision Medicine for Colorectal Cancer via KRASG13D Mutant as a Potential Target
- Advisor: Dr Kenneth Westover
- Contributed to and actively participated in research conception, design and execution to address defined problems.
- Conducted thorough literature reviews to inform experimental design and maintain awareness of current trends in the field.
- Presented research findings at international conferences, fostering knowledge exchange among peers.
- Established productive collaborations with interdisciplinary teams to address pressing scientific questions.
- Overcame technical challenges by troubleshooting equipment issues or refining experimental procedures as necessary.
Postdoctoral Researcher
Indian Institute of Science
03.2020 - 02.2022
- Biochemical Investigation of the res gene product in type III RM system of Helicobacter pylori
- Advisor: Prof Desirazu Narasimha Rao
Teaching Assistant
Indian Institute of Technology
07.2013 - 08.2019
- Conducted experimental demonstrations for B.Tech and M.Tech students, enhancing their practical understanding.
- Operated advanced equipment such as Circular Dichroism, FPLC protein purification systems, and Single Crystal X-ray diffraction instruments independently.
- Designed projects and mentored interns, contributing to their academic and professional growth.
Lecturer
Doon (PG) Paramedical College and Hospital
10.2011 - 07.2012
- Instructed B.Sc and M.Sc courses in Medical Laboratory Technology, Biotechnology, and Biochemistry, engaging an average of 30 students per class.
- Developed quizzes, examination papers, and home assignments for various courses, ensuring comprehensive assessment of student knowledge.
Research Intern
Auroprobe Research Laboratories
02.2011 - 04.2011
- To study the sensitivity of PCR, BACTEC 460 and ZN Staining for the detection of Mycobacterium Tuberculosis
Education
PhD - Chemistry (Molecular Biology and Protein Biochemistry)
Indian Institute of Technology Gandhinagar
Gandhinagar, Gujarat11-2019
M.Sc. - Biochemistry
Doon PG Paramedical College And Hospital
Dehradun, Uttarakhand09-2011
B. Sc. - Biotechnology
Vallabh Government College
Mandi, Himachal Pradesh04-2009
Skills
- Protein Biochemistry : Protein purification (membrane proteins included), refolding, crystallization, single-crystal X-ray diffraction, and data analysis for small molecules and proteins
- Analytical and Biophysical Techniques: Differential Scanning Fluorimetry (DSF), Analytical Size Exclusion Chromatography (SEC), Isothermal Titration Calorimetry (ITC), and biosensor development
- Molecular Biology Techniques: DNA/RNA extraction and purification, Real-Time PCR (RT-PCR), restriction-modification systems, and molecular modeling, including protein-inhibitor docking
- Cell Culture and Assay Development: Mammalian cell culture, enzymatic assay development, and NanoBiT/Alpha Screen assays for high-throughput screening
- Drug Discovery and Development: Expertise in drug-target interaction studies and biosensor-based drug screening platforms
- Crystallography and Structural Biology: Small molecule and protein crystallization, diffraction data collection, and analysis for inhibitor or drug complex characterization
- Immunological and Binding Assays: ELISA, DOT Blot Far Western, and Electrophoretic Mobility Shift Assay (EMSA)
- Advanced Screening and Detection Techniques: Alpha Screen Assay, NanoBiT, and radiometric detection methods for molecular interactions
Accomplishments
- Granted Fulbright Nehru Postdoctoral Fellowship 2021
- Granted DBT-RA Fellowship 2021
- Qualified CSIR-NET JRF-Life Science with AIR 70, 2013
- Qualified GATE- Life Science (96 percentile), 2013
- PDB Best Poster Award at 24th Congress and General Assembly of the International Union of Crystallography, Hyderabad, India, 2017
- Best Poster award at RSC West India Section Meeting of Research Scholars-2016, Gujarat, India, 2016
- Best Poster award at 3rd Nirma Institute of Pharmacy International Conference (NIPiCON-2016), Gujarat, India
Languages
English
Hindi
Training/ Workshop
- Fulbright Visiting Scholar Workshop on Scientific Manuscript Publishing & Peer Reviews, Fulbright Grant Training Center, 2024
- Virtual training for Visiting Fulbright Professional Grant Development Workshop, Fulbright and IIE, 2023
