Kameshwar Rao R. AYASOLLA
Hyderabad; Telangana
Summary
Accomplished researcher with a PhD in Neuroscience specializing in molecular biology, biochemistry, and neonatology. Track record of driving high-impact publications and successful training programs in neonatal care, supporting record admissions and fellowships at Northwell Health. Skilled in developing innovative in vitro assays, conducting advanced animal experiments, and mentoring the next generation of scientists. Passionate about exploring the role of SNPs, nutritional genomics, epigenetic mechanisms, and cholinergic control in immune responses for impactful diagnostics and treatments. Committed to collaborative research and advancing medical science for improved patient outcomes.
Overview
28
28
years of professional experience
1
1
Certification
Work History
Research Scientist Instructor, Neurology
Henry Ford Health
Detroit
11.2020 - 09.2023
- Conducted research on the biology of EAE (MS mouse model) and related metabolomics in MS neuropathy
- Developed and implemented research protocols to identify a role of novel endogenous metabolites with specific anti-inflammatory, redox potential.
- Conducted laboratory experiments to evaluate the efficacy of various compounds in a range of applications.
- Write and submit grants to the Department of Defense. Did help PI file in grant proposals, as well as generated a lot of useful metabolite data.
Research Scientist, Nephrology/Neonatology
North-Well Health System Feinstein Institute for Medical Research (FIMR)
Manhasset
02.2011 - 09.2020
- Conducted research on APOL1-related nephrology issues and congenital diaphragmatic hernia in neonates through high-impact studies.
Aided PIs and Neonatologists in comprehending complex molecular aspects within the fields of Biochemistry and Molecular Biology, meeting performance benchmarks for standardization purposes.
High Impact publications attracting more quality candidates for NICU program at North well Health (2 units put together did help 140 admissions at any given time) and intake of almost 16-18 NICU fellows (~3 batches of 1, 2 and 3rdyear)
Help guide NICU and Neonatology attendees to complete and graduate their program with almost 100% success, with respect to training and compliance within Institute standards. Worked with a team of 20-40 employees to manage the various projects, in nephrology and in neonatology, overseeing funds valued << $4-5 million Family Foundation / Institute Research funds/ collaborative grants as well NIH grants (Nephrology) (Period of 9 years).
• Did help publish 15-20 odd publications from the work performed in Nephrology, Neonatology and in Neuroscience and did help submission of > 60-70 abstracts (all combined together) for various local, State level, national and international exhibits and conferences (ISN/ASN, PAS, International society on Sepsis etc.).
Cholinergic control of the immune response has been demonstrated through in vitro and ex vivo experimentation. It has a lot of commercial potential in future diagnostics and treatment.
• Help understand Epigenetic mechanisms in pulmonary functions, podocyte related pathology in HIV and in diabetes and did help establish pulmonary issues in Congenital diaphragmatic hernia (CDH)
Instructor/Staff Scientist
University of Algarve
Faro
06.2010 - 07.2011
- Contributed to systems biology research on Huntington’s Disease
Research Staff Instructor
Bar-Illan University/Tel-Hashomer Hospital
Ramat Gan
06.2008 - 01.2010
- Worked on peptidomimetics for neuroinflammatory research, resulting in a provisional patent
Post Doctoral Fellow (PDF)
Medical University of South Carolina (MUSC)
Charleston
02.1996 - 01.2007
- Developed and conducted training sessions for Fellows on a variety of topics. Including Cancer Biology, Neuroinflammatory conditions of Alzheimer's, Preeclampsia, Term Birth Issues, etc.
- Provided mentorship to new Fellows, helping them transition into their roles.
- Assisted with the development of performance metrics for Fellow evaluation.
Visiting Scientist
Weizmann Institute of Science
Rehovot
02.1996 - 02.1998
- Collaborated with Christiane from University of Oldenburg, Germany to investigate the role of p53/p21/p27 CIP KIP pathways in neuronal differentiation of OLN cells to mature oligodendrocytes (the myelinating cells in CNS).
- Gained valuable mentorship from Prof David Givol and previously retired Ephraim Yavin.
Education
Certificate Course - Health Care Management
Indian School of Business
Hyderabad, India09.2024
Ph.D. - Neuroscience
Tamil Nadu Dr. MGR Medical University
Chennai, IndiaM.S. - Life Sciences
University of Hyderabad
IndiaB.S. (Hons) - Zoology
Osmania University
Hyderabad, IndiaSkills
- Teaching Experience
- Mentoring
- Coaching
- Training
- Technical Proficiency
- Microsoft Office Suite
- GraphPad
- Statistical Analyses
Accomplishments
· Junior Research Fellowship, Council of Scientific & Industrial Research, India
· Senior Research Fellowship, Council of Scientific & Industrial Research, India
· International Society for Neurochemistry Travel Award
· Investigator Award XV World Congress of the International Society for the study of Hypertension in Pregnancy. Lisbon, Portugal (July 2006).
