Dr Silpa S

PhD Scholar in Microbiology and Biotechnology with extensive hands-on experience in cell biology, biomaterial fabrication, and bioactive peptides. Expertise encompasses conducting cell culture experiments, optimizing nanofiber technologies, and evaluating therapeutic applications. Strong foundation in in vitro assays, wound healing research, and molecular biology techniques, demonstrating proven capability to collaborate within interdisciplinary teams, mentor students, and contribute to impactful research. Prepared to leverage skills to foster innovation within a prestigious organization.

• Writing
• Reading

• Silpa, S. and Rupachandra, S., 2024. Fabrication and in vitro characterization of nisin-incorporated PCL/PEG electrospun nanofibers for wound dressing applications. Polymer Bulletin, 81(14), pp.12655-12674.
• Sajan, S. and Saravanan, R., 2024. Identification and characterization of antibacterial peptides produced by Lactobacillus plantarum 1407, BioImpacts: BI, 14(6), p. 29912
• Silpa, S. and Rupachandra, S., 2022. Cyclic peptide production from lactic acid bacteria (LAB) and their diverse applications. Crit. Rev. Food Sci. Nutr, 62(11), pp.2909-2927.
• Silpa, S., Janet Bertilla, X. and Rupachandra, S., 2023. Emerging Trends, Challenges, and Opportunities in Protein Therapeutics. Protein-based Therapeutics, pp.297-324.
• Saravanan, P., R, P., Balachander, N., K, K.R.S., S, S. and S, R., 2023. Anti-inflammatory and wound healing properties of lactic acid bacteria and its peptides. Folia Microbiologica, 68(3), pp.337-353.
• Silpa, S., Bhattacharya, S. and Venkatanagaraju, E., 2017. Overview on L-asparaginase. World J Pharm Pharm Sci 2017; 6 (5): 561, 601.

• PhD Scholar |SRM Institute of Science and Technology, Department of Biotechnology, Chennai, India| December 2019 – July 2025

-Thesis: “Studies on the fabrication of novel electrospun nanofibers loaded with bioactive peptides of lactic acid bacteria for enhanced wound healing applications.” 

-Designed and optimized nanofiber scaffolds for wound healing applications, incorporating bioactive peptides, and assessing their biological efficacy in various cell culture models. 

-Conducted extensive in vitro experiments to evaluate anti-inflammatory and wound healing properties using mammalian cell lines, including RAW 264.7, L929, and HepG2. Assessed the wound healing efficacy of peptide-infused nanofibers in various in vivo animal models (rats and mice), providing insight into their therapeutic potential. 

• Analyzed cell viability, cytokine secretion, and gene expression to determine the therapeutic potential of peptide-loaded nanofibers,

-Mentored B.Tech and M.Tech students, providing guidance on experimental design, data analysis, and research methodologies, and presented research findings at international conferences, including ICMT-2023 and ICRIB-2023, receiving recognition for innovative applications in nanobiotechnology and biomaterials.

• MSc Project: Mutagenesis of Bacillus cereus for Enhanced Production of L Asparaginase: Optimization of culture media conditions under solid-state fermentation for antitumor application.
• Funded Project : KSCST funded project titled “A Novel Approach in Exploitation of Waste Agar Generated in Microbial and Tissue Culture Laboratory towards Production of Bioethanol”.
• BSc Project : Isolation and Identification of Pectinase-Producing Fungus using ITS sequencing for potential industrial applications

• Hands-on Training on "Basoc Techniques in Animal Handling and Research",SRM-DBT platform for advanced studies (2024).
• Hands-on Tarining on " Real-time PCR workshop on analysis of gene expression" , SRMIST (2023)
• International conference on Molecular Medicine and Therapeutics (ICMT-2023)– Poster presentation: “In vitro assessment of antioxidant and anti-inflammatory activity of bioactive peptide-loaded nanofibers.
• International Conference on Recent Innovations in Biotechnology (ICRIB-2023) – Oral presentation: “Assessment of in vitro wound healing activity of electrospun nanofibers loaded with bioactive peptides.”
• Hands-on workshop on Molecular Biology and Bioinformatics, UniBiosys Research Labs (2013).
• On-Job Training in Fisheries Post-Harvest Technology, NIFPHATT (2016)

 • Strong communication and interpersonal skills 

 • Team collaboration and leadership abilities

  • Problem-solving and critical thinking  

• Project management and organizational skills

• Date of Birth: April 29, 1994 | Nationality: Indian

 I hereby declare that the information provided is true to the best of my knowledge.  

Date:   

Place: Ernakulam