Dr Tirlangi Jagannadha Rao
Senior Principal Scientist
Hyderabad
Summary
To reach pinnacle in the chosen area for responsible and challenging position in the field of chemical industry by associating myself with growing organization that would provide me individual growth and development, in the process contributing for the betterment of the Organization.
Overview
15
15
years of professional experience
Work History
Senior Principal Scientist
Piramal Pharma Limited
09.2020 - Current
- Over 17 years of experience as a research scientist in Organic Synthesis.
- Successfully developed and executed number of synthesis routes for therapeutically active organic molecules ranging from milligrams to tons.
- Currently working as a Research Scientist, in Piramal Pharma Limited from September 2020 to till date.
- Worked as a senior scientist in Laxai Lifesciences Pvt Ltd, Hyderabad, India, from July 2019 to 2020 September.
- Worked as a Manager, Biophore India Pharmaceuticals Pvt Ltd, Hyderabad, India, from Aug 2017 to June 2019.
- Scientific Manager, GVK Biosciences, Hyderabad, India, from Dec 2013 - July 2017.
- Associate Research Scientist, Sai Life Sciences Ltd, Hyderabad, India, from April 2012 - Nov 2013.
- Evaluated new technologies for potential integration into existing research processes, driving continuous improvement efforts.
- Streamlined research processes to meet tight deadlines for multiple projects.
- Mentored junior scientists, fostering professional growth and enhancing team capabilities.
- Developed novel research methodologies for improved data analysis and interpretation.
- Identified opportunities for innovation by staying abreast of emerging trends in the scientific community.
- Completed testing projects by deadline and under budget for company-wide initiatives.
- Maintained a safe working environment by enforcing strict adherence to laboratory safety guidelines.
- Enhanced research efficiency by optimizing experimental designs and protocols.
Manager
Biophore India Pharmaceuticals Pvt Ltd
08.2019 - 09.2020
- Handled 8 chemists.
- Route scouting for intermediates/APIs' and developed commercially viable processes.
- Process optimization and trouble shooting of adjusting proejcts.
- Demo given to the production team and monitored the manufacturing batches to avoid the lower yield or higher impurities or failure of the batch.
- Prepared the cost sheet for on-going projects.
- Shared the progress of the on going projects in a weekly basis.
- Assigned the projects to team members based on reosureces availablity and monitored the on going projects on day to day basis.
- Accomplished API Projects at Biophore: Project-1: Nitazoxanide: Succesfully completed Nitazoxanide project from feasibility to Plant validation. Prepared 4 impurities.
- Project-2: Ramelteon: Succesfully completed Ramelteon project validation at R&D and plant validation competed. Prepared 5 impurities.
- Project-3: Erythromycin Lactobionate: Succesfully completed Erythromycin Lactobionate project validation at R&D.
- Project-4: Fenoprofen Calcium: Completed plant Validation. Prepared 3 impurities.
- Project-5: Primidone: Succesfuly completed validation in R and D. Prpeared 6 impurities.
- Project-6: Eluxadoline: Designed completely novel and shortest route and completed process optimization.
- Project-7: Benserazide: Project process optimized.
- Project-8: Ethiodized Oil: Process optimized.
Scientific Manager
GVK Biosciences
12.2013 - 11.2017
- Expert in synthesis of new complex molecules using modern technologies.
- Lead the 6-8 chemists team.
- Delivered hundreds of molecules in milli gram scale to kilogram scale.
- Custom synthesis and contract manufacturing process for the key intermediates that are part of NCE of Drug Discovery Program.
- Supported for FTE/FFS projects.
- Used to share the weekly update followed by telecon discussion items, research proposals and final summary reports.
- Updated project health on monthly basis for all the ongoing projects.
- Recieved gold award for good deliverables from GSK customer.
- Handled more than 3 customers at the same time.
Associate Research Scientist
Sai Life Sciences Ltd
04.2012 - 11.2013
- Worked as a scientist and prepared multiple flournated complex molecule for Scifluor customer.
- Handled 3 chemists along with my self.
- Used to share the weekly update followed by telecon discussion with corresponding client.
- Updated monthly project health for all the ongoing projects.
