Summary
Overview
Work History
Education
Skills
Affiliations
Academic Accolades
Academic Activities
Preferred Industry
Knowledge Purview
Publications
References
Certification
Languages
Timeline
Generic

KIRUBAKARAN SHANMUGAM

Nashik

Summary

I am a determined and well-rounded individual with over 23 years of experience in the biopharmaceutical industry. I have a strong background in biochemistry and genetics and am skilled in conducting laboratory and field experiments. I am proficient in advanced laboratory equipment use and techniques and have expertise in data analysis. I am a hardworking and driven professional with superior organizational and analytical skills, and I am dedicated to conceptualizing, designing, and implementing research projects. I am seeking a full-time position that offers professional challenges utilizing my interpersonal skills, excellent time management, and problem-solving skills.

Overview

21
21
years of professional experience
1
1
Certification

Work History

Senior Scientist, Head – Immunotherapy

Datar Cancer Genetics Ltd
06.2021 - Current
  • Research involving in vitro & in vivo bioassay development for cancer theranostics; guiding a team of researchers involved in diagnostic technologies and cancer therapy research
  • Cancer vaccine development – autologous & allogeneic; for both human and pets
  • Developed cancer vaccines for both humans and pets including TILs, DCs, Lysate vaccines, NK cells
  • Spearheaded vaccine manufacturing team engaged in immunogenicity, bioassay, and analysis activities
  • In-charge of GMP facility for vaccine production; assisted in developing acceptable work policies and procedures that meet industry regulatory standards
  • Developed and implemented strategies for the assessment of immunogenicity of therapeutic peptides, proteins, and concentrates
  • Designed and oversaw the development of cell-based bioassays for potency, stability, and characterization of therapeutic peptides, proteins, and concentrates
  • Ensured compliance with regulatory guidelines, industry standards, and internal quality management systems for all tests/assays developed from the department
  • Assisted in validation processes of new platforms and their documentation
  • Responsible for preparing project proposals, project planning and execution, technical reports, attending to technical queries, assessing patient information’s data from experiments, QMS
  • Collaborated with cross-functional teams to ensure that immunogenicity, bioassay, and GMP-related activities are aligned with project goals and timelines
  • Stayed current with scientific advancements and regulatory requirements in the field of cancer immunotherapy, immunogenicity, bioassays, and relevant analysis
  • Fostered a culture of innovation, scientific excellence, and continuous improvement within the team
  • Significant Highlights: Developed cancer vaccines from scratch to testing license
  • Set up GMP facility for vaccine development and supported associated ISO certifications
  • Participated in regulatory submissions and interactions with regulatory authorities regarding immunogenicity, bioassay, and GMP-related topics.

Senior Scientist, Project lead

Dept of Biotechnology, University of Madras
01.2019 - 06.2021
  • Research involving in vitro bioassay on neurodegenerative models
  • Conducting cell culture Lab for the research students
  • Supporting masters and doctorate students’ thesis work
  • Significant Highlight: Involved in setting up the cell culture and analytical labs in the Biotechnology department.

Assistant professor

Biotech Department, Wachemo University
11.2016 - 11.2018
  • Leading and guiding the teaching and research faculty in the departments of Biotechnology and Pharmacology
  • Delivered lectures on the theories of Biochemistry, Immunology, Pharmaceutical Biotechnology & Pharmacology
  • Conducting cell culture Lab for the research students
  • Significant Highlight: Involved in setting up the Cell culture and Pharmacology labs in the Biotechnology department.

Chief Scientific Officer

Areete Life Sciences Pvt Ltd.
- 10.2016
  • Research support for new herbal formulations
  • Studying the pharmacological activities using cell culture models
  • Exploring the medicinal chemistry of the main constituents using cell culture techniques, analytical methods such as chromatography, spectroscopy, etc
  • Studying pharmacokinetic properties & stability studies
  • Recruitment, training and leading the scientific team
  • Significant Highlight: Setting up and in-charge of laboratory.