- Science Communication Workshop, Wellcome Trust/ DBT India alliance, 2017
- Workshop and training on Mammalian Cell Culture Techniques, NIPER Ahmedabad, Gujarat, 2017
Publications
- To Explore the Binding Affinity of Human γ-Secretase Activating Protein (GSAP) Isoform 4 with APP-C99 Peptides, Angira, D., Chaudhary, S., Abiramasundari, A., and Thiruvenkatam, V., ACS Omega, 8, 14, 13435-13443, 2023
- Structural and strategic landscape of PIKK protein family and their inhibitors: An overview, Angira, D., Shaik, A., and Thiruvenkatam, V., Frontiers in Bioscience, 25, 1538-1567, 2020
- Synthesis and characterization of a new class of phenothiazine molecules with 10H-substituted morpholine and piperidine derivatives: a structural insight, Hussain, J., Angira, D., Hans, T., Dubey, P., Kirubakaran, S., and Thiruvenkatam, V., Journal of Molecular Structure, 1219, 128546, 2020
- Characterization of P. Aeruginosa glucose 6-phosphate isomerase: a functional insight via in-vitro activity study, Angira, D., Natarajan, N., Dedania, S. R., Patel, D. H., and Thiruvenkatam, V., Current Topics in Medicinal Chemistry, 20, 29, 2651-2661, 2020
- Insights into supramolecular assembly formation of diethyl aryl amino methylene malonate (DAM) derivatives assisted via non-covalent interactions, Shaik, A., Angira, D., and Thiruvenkatam, V., Journal of Molecular Structure, 1192, 178-185, 2019
- Investigation of nicotinamide and isonicotinamide derivatives: A quantitative and qualitative structural analysis, Purushothaman, G., Angira, D., and Thiruvenkatam, V., Journal of Molecular Structure, 1197, 34-44, 2019
- Tracing the GSAP-APP C-99 interaction site in the β-amyloid pathway leading to Alzheimer's Disease, Angira, D., Chikhale, R., Mehta, K., Bryce, R. A., and Thiruvenkatam, V., ACS Chemical Neuroscience, 10, 8, 3868-3879, 2019
- Exploring a solvated dimer of Gefitinib: a quantitative analysis, Angira, D., Shaik, A., Kirubakaran, S., and Thiruvenkatam, V., Acta Crystallographica Section C: Structural Chemistry, 74, 8, 944-950, 2018
- Structural investigation and in-silico characterization of Plasmepsins from Plasmodium falciparum, Nair, D. N., Singh, V., Angira, D., and Thiruvenkatam, V., J. Proteom. Bioinform, 9, 181-195, 2016
- Induction of KRAS G13D dimers as a therapeutic strategy for colorectal cancer, Deekshi Angira, Lianbo Li, Zhiwei Zhou, Seungheon Lee, Joseph Ready, Kenneth Westover, Cancer Research, 03/15/24, 84, 6_Supplement, 1806, 10.1158/1538-7445.AM2024-1806
- Characterization of RAS assembly architectures in living cells, Zhou, Z., Li, X.-X., Meyer, C., Zhang, Y.-A., Angira, D., and Westover, K., Cancer Research, 04/01/23, 83, 2619, 10.1158/1538-7445.AM2023-2619
- Gamma secretase activating protein as profound target for Alzheimer's disease, Angira, D., and Thiruvenkatam, V., Acta Crystallographica Section A, 08/01/17, C1187, 10.1107/S2053273317083875
Personal Information
- Date of Birth: 07/01/88
- Nationality: Indian
- Marital Status: Married
Certification
- Completed ' Drug Discovery' an online non-credit course authorized by University of California San Diego and offered through Coursera.
- Completed ' Targets, Assays & Screening' an online non-credit course authorized by Novartis and offered through Coursera.
Timeline
Fulbright Nehru Postdoctoral Researcher
University of Texas Southwestern Medical Center
05.2022 - 05.2024
Postdoctoral Researcher
Indian Institute of Science
03.2020 - 02.2022
Teaching Assistant
Indian Institute of Technology
07.2013 - 08.2019
Lecturer
Doon (PG) Paramedical College and Hospital
10.2011 - 07.2012
Research Intern
Auroprobe Research Laboratories
02.2011 - 04.2011
- Completed ' Drug Discovery' an online non-credit course authorized by University of California San Diego and offered through Coursera.
- Completed ' Targets, Assays & Screening' an online non-credit course authorized by Novartis and offered through Coursera.
PhD - Chemistry (Molecular Biology and Protein Biochemistry)
Indian Institute of Technology Gandhinagar
M.Sc. - Biochemistry
Doon PG Paramedical College And Hospital
B. Sc. - Biotechnology
Vallabh Government College
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