Post doctoral fellow
Purdue University
02.2011 - 03.2012
- Mentor: Professor Arun K. Ghosh
- Research Focus: Design and Synthesis of macrocyclic inhibitors of the Aspartic protease-Site Amyloid Precursor protein Ceaving Enzyme (BACE-1).
Post Doctoral Fellow
Purdue University
02.2011 - 03.2012
- Research Focus: Design and Synthesis of macrocyclic inhibitors of the Asparitic protease -Site Amyloid Precursor protein Ceaving Enzyme (BACE-1).
Education
Ph.D. - Organic Synthesis
Indian Institute of Chemical Technology
Hyderabad, India01.2011
M.Sc - Organic Chemistry
Andhra University, Government Arts & Science College
Rajahmundry, A.P, India01.2004
B.Sc - Chemistry, Mathematics, Physics
Andhra University, DNR College
Bhimavaram, West Godavari, A.P, India01.2002
Skills
Laboratory management
Scientific writing
Innovative thinking
Experimental design
Cross-functional teamwork
Expertise in research
Research and experiments
Project management
Safety processes and procedures
Planning and scheduling
Teamwork
Problem-solving
Time management
Problem-solving abilities
Multitasking Abilities
Excellent communication
Self motivation
Decision-making
Adaptability and flexibility
Self-driven and motivated
Training and mentoring
Timeline
Senior Principal Scientist
Piramal Pharma Limited
09.2020 - Current
Manager
Biophore India Pharmaceuticals Pvt Ltd
08.2019 - 09.2020
Scientific Manager
GVK Biosciences
12.2013 - 11.2017
Associate Research Scientist
Sai Life Sciences Ltd
04.2012 - 11.2013
Post doctoral fellow
Purdue University
02.2011 - 03.2012
Post Doctoral Fellow
Purdue University
02.2011 - 03.2012
M.Sc - Organic Chemistry
Andhra University, Government Arts & Science College
B.Sc - Chemistry, Mathematics, Physics
Andhra University, DNR College
Ph.D. - Organic Synthesis
Indian Institute of Chemical Technology
Post Doctoral Experience
Post doctoral fellow, Purdue University, West Lafayette, Indiana, USA, 2011-02-01, 2012-03-31, Professor Arun K. Ghosh, Design and Synthesis of macrocyclic inhibitors of the Asparitic protease -Site Amyloid Precursor protein Cleaving Enzyme (BACE-1).
Awards Fellowships
- Junior Research Fellowship (JRF), CSIR, New Delhi, India, 2006-01-01, 2008-01-01
- Senior Research Fellowship (SRF), CSIR, New Delhi, India, 2008-01-01, 2011-01-01
- Post Doctoral Fellowship, Purdue University, USA, 2011-02-01, 2012-03-31
Scientific Responsibilities
- Design and development of new synthetic methods for APIs & their key intermediates.
- Optimization of Process: In terms of operation, time-cycle, achieving targeted quality.
- Improving yields, reducing the cost and maximize throughput.
- Scale-up activities: Demonstration of lab process in pilot plant and production.
- Troubleshooting: During development of projects at both R&D and scale-up execution.
- Taking necessary corrective action followed by suggesting preventive action to the team.
- Building technical skills in team members by guiding & encouraging them.
- Providing scientific/technical reports to both coordinating departments and Plant for smooth execution of projects.
- Handling of Non-conformances like OOS/OOT and Customer Complaints in a logical manner and providing Technical Support by Scientific Approach with Experimental Evidence.
- Ensured 'The Value Addition' to the projects by scientific and technical improvements.
- Providing technical support to Plant to obtain regulatory approvals for executed projects.
- Focus on improving the cost of existing APIs and playing a key role in the selection of alternate Vendor Development (AVD) by providing experimental support.
