Deepika Yadav

To seek and maintain full-time position that offers professional challenges utilizing interpersonal skills, excellent time management and problem-solving skills. Research oriented with computational aided drug designing with knowledge of bioinformatics tools and techniques, computational biology, statistical/machine learning based algorithms applications on chemical structures/data, pattern recognition.

• Awarded with ‘Senior research Fellowship’ of Indian Council of Medical Research (ICMR), New Delhi vide award letter no.-5/3/8/10/ITR-F/2018-ITR dated 09.04.2018-19.04.2020.
• Awarded as a Scholarship Winner to participate in 2019, 9th International Meeting, NextGen Genomics, Biology, and Bioinformatics and Technologies (NGBT) NGBT conference, 30th Sep-2nd Oct 2019, Mumbai.

• Molecular Modelling studies on proteasome inhibitors for Anticancer activity against NF-κB signaling pathway, 9th International SGRF Conferences, 2019 NextGen Genomics, Biology, and Bioinformatics and Technologies (2019 NGBT), 09/30/2019, 10/02/2019, Mumbai, India
• Molecular Modeling studies on Ursolic acid derivatives for Anticancer activity against T24 Bladder cell line targeting NF-κB signaling pathway, 6th International Symposium on “CURRENT TRENDS IN DRUG DISCOVERY & RESEARCH” (CTDDR-2019), 02/20/2019, 02/23/2019, Lucknow, India

• Research and Development: Bioinformatics In silico analysis
• Computer Aided Drug Design & Molecular Modeling
• Data Analysis & Predictive Modeling
• Quantitative Structure-Activity Relationship (CoMFA/3D and MLR/2D QSAR)
• Machine learning: Virtual Screening based Drug Discovery: Ligand based virtual screening of novel compounds: query generation and optimization, developed novel merged scaffold hybrid query, molecular docking based studies etc using Schrodinger (GLIDE, Protein Preparation Wizard, LigPrep, Phase, QikProp, Sitemap, Induced Fit Docking, CANVAS. KNIME), MTT based cytotoxic assays for experimental validation of identified leads.
• Topomer CoMFA model on Glide (docking tool), Phase (pharmacophore modeling tool), and Topomer CoMFA (QSAR tool).
• Pharmacokinetics analysis (ADME/T)
• Cancer Research Based Research (Biochemical Signalling Pathways).
• Docking and Simulation of Protein-ligand Interactions: Modeling and geometry optimization of protein-ligand complexes: Discovery Studio.
• Data science, Statistical Partial Least Squares Regression modeling
• Predictive Modeling for Chemical Properties/Structural Features and Biological Activities: Descriptor calculation (ChemoPy, PaDel, ChemDes tools); QSAR/QSPR/QSTR models for predicting chemical properties, reactivities and biological activities like ADMETox of diverse chemicals using advanced machine learning methods such as Multiple linear regression (MLR), Principal component regression (PCR), Linear and Nonlinear Partial least squares regression (PLSR), Artificial Neural Networks, Cheminformatics.
• Database similarity searching, FASTA, BLAST, Low-Complexity Regions. PSI-BLAST, PHI-BLAST.

• Attended one day hand on Training/ Workshop on “Structure Activity Relationship Studies for Lead Identification by using 3D QSAR Tool & Techniques” held at ‘CSIR-CIMAP’ Lucknow on 20th June 2016.
• Attended International Symposium on “Applicability of Genomics Technologies in Oncology & Constitutional Genetic Disorder” held at ‘KGMU’, Lucknow on 14th October 2016.
• Attended three days 7th International Symposium on “Current Trends in Drug Discovery Research” held at CSIR-CDRI, Lucknow, on 20th -23rd Feb 2019.
• Attended three days 9th International conference on “NextGen Genomics, Biology, Bioinformatics and Technologies 2019 NGBT”, held at Taj Lands End, Mumbai, on Sep 30th –Oct 2nd, 2019.

