GANESH SURAJ BOSE

"Submitted Ph.D. in Biotechnology entitles To understand the regulation and functions of AP-1 during adipocyte differentiation, I specialize in the handling of stem cells and cancer cells such as breast, colon and liver. My primary focus involves the differentiation of human mesenchymal stem cells into adipocytes, backed by proficiency in a range of advanced laboratory methodologies such as real-time PCR, immunostaining, Western blot, Chromatin immunoprecipitation (ChIP), RNA sequencing data handling, and docking. I have a track record of successful contributions to research projects, along with experience in leading research teams and managing complex projects. Actively seeking opportunities to apply my skills, develop new ones, and make a meaningful impact. Additionally, I study the anticancer and anti-inflammatory effects of Inonotus exudates on cancer cells. These investigations further expand my research scope, encompassing both adipogenesis and anticancer properties, and underline my commitment to exploring diverse avenues in biotechnology and cancer biology. Throughout my academic and professional journey, I have effectively led research teams and spearheaded complex projects, leading to significant contributions in various research domains. I am confident that my background in biology research, coupled with my leadership experience and passion for innovation, make me a strong candidate for the position.

· Qualified CSIR-NET JRF 2018

· Qualified Maharashtra State Eligibility Test for Assistant professor 2018

· Qualified GATE (Graduate Aptitude Test in Engineering) 2016

1. Bose, G. S., Kalakoti, G., Kulkarni, A. P., & Mittal, S. (2024). AP‐1/C‐FOS and AP‐1/FRA2 differentially regulate early and late adipogenic differentiation of mesenchymal stem cells. Journal of Cellular Biochemistry. IF: 4.0

2. Kalamkar, S. D., Bose, G. S., Ghaskadbi, S., & Mittal, S. (2023). Andrographolide and pterostilbene inhibit adipocyte differentiation by downregulating PPARγ through different regulators. Natural Product Research, 37(18), 3145-3151.IF: 2.861

3. Perween, N., Pekhale, K., Haval, G., Sirkar, G., Bose, G. S., Mittal, S. P., ... & Ghaskadbi, S. S. (2024). Identification and characterization of multidomain monothiol glutaredoxin 3 from diploblastic Hydra. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 110986 IF: 2.2

4. Perween, N., Pekhale, K., Haval, G., Bose, G. S.,Mittal, S. P., Ghaskadbi, S., & Ghaskadbi, S. S. (2023). Glutaredoxin 1 from evolutionary ancient Hydra: characteristics of the enzyme and its possible functions in cell. Biochemistry (Moscow), 88(5), 667-678.IF: 2.824

5. Ganesh Suraj Bose, Shruti Jindal, Kiran Gautam Landage, Aarzoo Jindal, Monali Prakash Mahale, Abhijeet P. Kulkarni, Smriti P. Mittal* (2023). SMAR1 and p53 regulated lncRNA RP11-431M3.1 enhances HIF1A translation via miR-138 during oxidative stress in colorectal cancer cells. Under Review in The FEBS Journal.

6. Kawashte Ganesh#; Bose Ganesh#; Sadawarte Sharwari; Kulkarni Abhijeet; Mittal Smriti *, Mahesh Borde* (2023). Transcriptomics analysis of cytotoxicity effect by Innonotus rickii (Pat.) Reid culture exudate in breast and colon cancer cells. Under Review in Gene Reports (# equal first Author).

7. Bose G S, Raje S, Kulkarni AP, Mittal S, “AP-1 regulates insulin resistance in adipocytes through non-coding RNAs: miR-421, miR-324 and UICLM.” Submitted to Biochemical and Biophysical Research Communications

8. Deepti U. Kirtani, Ganesh S. Bose, Monali P. Mahale, Smriti Mittal* and Anupa A. Kumbhar* (2023). Photo-induced Release of Fe(III), Cu(II) and Pt(II) Ions: Synthesis, Characterization, Cellular Uptake Studies, Antiproliferative and Antimetastatic activity. Submitted to Inorganic Chemistry - ACS Publications.

1. Ganesh Suraj Bose, Smriti Mittal*. “LncRNA RP11-431M3.1 regulates HIF-1A gene expression through miR-138 in colon cancer cells” poster presented in 11th RNA Group Meeting organized by DBT-National Centre for Cell Sciences, Pune, India on 01st to 3rd December 2022.

2. Ganesh Suraj Bose, Abhijeet Kulkarni and Smriti Mittal*. “To understand the function of transcription factor, AP-1 during adipogenesis” poster presented in Functional nucleic acids: Recent landscapes and therapeutic applications organized by INDIA-EMBO Lecture Courses, Regional Centre for Biotechnology, Faridabad, India on 16th -19th August 2022.

• Test the COVID samples as volunteer at CTC, SPPU