Personal Information
- Date of Birth: 06/05/1982
- Nationality: Indian
- Marital Status: Married
Publications
- Palakodety Radha Krishna, T. Jagannadha Rao, First stereoselective total synthesis of Decarestrictine O via RCM. Protocol., Tetrahedron Lett., 2010, 51, 7473-7476
- Palakodety Radha Krishna, T. Jagannadha Rao, Total synthesis of Decarestrictine I and Botryolide B via RCM protocol., Org. Biomol. Chem., 2010, 8, 3130-3132
- Arun K. Ghosh, Jagannadharao Tirlangi, Andrew D. Mesecar, Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors, Biochemistry, 2019, 44, 4424-4435
- Arun K. Ghosh, Jagannadharao Tirlangi, Andrew D. Mesecar, A structure-based discovery platform for BACE2 and the development of selective BACE inhibitors, ACS Chemical Neuroscience, 2021, 12, 4, 581–588
Training
- H. C. Brown Symposium, 2011-04-30, West Lafayette, Indiana, USA
- INDO-US Conference on New Bioactive molecules in Pharmaceutical Research Contribution of Natural Products, INDO-US CCNP-2006, 2006-11-13, Hyderabad, Telangana, India
- International Conference on Advances in Organic Chemistry and Chemical Biology, AOCCB– 2010, 2010-03-11, Hyderabad, Telangana, India
- International Conference on Organic Synthesis and Human Well Being: Emerging Opportunities and Challenges, OSH.MW–2010, 2010-08-01, Hyderabad, Telangana, India
V. AWARDS/FELLOWSHIPS
Awarded as junior Research Fellowship (JRF) from CSIR, New Delhi, India (2006-2008), Awarded as Senior Research Fellowship (SRF) from CSIR, New Delhi, India (2008-2011)., Awarded as Post Doctoral Fellowship from Purdue university, USA (Feb 2011-March. 2012).
VI. LIST OF PUBLICATIONS
- Palakodety Radha Krishna and T. Jagannadaha Rao, “first streoselective total synthesis of Decarestrictine O via RCM. Protocol.” Tetrahedron Lett. 2010, 51, 7473-7476.
- Palakodety Radha Krishna and T. Jagannadaha Rao, “Total synthesis of Decarestrictine I and Botryolide B via RCM protocol.” Org. Biomol. Chem. 2010, 8, 3130-3132.
- Arun K. Ghosh, Jagannadharao Tirlangi and Andrew D. Mesecar, “Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors” Biochemistry, 2019, 44, 4424-4435.
- Arun K. Ghosh, Jagannadharao Tirlangi and Andrew D. Mesecar, A structure-based discovery platform for BACE2 and the development of selective BACE inhibitors, ACS Chemical Neuroscienc, 2021, 12, 4, 581–588.
- Participated in “H. C. Brown Symposium” April 30, 2011 conducted at Purdue University, Indiana, USA.
- “INDO-US Conference on New Bioactive molecules in Pharmaceutical Research Contribution of Natural Products, INDO-US CCNP-2006”, November 13-14, at Indian Institute of Chemical Technology, Hyderabad, India.
- “International Conference on Advances in Organic Chemistry and Chemical Biology, AOCCB–2010” March11-12, 2010, at Indian Institute of Chemical Technology, Hyderabad, India.
- Presented a poster entitled “Stereo selective total synthesis of 10 membered lactones via RCM” in “International Conference on Organic Synthesis and Human Well Being: Emerging Opportunities and Challenges, OSH.MW–2010” August 1-4, 2010, at Indian Institute of Chemical Technology, Hyderabad, India.
VIII. SCIENTIFIC RESPONSIBILITIES
- Design and development of new synthetic methods for APIs & their key intermediates.
- Optimization of Process: In terms of operation, time-cycle, achieving targeted quality.
- Improving yields, reducing the cost and maximize throughput.
- Scale-up activities: Demonstration of lab process in pilot plant and production.
- Trouble shooting: During development of projects at both R&D and scale-up execution.
- Taking necessary corrective action followed by suggesting preventive action to the team.
- Building technical skills in team members by guiding & encouraging them.
- Providing scientific/technical reports to both coordinating departments and Plant for smooth execution of projects.
- Handling of Non-conformances like OOS/OOT and Customer Complaints in a logical manner and providing Technical Support by Scientific Approach with Experimental Evidence.
- Ensured “The Value Addition” to the projects by scientific and technical improvements.
- Providing technical support to Plant to obtain regulatory approvals for executed projects.
- Focus on improving the cost of existing APIs and playing a key role in the selection of alternate Vendor Development (AVD) by providing experimental support.