• Awarded as “Award of Excellence” in Poster Competition, Boston College for Professional Studies, Gwalior (M.P), 27th Feb, 2008 (M.Sc. Biotechnology).
• Awarded as “Second Prize winner, Poster completion, ‘Botanical Society’ , M.G. Post Graduate College, Gorakhpur, session 2006-2007
• Attended three days Seminar cum Workshop on “Recent trends in Molecular Biology and Immunology for Diagnosis and Prevention of Human Diseases, held at Boston College for Professional Studies, Gwalior (M.P.), on 02nd June- 14th June, 2008.
• Attended one day Seminar on “Recent Trends in Biotechnology”, held at Institute of Allied Sciences and computer Application, Department of Biotechnology & Microbiology, Gwalior (M.P.), on 10th May, 2008.
• Attended two days “Instructional Workshop on Bioinformatics”, Alcove Life Sciences, Bioinformatics Division, held at Department of Life sciences, Boston College for Professional Studies, Gwalior (M.P.), on 27th & 28th Jan 2008.
• Attended an International online webinar on “Emerging Trends in Bioinformatics: CADD & Machine Learning”, organised by Dr. Omics Labs on 3rd December 2023.

• Biochemistry, Biophysics and Microbiology
• Genetics, Molecular Biology and Immunology
• IPR Bioethics and Biosafety
• Genetic Engineering
• Bioinformatics
• Research & Methodology

• CADD SOFTWARE TOOL EXPOSURE
• Sybyl -X 2.1 (Docking, 3D, 2D QSAR)
• Schrodinger 10.5 & Glide (Pharmacophore modeling, QSAR, Docking using Glide)
• Discovery Studio 2.1 by Accelrys, USA
• Molecular Design Suite 3.5, Vlife Sciences
• Autodock, PyMol
• FlexX (Docking)
• Swiss-Model Builder
• Microsoft Office- Word & Excel
• Practical and basic knowledge of Python (Jupyter note, pandas, Anacondas etc.) & R

• Biophysical: UV-VIS Spectrophotometry
• Liquid chromatography (HPLC)
• Polymerase chain Reaction
• Tissue culture
• DNA-Nucleic Acid Interaction

 Goal oriented, Hard-working, Highly organized, Self-motivated and a Team player., Skilled, Adaptive and Proactive in any multicultural environment.

Quantitative Structure-Activity Relationship Analysis, Synthesis and In Vitro Evaluation of Brevifoliol Ester Derivatives as Anti-cancer Agents for Prostate Cancer Cell line Targeting NF-κB signaling.

Training with Gill Hospital Research Project’ in Collaboration with “Gachon University”, 02/03/2017, 04/24/2017, Sungkyunkwan University, South Korea

• Date of Birth: 10/23/88
• Gender: Female
• Nationality: Indian
• Marital Status: Married

• 3D-QSAR and docking studies on ursolic acid derivatives for anticancer activity based on bladder cell line T24 targeting NF-kB pathway inhibition, Journal of Biomolecular Structure and Dynamics, 37(14), 3822-3837, 2018
• Quantitative Structure-Activity Relationship and Molecular Docking Studies on Human Proteasome Inhibitors for Anticancer Activity Targeting NF-κB Signaling Pathway, Journal of Biomolecular Structure and Dynamics, 2019
• Synthesis and evaluation of substituted 8, 8-dimethyl-8H-pyrano chromen-2-one derivatives as vasorelaxing agents, Bioorganic & medicinal chemistry letters, 30(1), 126759, 2020
• Induced osteoblast differentiation by amide derivatives of stilbene: The possible osteogenic agents, Bioorganic & Medicinal Chemistry Letters, 127138, 2020

• Dr. Bhartendu Nath Mishra, Prof. & Head, Department of Biotechnology, Dean, Research & Development and Industrial Consultancy, Dr. A.P.J. Abdul Kalam Technical University (AKTU), Lucknow, 226021, India, 08795999945, profbnmishra@gmail.com
• Dr. Feroz Khan, Senior Principal Scientist & Head, Metabolic & Structural Biology Dept., CSIR- Central Institute of Medicinal & Aromatic Plants, Lucknow, 226015, India, 9415538701, f.khan@cimap.res.in
• Dr. Sarika Saxsena, Associate Professor, Amity University, Institute of Biotechnology, Noida, 201313, India, 9013865137, ssaxena1@amity.edu