Tutor & Demonstrator

University of Western Sydney
08.2008 - 04.2012
  • Teaching activities, Problem based learning, laboratory demonstration for medical and biological science students
  • Co-supervised Honours’ and Masters’ research projects.

Tutor & Demonstrator

James Cook University
05.2007 - 07.2008
  • Teaching activities, Problem based learning, laboratory demonstration for molecular sciences, pharmacy and biological sciences students.

Research Associate

Biotech Dept, Orchid Chemicals & Pharmaceuticals Ltd.
05.2005 - 06.2006
  • Research of metabolic engineering of Pencillium chrysogenum to produce Cephalosporin producing enzymes and bioconversion of Penicillin into Cephalosporin
  • Biotransformation of P.chrysogenum
  • Development of fermentation process for Penicillium (Recombinant) cells
  • Protein expression
  • Significant Highlight: Developing the process for scaling up of the fungus from shake flask titres to 50 l fermentors.

Research Associate

Bioinformatics Department, Fundastik Life Sciences
01.2005 - 05.2005
  • Algorithm Development for ‘Protein Active Site Prediction Tool’
  • Leading a team of Bioinformaticians
  • Involved in recruitment and training new recruits on the theories of Molecular Biology & Biotechnology
  • Significant Highlight: Instrumental in successful development of an algorithm for ‘Protein Active Site Prediction Tool’.

Lecturer

Biotech Department, Rajalakshmi Engineering College
06.2004 - 01.2005
  • Delivered lectures on the theories of Genetic Engineering & Animal Biotechnology
  • Conducted Molecular Biology Lab for the Biotechnology graduate (B.Tech.) students
  • Involved in setting up of all the labs in the Biotech Department & their maintenance
  • Significant Highlight: Produced 100% results in both the theory and Practical exams conducted by the University.

Executive Trainee

Wockhardt Biotech Park
06.2003 - 05.2004
  • Production of Hepatitis-B Vaccine concentrates & regarding documentation works (Installation & Operational Qualifications); the process included: Upstream Processing: Scale Up of H.polymorpha (Recombinant) Cells using Fermentors of Volumes in a Series of Shake Flask, 5 l, 50 l & 500 l & Expression of the Hepatitis-B Antigen Gene at the 500 l Fermentor Stage
  • Downstream Processing: Antigen Isolation & Purification.

Education

PhD - School of Pharmacy and molecular sciences

James Cook University
Townsville, Australia
01.2014

M.Tech. - Biotechnology

Centre for Biotechnology, Anna University
Chennai, Tamil Nadu
01.2001

B.Pharm. -

The Tamil Nadu Dr. M. G. R. Medical University
Chennai, Tamil Nadu
01.1998

Skills

  • Microsoft Word
  • Written Communication
  • Problem-Solving
  • Relationship Building
  • Analytical and Critical Thinking
  • Attention to Detail
  • Task Prioritization
  • Time Management

Affiliations

  • State Pharmacy Council of India (Lifetime Member)
  • Medscape Pharmacists

Academic Accolades

  • DBT Fellowship for M.Tech., at Centre for Biotechnology, Anna University, (Aug’99 – Jan’01).
  • 1st Class with Distinction in M.Tech. degree awarded by Anna University (2001).
  • 3rd rank in the nation-wide entrance CEEB (Combined Entrance Examination – Biotechnology) 1999 to get admission into M.Tech. (Biotechnology).
  • CSIRO-Preventative Health Fellowship for Ph.D. (Jan’08 to Dec’10).
  • JCU Doctoral Scholarship Extension (Jan’11 – Oct’11).
  • PhD thesis has received distinction reviews.

