Karthikeyan Chinnakalai

Experienced process scientist and engineering professional with a track record of optimizing process and operational workflows to drive efficiency improvements. Proficient in process design, process engineering, continuous flow chemistry, and data analysis, with a strong focus on fostering team collaboration and achieving organizational goals. Recognized for reliability and adaptability in dynamic environments.

• Applications of Flow chemistry in API Synthesis, Prof. Paul Watts, Glostem Private Limited, Mumbai, India, 09/01/23
• Manage Project Professionally, PMCC, Project Management Institute, Bangalore, Karnataka, India, 02/01/17, PMCC109

• Route Design & Scouting for Active Pharmaceutical Ingredient's (API)
• Flow chemistry (Improve Safety, reduce cycle time, High-throughput, Increase quality & Yield)
• Photo flow chemistry, Design of Experiments (DoE) - Screening & Optimization for flow chemistry

• Synthesis of New Chemical Entities (NCE), Active Pharmaceutical Ingredients (API's) and their intermediates. Purification of the same by column chromatography, Prep-HPLC techniques or crystallization techniques
• Worked with parallel synthesizer, endeavor and miniclave for performing the multiple experiments
• Experienced in Flow chemistry & hands on experience in Vapourtec R series Flow Reactors, multiple pumps for flow experiment
• Hands on experience in PAT tools (FBRM, Blaze metrics) for crystallization studies
• Experienced on DoE (Design of Experiments) with Design Expert and MODDE software
• Hands on experience in safe handling of moisture sensitive and pyrophoric reagents and highly potential compounds (HP-API)
• Super user on Sci-Finder and Reaxy's databases for literature search

• Vast knowledge on Risk assessment & Process Flow diagram to scale up the process in pilot plant
• Successfully demonstrated the critical process from gram scale to kilogram scale in pilot plant
• Experienced in high potent laboratory to handle the High Potent- API (Bang-5, TH-5)
• Successfully executed many cGMP process of penultimate & API stages in pilot plant
• Scale-up of flow chemistry from gram to kilogram scale in Large Scale Laboratory

• Flow Chemistry Society annual conference - 2023, Mumbai, India
• Understanding Polymorphism and Crystallization Issues in the Pharmaceutical Industry, Mayfield, UK, United Kingdom
• Chemical Development & Scale up, Bangalore, Karnataka, India
• Recent Advances in Organic Chemistry, Bangalore, Karnataka, India
• Micro Scale Experiments in Organic Chemistry, Nagercoil, Tamil Nadu, 629002, India

• BRAVO Award for Effective Process Development & Optimization for Crystallization and Form, Biocon Bristol-Myers Squibb R&D Center (BBRC), 04/01/23
• A Star Award for route scouting and total synthesis of unstable TosMIC on a scale, Biocon Bristol-Myers Squibb R&D Center (BBRC), 11/01/16
• Galaxy Award for on-time delivery of HIV Inhibitor to support the IND-Tox studies, Biocon Bristol-Myers Squibb R&D Center (BBRC), 04/01/15
• Best Science Project Award, AstraZeneca India Pvt. Ltd., 12/01/12
• Best Safety, Health and Environmental (SHE) lab award, AstraZeneca India Pvt. Ltd., 06/01/12
• Best and Highest number of Experiment Award, AstraZeneca India Pvt. Ltd., 12/01/11
• Tamil Nadu State Council of Scientific Award for my master's degree research project, Tamil Nadu State Government, 12/01/10

• Development of a Scalable Synthesis of the Small Molecule TGFβR1 Inhibitor BMS-986260, Muthalagu Vetrichelvan, Souvik Rakshit, Sathishkumar Chandrasekaran, Karthikeyan Chinnakalai et.al, Organic Process Research & Development (ACS), 2020, 24, 7, 1310-1320
• Convenient N-acetylation of amines in N, N-dimethylacetamide with N, N-carbonyldiimidazole, Anil Chikkulapalli, Sanjeev Kumar Aavula, Rifahath Mona NP, Karthikeyan C, Vinodh Kumar CH, Manjunatha Sulur G, Shanmugam Sumathi, Tetrahedron Letters (Elsevier), 2015, 56, 3799-3803