Summary
Skills
Work History
Education
Accomplishments
Publications (14): Patents (7) and Journals (7)
Volunteer

Dr. Syed Aziz Imam Quadri

Group Leader Teva India Ltd.
Delhi,DL

Summary

Following my deep passion for process chemistry for 16+ years by working with renowned synthetic API developers and competitors including Wockhardt, Sandoz, Watson, Actavis and Teva API in the area of Process Research & Development leading to Scale-up & Technology Transfer.

Skills

    Process Development and Scale up

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Work History

Group Leader (Chemical Researcher)

Teva Pharma
Greater Noida, National Capital Region
07.2016 - 07.2019
  • Responsible for leadership and technical expertise for all aspects of new and existing chemical process development, technology transfer, process scale-up, process monitoring, and process troubleshooting and optimization for complex API, highly potent APIs (oncology), Crystalline APIs and Oily API. Developed cost effective APIs.
  • Project wise Daily work planing and delegation to team.
  • Coordination and regular update with Global cross functional teams like IP, Regulatory associates, Sourcing, Toxicology team, MS&T, Production, Q.A and Analytical team.
  • Ensured compliance in complete Development of APIs.
  • Subject matter expert in DOE, implemented for screening and optimization of processes.
  • Screening the Process candidate for Flow chemistry.
  • Ensuring safety of process through understanding and interpreting the test results of process safety assessment and consequently adapting the process conditions. Additionally, leading and supporting the preparation of process safety information packages.
  • Sound knowledge and interpretation skills for Genotoxic impurities, nitrosoamine impurities and relevant report preparation.
  • Significant experience of quick analytical data interpretation and characterization through data of NMR, IR, UV, PXRD, HPLC, LCMS and GC.

Scientist III

Actavis Pharma
Mumbai, Maharashtra
04.2015 - 07.2016
  • Leading the team of multiple projects for selection of route of synthesis, feasibility study, process development and technology transfer to plant scale.
  • Ensuring safety of process through understanding and interpreting the test results of process safety assessment and consequently adapting the process conditions. Additionally, leading and supporting the preparation of process safety information packages.
  • Carrying out experiments and preparing presentation for weekly updates. Presenting periodic updates of projects to local and global team.
  • Prepared Development reports, safety reports and Genotoxic risk assessment reports.

Sr. Executive

Watson Pharmaceutical
mumbai, maharashtra
07.2012 - 03.2015
  • Leading the team for development of various complex projetcs , oncology projects, process scale up, validation and support for DMF filing.
  • Preparation of documentations and process packages like faesibility reports, Development report, process safety risk assesment report, Genotoxic reports.

Scientist III

Sandoz
mumbai, maharashtra
07.2008 - 06.2012
  • Involve in ROS selection, process development, scale up and technology transfer of complex APIs.
  • Daily planing and carrying out experimentation, record online with observations.
  • Interpetation of analytical data and decision making.
  • Developed various complex API and transfer to plant for scale up.
  • Adhering the safety norms and interpeting thermal hazards screening.
  • Cooridnation with cross functional local and global team.
  • Received regular class room learning for complience, functional competence and soft skills.

Research Associate

Wockhardt
Aurangabad, Maharashtra
04.2005 - 06.2008
  • Process development and scale up to plant scale for technology transfer and process validation.
  • Daily experiments planing and execution.
  • Learning literature search, patent assessment.
  • Preparation of process development reports.

Education

Ph.D. - Organic Chemistry

Dr. Babasaheb Ambedkar University
Maharastra
07.2013 - 12.2018

Master of Science - Organic Chemistry

Osmania University
03.2001 - 03.2003

Bachelor of Science - Chemistry, Biology

Osmania University
03.1997 - 03.2000

Accomplishments

Awards and Recognitions

  • . Teva Star Award, “Change the Phase of the Project for Roxadustat” (2019)
  • . Crescentino Spot Award, Pearl Award, Best Scientist Award for Development, Most Innovative Idea Award in Sandoz (2008-2012) Pharmaceuticals India for my significance contribution in process development.
  • .1st Winner of Patent Quiz for 4 consecutive years from 2008 to 2012 in Sandoz Pharmaceuticals India.