Academic Activities

Special training on Recombinant Human Insulin Manufacturing Project, Wockhardt-Merind Ltd., Mumbai, India (Dec’03)., 

Summer Trainee in Molecular Oncology Lab, Cancer Institute (W.I.A), Chennai (2000)., 

Internship in Quality Control Department of Fischer Inorganics and Aromatics Pvt. Ltd., Thiruvallur, TN (Dec’97)., 

Indian Immunological Society’s Annual National Conference at Chennai, India (Nov’05)., 

50th Indian Pharmaceutical Congress Golden Jubilee Commemorations and 17th Asian Congress of Pharmaceutical Sciences, Mumbai, India (Dec’98)., 

47th Indian Pharmaceutical Congress at Chennai, India, (Dec’95)., 

Presided Pharmaceutical sciences workshop, Tirumala College of Pharmacy, Nizamabad, India (Apr’15)., 

“Pharmaceutical Marketing and Management”, Periyar Institute of Pharmaceutical Sciences, Trichy, India (Jan’97).

Preferred Industry

BioPharma / Biotechnology / Education / Healthcare

Knowledge Purview

Genomic DNA Isolation, Isolation of Plasmid DNA, mRNA Isolation, AGE, Antigen Isolation, PCR, RT-PCR, ELISA, Fungal Transformation, Protein Isolation, Western Blotting, Human Cancer Cells, Patient derived tumor cells, murine microglial cells, murine macrophages, neuronal cell cultures, Tissue Explant Cultures, Primary Cell Culture, Yeast Cell Culture (Recombinant H.polymorpha), Fungal Cell Culture (P. chrysogenum Transformants), HPLC, RP-HPLC, Expanded Bed Chromatography, Hydrophobic Interaction Chromatography, GFC, IEC, TLC, GC, Paper Chromatography, TFF, CFF, Ultracentrifugation, LymphoPrep, ELISA, Immunodiffusion, Immunoblotting, Affinity Chromatography, Flow cytometry, Electrophoresis, Gel-Doc, ELISA Readers, PCR Machines, UV/ VIS Spectrophotometers, Calorimeters, Flame Photometers, Scintillation Counters, 5, 16, 50 & 500 litres Fermentors [BioEngineeringTM & Software- ParagonTM TNT], 1500 litres Fermentor [Alfa LavalTM-& Software Alfa LavalTM], HPLC [Shimadzu & Software-ClassVP], HPLC [Agilent & Software-Waters], Ion Exchange Chromatography [Amersham Biosciences- BioprocessTM systems & Software-UnicornTM], GFC [Amersham Biosciences- BioprocessTM Systems & Software-UnicornTM], FPLC [AKTA purifier & Software-UnicornTM], Dyno mill, Rotavapour Evaporators, Incubators, Centrifuges [Mettler Toledo], Ultracentrifuges [Beckman Coulter 85K & 70E], Ultra Filtration Assembly [Millipore ProfluxTM M12], GC-MS [Agilent (California, USA) 7890A gas chromatograph with 5975C inert XL EI/CI mass selective detector (MS) and CombiPral, a CTC-PAL autosampler], Python, SQL, MS-Excel, Graphpad Prism 9.3, Zotero, Endnote, HTS corrector, Sigmaplot 10.0, FASTA, BLAST, Bioedit, RASMOL, Workbench, Swiss PDB Viewer, ADOBE– Photoshop, Illustrator, Acrobat 3D, Designer, PageMaker, Dreamweaver, GIMP, Logo Design Studio, AnimFX, CorelDraw, Pixellab, Canva, Wix creator, MS-Office, MS-One Note, MS-Word, MS-PowerPoint