· US provisional Patent Filed in Year 2015, Peptidomimetics use of cyclic peptide nanotubes for treatment of MS (Shai Rahimipour, PI, Bar-Illan University, RamatGan, ISRAEL)
Advisoryactivities
Advisory activities
2003-2018 Reviewer, International Alzheimer’s Association Grant Award.
2013- Present Editorial Board, Austin Journal of Computational Biology and Bioinformatics. http://austinpublishinggroup.com.
2018- Present Editorial Board Member Addiction & Criminology. http://www.alliedacademies.org/addiction-criminology/editors.php
2013- Present Editorial Board Austin Journal of Nephrology.
2012 –2018 Adhoc reviewer Canadian Journal of Physiology and Pharmacology
2008- Present; Adhoc Reviewer: Apoptosis; Plos one; Journal of Biological Chemistry; BMC Neuroscience; FASEB.t
publications (past 6 years)
1) An early glycolysis burst in microglia regulates mitochondrial dysfunction in oligodendrocytes under neuroinflammation......Suhail H, …….Ayasolla K, …...iScience. 2023 Sep 15;26(10):107921. PMID: 37841597
2) Pro-resolution lipid mediator maresin-1 .Insha , … Kamesh Ayasolla,et al ..BIORXIV doi:
3) Zaghloul N, & Ayasolla KR et al .. Galantamine ameliorates hyperoxia-induced brain injury in neonatal mice. Front Neurosci. 2023 Jun 22;17:890015; 2023.890015. PMID: 37424990;
4) Katti K, Ayasolla KR et al . Lipid peroxidation products as predictors of oxidant-mediated disease in preterm infants. Matern Fetal Neonatal Med. 2021 Jan 4:1-6. PMID: 33397176
5) Rajgarhia A, Ayasolla KR.et al .Front Cardiovasc Med. 2021 May 31;8:669975. PMID: 34136546 Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress.]
6) Lopez Da Re JM , Kamesh A et al .. EC-SOD can prevent the chronic stages of pulmonary hypertension induced by hypoxia. Integrative Molecular Medicine. 2020.Volume 6: 1-9. https://www.oatext.com/pdf/IMM-6-389.pdf (Not available in PubMed).
7) Jha,A, Kamesh Ayasolla, et al .MiR193a Modulation and Podocyte Phenotype. Cells. 2020 Apr; 9(4): 1004.
8) Jha,A, Kamesh Ayasolla, et al .. Alterations in Plasma Membrane Ion Channel Structures Stimulate NLRP3 Inflammasomes Activation in APOL1 Risk Milieu FEBS J. 2020 May; 287(10): 2000–2022. febs.15133 PMCID
9) Shahana Perveen, Kamesh Ayasolla, et al . MIF Inhibition Enhances Pulmonary Angiogenesis and Lung Development in Congenital diaphragmatic Hernia . Pediatr Res 2019 Apr;85(5):711-718 PMID: 30759452.
10) Kumar,V Kamesh Ayasolla, et al . Disruption of APOL1-miR193a Axis Induces Disorganization of Podocyte Actin Cytoskeleton. Sci Rep. 2019; 9: 3582.
11) Ayasolla K, et al .Disrupted apolipoprotein L1-miR193a axis dedifferentiates podocytes through autophagy blockade in an APOL1 risk milieu. Am J Physiol Cell Physiol. 2019 Aug 1;317(2):C209-C225. PMID: 31116585
12) Kumar V, … Ayasolla K, et al .Alterations in Plasma Membrane Ion Channel Structures Stimulate NLRP3 Inflammasomes Activation in APOL1 Risk Milieu. FEBS J. 2020 May; 287(10): 2000–2022. Published online 2019 Dec 2. doi: 10.1111/febs.15133. PMCID: PMC7298666.
13) Kumar V, …. Ayasolla K, et al .. Role of APOL1 in Human Parietal Epithelial Cell Transition. Am J Pathol. 2018 Sep 7. PMID: 30201495.
Certification
- Leadership course from Harvard EX. 2020
- Certificate course/ Diploma in Nutritional Genomics for Professionals and Nutritionists. Institute of NutriGenomics, Spain.
References
References available upon request.
Timeline
Research Scientist Instructor, Neurology
Henry Ford Health
11.2020 - 09.2023
Research Scientist, Nephrology/Neonatology
North-Well Health System Feinstein Institute for Medical Research (FIMR)
02.2011 - 09.2020
Instructor/Staff Scientist
University of Algarve
06.2010 - 07.2011
Research Staff Instructor
Bar-Illan University/Tel-Hashomer Hospital
06.2008 - 01.2010
Post Doctoral Fellow (PDF)
Medical University of South Carolina (MUSC)
02.1996 - 01.2007
Visiting Scientist
Weizmann Institute of Science
02.1996 - 02.1998
Certificate Course - Health Care Management
Indian School of Business
Ph.D. - Neuroscience
Tamil Nadu Dr. MGR Medical University
M.S. - Life Sciences
University of Hyderabad
B.S. (Hons) - Zoology
Osmania University
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