As a holistic genetics researcher specializing in Human Genetics within Zoology, am dedicated to unraveling hereditary complexities and molecular intricacies. With extensive experience in genotyping, cytogenetics, and molecular biology, I study genetic variations impacting disease susceptibility and therapy responses. As a passionate educator, I foster inclusive learning environments, motivating students to achieve their best potential.
OCCUPATIONAL EXPOSURE TO COOKING OIL FUMES (COFS): BIOCHEMICAL, CYTOGENETIC AND MOLECULAR SIGNATURES
Occupational exposure to Cooking Oil Fumes (COFS) is a widespread concern in the culinary industry, and it has raised significant health apprehensions due to its potential adverse effects on individuals working in kitchens. This current research presents a comprehensive analysis of the biochemical, cytogenetic, and molecular analysis observed in individuals exposed to COFS in their workplace. The study employed a cross-sectional approach, involving a cohort of kitchen personnel working in diverse culinary settings. Biochemical assessments focused on analyzing blood parameters, such as lipid profiles, liver enzymes, and markers of oxidative stress, to gauge the impact of COFS on the participants' systemic health. Cytogenetic investigations encompassed the assessment of chromosomal aberrations and micronuclei frequency in peripheral blood lymphocytes, shedding light on potential genotoxicity associated with COF exposure. Moreover, molecular analyses involved the examination of ApoE and BMAL1 gene expression patterns related to inflammation, oxidative stress response, and detoxification pathways also this aspect aimed to uncover the underlying molecular mechanisms influenced by COFS. Preliminary results suggest a significant association between COF exposure and alterations in biochemical parameters, particularly an increase in oxidative stress markers and changes in lipid profiles, indicative of potential cardiovascular risks. Cytogenetic assessments revealed an elevated frequency of chromosomal aberrations and micronuclei formation, highlighting genotoxic effects linked to COF exposure. Molecular investigations demonstrated differential expression patterns of ApoE and BMAL1 genes involved in inflammation and oxidative stress responses, further corroborating the adverse effects of COFS on cellular processes. The findings of this research underscore the importance of addressing occupational exposure to COFs and implementing appropriate safety measures in cooking area. Additionally, this research contributes valuable insights into the biochemical, cytogenetic, and molecular alterations associated with COF exposure, potentially aiding in the development of preventive strategies and health interventions for individuals working in these environments. Further research is warranted to elucidate the long-term health implications and refine preventive measures in the culinary industry.