Publications (14): Patents (7) and Journals (7)

Seven International Peer Reviewed Journals (3 –Chemistry Select-Wiley Publisher, 1 – Synthetic communication, 1-LOC).

Seven PCT (One of the Innovator).

1) Luthra, Parven, Kumar; Ahmad, Suhail, Sinha Chandrasekhar, syed Aziz Imam Quadri; “ Process of Preparation of Roxadustat and Intermediate thereof”, WO/2021/026307 A1.

2) S. A. I. Quadri, T. C. Das, S. Jadhav, Mazahar Farooqui* “Efficient synthesis of tertiaryamine by direct N-alkylation of secondary amine with carboxylic acid using Ni (0) enact catalyst” Synthetic Communications 2018, 48, 3, 267-277. 9650694555

3) S.A.I. Quadri, T. C. Das, Prof. M. Farooqui* “Novel and Efficient Synthesis of Benzimidazole and Benzothiazole Moieties Mediated by Triflic Anhydride and 2-Nitropyridine” ChemistrySelect 2017, 2, 1802 – 1807.

4) S.A.I. Quadri, M. S. Malik, Z. S. Seddigi, Prof. M. Farooqui, “ Efficient Ferric Citrate catalysed synthesis of Novel Dihydropyrimidin-(1H)-ones Sulfonamide Conjugates and Their Evaluation as Potential Antimicrobials” ChemistrySelect 2017, 2, 6818 – 6822.

5) S.A.I. Quadri, T. C. Das, M. S. Malik, Z. S. Seddigi, Prof. M. Farooqui, “Itaconic Acid as Environmentally Benign Catalyst in Efficient and Scalable Synthesis of 3,4 – Dihydropyrimidin-2(1H)-ones” ChemistrySelect 2016, 1, 4602 – 4606.

6) T. C. Das, S. A. I. Quadri, Mazahar Farooqui*, “Efficient and Regioselective Synthesis of Phenothiazine via Ferric Citrate Catalyzded C-S/C-N Cross-Coupline” Letters in Organic Chemistry 2018, 16(1), 16-24.

7) T. C. Das, S. A. I. Quadri, S. Jadhav, Mazahar Farooqui* “Optimization of Imidazole Ring Formation Reaction Using DOE-Central Composite Design” DER PHARMA CHEMICA 2018, 10, 89-98.

8) T. C. Das, S. A. I. Quadri, S. Jadhav, Mazahar Farooqui* “Synthesis of new 2-substituted-10-phenylsulfonylphenothiazine conjugates and evaluation as anticancer agents by investigating their off-target mechanism” Chemistry & Biology Interface, 2018, 8, 84-93.

9) Parven Kumar Luthra; Chandrasekhar Sinha; Syed Aziz Imam Quadri; Tonmoy Chitta Das; “ Process of preparation of intermediates useful in synthesis of eluxadoline”. Pub. No. WO/2016/135756A1.

10) Arjun rajaram Bhodke; Sadanand Hardeo Maurya; Ravindra santosh patil; Sunil Baburao Jagtap; Syed Aziz Imam Quadri; “Preparation of sacubitril or salt thereof and novel intemediates in preparation of sacubitril”. WO/2016/2003500A3.

11) Zupancic, Borut; Luthra, Parven, Kumar; Khan, Rashid; Nair, Raji; Das, Tonmoy; Gudekar, Sanket; Syed, Aziz; “ Synthesis of 2-(3,4-difluorophenyl)cycloprpanamine derivatives and salts”, WO/2013/1444295.

12) Shreerang Joshi; Rashid Khan; Raji Nair; Syed Aziz Imam Quadri; “ Novel Intermediates for preparation of highly pure aprepitant or fosaprepitant” Pub. No. WO2012146692A1.

13) Joshi, Shrrerang; Khan, Rashid; Das, Tonmoy; Luthra, Parven, Kumar; Aziz Syed; “Process of preparation of fosaprepitant”. Pub. No. : WO/2011/045817 A3.

14) Syed Aziz Imam Quadri; Rafeeq Mohammed; Siddiqui Mohammed Jaweed Mukarram, “An improved process for preparation of pramipexole and salt thereof”. Pub. No.: WO/2008/104847 A3, International application number: PCT/IB2008/000406.

Dr. Syed Aziz Imam QuadriGroup Leader Teva India Ltd.