Athletics
K. THALA
Nanomaterials Researcher
Bengaluru
Summary
Seeking a Research Assistant position in applied nano biotechnology, I'm driven by a strong interest in addressing global health issues. With a background in nanomaterials, biochemistry, and microbiology, along with practical experience in advanced drug delivery systems, I bring detail-oriented skills and strong communication. I am proactive in identifying and solving problems, with a focus on process optimization and team support. I aim to contribute to research that influences therapeutic methods and addresses critical healthcare challenges.
Overview
7
7
years of professional experience
4
4
years of post-secondary education
5
5
Languages
Work History
Master's Final Dissertation Intern
Centre for Research in Pure Applied Sciences
Bengaluru
01.2024 - 01.2025
- Identified research gap in tackling the root of cancer- cancer stem cell with CD133 and its affinitive peptide using Silica NPs .
- Optimized the rate of Drug release from Si NPs with a core-shell strategy without using additional polymers.
- Supported team members in their experiments, also involved in lab maintenance, Quotation request and PO generation.
- Gained valuable experience working within a nanomaterials lab, applying literature reviews and paper communication directly into practice .
- Contributed to a positive team environment by collaborating with fellow interns in group meetings and journal club.
- Supervisor: Dr. Anil Chandra
- Graded: 10 GPA
Master's First Thesis Project
Manipal Institute of Regenerative Medicine
Bengaluru
01.2023 - 07.2023
- "Reusable and Non-invasive TiO2-based PDT patch generating synergistic ROS-induced RNS approach in antibacterial, anti-biofilm wound healing."
- Executed stated experiments for Inorganic NP based Thin films and NP aggregation avoidance strategies.
- Worked hands on with drug resistant bacteria & biofilms.
- Introduced to PDT and interesting ways to explore its effects (dye degradation, contact angle, AFM, ZOI test, ROS, RNS assays, Bio compatibility assays)
- Excellent communication skills, both verbal and written.
- Worked effectively in fast-paced environments.
- Supervisor: Dr. LN Ramana
- Graded: 9.31 GPA
Bachelor's Thesis Project
MS Ramaiah College of Arts Science & Commerce
Bengaluru
01.2021 - 01.2022
- "Bioinformatics tools used to analyze CCD and ALDH in the biosynthesis of Crocin seen in Crocus sativus."
- Visualized the concept to analyze key enzymes at the root of crossing, but executed it as a team.
- Introduced to GenBank, NCBI-Blast, MEGA, JALVIEW for phylogenetic tree of the enzymes.
- Supervisor: Dr Ramakrishna T.N
- Graded: 9.23 GPA
Thesis Project
Ramaiah Metropolis Lab
Bengaluru
01.2018 - 01.2019
- "Antibacterial effect of essential oils on E. Coli."
- High school final year Investigatory project inclined in Microbiology.
- Visualized the need to compare Antimicrobial effect of different essential oils, and executed own set of experiments in an external lab.
- Supervisor: Dr. Akshatha B
- Foundation, for my growing communication skills, both verbal and written.
Education
Master of Science - STEM CELL TECHNOLOGY AND REGENERATIVE BIOLOGY
Manipal Institute of Regenerative Medicine(MIRM), MAHE
Bengaluru, IN 04.2022 - 01.2024
Bachelor of Science - MICROBIOLOGY, BIOCHEMISTRY, GENETICS
MS Ramaiah College of Arts Science & Commerce
Bengaluru, IN 04.2019 - 01.2022
Skills
- Synthesis & Characterization of Nanomaterials
- Polymers
- Mesoporous silica nanoparticles sol-gel synthesis
- TiO2-Polymer Thin film preparation
- Peptide bioconjugation strategies
- Anti-cancer drug loading
- Surface modification
- Drug Release kinetics
- Light microscopy
- Fluorescent microscopy
- Zeta Potential
FE-SEM, TEM
UV-Vis, FL spectrophotometry
- AFM analysis
- TLC
- BET analysis
- Tissue engineering Techniques
- Mammalian Cell Culture Techniques (MSC, iPSC HeLA, Panc-1, HEK)
- Polymer Solvent casting (PVAC, PLA, PCL, PVA, Sodium Alginate, Chitosan, Na-CMC)
- Hydrogels preparation
- Scratch assay
- Electrospinning
Manual &Spin coating
- Scaffolding
- 3D bioprinting
- Mice Handling (Organ harvest, tissue processing, sectioning & staining)
- Microbial culture techniques (both bacterial, fungal)
- Plating techniques
- Bacterial enumeration
- Biofilm culturing
- Gram staining
- Oxidative stress assays
- Immunofluorescence assay
- Dye degradation studies
- Biocompatibility assays
- Research paper writing
- Microsoft office, ZOTERO
- Data collection
- Research design
- Research methods
- Literature reviews
- Research ethics
- Attention to detail
- Experimental design
- Project planning
- Running experiments independently
Publications
- K. Thala, A. Machina, S.Parveen, L. N. Ramana* (2024). "Reusable and non-invasive TiO2-based photodynamic transdermal patch (RPT) for treating MDR-negative bacteria strain and promote wound healing through a synergistic approach of ROS-induced RNS." Colloids and Surfaces B: Biointerfaces (Accepted on 5th October 2024, https://doi.org/10.1016/j.colsurfb.2024.114301).
- Designed & tested TiO2-polymer thin films for Antibacterial Photodynamic Therapy
- Evaluated Physicochemical, Biological, antibacterial & biofilm inhibition properties.
- Under Revision:
K. Thala, A. Machina, S. Ravishankar, A. Chandra* (2024). "Advances in Fluorescence-Based Point-of-Care Testing for Cardiac Biomarkers." Biosensors & Bioelectronics.
- Review on fluorescent nanomaterials for rapid biomarker detection with improved sensitivity.
Trained in workshops & Conferences
- Poster presentatioin- Bi-modal MSNPs for controlled drug release for cancer treatment, International Conference on Advances and Challenges in Medical Technology Translation, 12/2024
- Organized & volunteered in- 3-D Bioprinting Technology & Applications workshop, CRPAS, Bangalore, India, 11/2024
- Advanced tissue engineering techniques, MIRM, India, 01/2024
- Molecular Biology & Biochemistry Techniques, IISc, Bangalore, India, 05/2022
- Good manufacturing Practices in Pharmaceutics, MSRCASC, India, 06/2021
- Hands-on Training in Nanobiotechnology, MSRCASC, India, 03/2020
- Phenotypic heterogeneity in cancer, IISc, Bangalore, 01/2020
Interests
Comics
Amateur Guitarist (electric, acoustic)
REFERENCE
Dr. Anil Chandra (ASST. Prof , Central University of Kashmir, India)
Anilchandra87@gmail.com , Mobile: +91 9015279356 (AVAILABLE UPON REQUEST)
Timeline
Master's Final Dissertation Intern
Centre for Research in Pure Applied Sciences
01.2024 - 01.2025
Master's First Thesis Project
Manipal Institute of Regenerative Medicine
01.2023 - 07.2023
Master of Science - STEM CELL TECHNOLOGY AND REGENERATIVE BIOLOGY
Manipal Institute of Regenerative Medicine(MIRM), MAHE
04.2022 - 01.2024
Bachelor's Thesis Project
MS Ramaiah College of Arts Science & Commerce
01.2021 - 01.2022
Bachelor of Science - MICROBIOLOGY, BIOCHEMISTRY, GENETICS
MS Ramaiah College of Arts Science & Commerce
04.2019 - 01.2022
Thesis Project
Ramaiah Metropolis Lab
01.2018 - 01.2019
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