Publications

  • Kirubakaran S, Holmquist L, Steele M, Stuchbury G, Berbaum K, Schulz O, Benavente-García O, Castillo J, Burnell J, Garcia Rivas V, Dobson G, Münch G, Plant-derived Polyphenols Attenuate Lipopolysaccharide Induced Nitric Oxide and TNF Production in Murine Microglia and Macrophages. Mol Nutr Food Res. (2008).
  • Kirubakaran S, Maczurek A, Münch G, α-Lipoic Acid in the Treatment of Diabetic Polyneuropathy and Alzheimer’s Disease. Medical Progress. (2007).
  • Gunawardena D, Bennett L, Shanmugam K, King K, Williams R, Zabaras D, Head R, Ooi L, Gyengesi E, G. Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-γ activated murine macrophages. Food Chem. (2014).
  • Gunawardena D, Shanmugam K, Low M, Bennett L, Govindaraghavan S, Head R, Ooi L, Münch, Determination of anti-inflammatory activities of standardised preparations of plant- and mushroom-based foods. Eur J Nutr (2014).
  • Maczurek A, Kirubakaran S, Münch G, Inflammation and the Redox-Sensitive AGE-RAGE pathway as a Therapeutic Target in Alzheimer’s Disease. Ann NY Acad Sci. (2007).
  • Kirubakaran S, Maczurek A, Young S, Münch G. α-Lipoic Acid in the Treatment of Diabetic Polyneuropathy and Alzheimer's Disease. Intl J Biomed Pharma Sci. (2007).
  • Katrin Berbaum, Kirubakaran Shanmugam, Grant Stuchbury, Florian Wiede, Heiner Körner, Gerald Münch, Induction of Novel Cytokines and Chemokines by Advanced Glycation Endproducts Determined with a Cytometric Bead Array, Cytokine. (2008).
  • Dave Chandler, Ameha Woldu, Anton Rahmadi, Kirubakaran Shanmugam, Nicole Steiner, Elise Wright, Obdulio Benavente-García, Oliver Schulz, Julián Castillo, Gerald Münch, Effects of plant-derived polyphenols on TNF-α and nitric oxide production induced by advanced glycation endproducts, Mol Nutr Food Res. (2010).
  • Anjaneya S. Ravipati, Lin Zhang, Kirubakaran Shanmugam, Gerald Münch, Sundara Rao Koyyalamudi, Narasimha Reddy, John Bartlett, Ming Jie Wu, Anti-oxidant and anti-inflammatory activities, total phenolics and flavonoid content of selected 29 Chinese medicinal plant extracts, LWT- Food Science and Technology. (2011).
  • Lin Zhang, Anjaneya S. Ravipati, Sundar Rao Koyyalamudi, Sang Chul Jeong, Narasimha Reddy, Paul Smith, John Bartlett, Kirubakaran Shanmugam, Gerald Münch, Ming Jie Wu, Antioxidant and Anti-inflammatory Activities of Extracts of Selected Chinese medicinal plants and their relation with antioxidant content, BMC Complementary and Alternative Medicine (2012).
  • Matthew J. Sharman, Giuseppe Verdile, Shanmugam Kirubakaran, and Gerald Münch, “Inflammation in Alzheimer's Disease, and Prevention with Antioxidants and Phenolic Compounds - What Are the Most Promising Candidates?” Neurodegeneration and Alzheimer's disease, pp. 233–266, 2019.

References

  • Professor Gerald Muench, Chair of Pharmacology, University of Western Sydney, Sydney, Australia, g.muench@uws.edu.au, +61 298524600, +61 298524718
  • Professor S.Elumalai, Registrar, University of Madras, Chennai, Tamil Nadu, ananandal@gmail.com, +91 88254 71883
  • Dr.G.Karthikeyan, Associate Professor, Amity University, Delhi, India, karanarohan@gmail.com, gkarthikeyan@amityedu, +91 9840715071

Certification

Basics of SQL

Basics of Python

Radiation safety

Biosafety

Languages

Tamil
Bilingual or Proficient (C2)
English
Bilingual or Proficient (C2)
Hindi
Upper intermediate (B2)

Timeline

Senior Scientist, Head – Immunotherapy

Datar Cancer Genetics Ltd
06.2021 - Current

Senior Scientist, Project lead

Dept of Biotechnology, University of Madras
01.2019 - 06.2021

Assistant professor

Biotech Department, Wachemo University
11.2016 - 11.2018

Tutor & Demonstrator

University of Western Sydney
08.2008 - 04.2012

Tutor & Demonstrator

James Cook University
05.2007 - 07.2008

Research Associate

Biotech Dept, Orchid Chemicals & Pharmaceuticals Ltd.
05.2005 - 06.2006

Research Associate

Bioinformatics Department, Fundastik Life Sciences
01.2005 - 05.2005

Lecturer

Biotech Department, Rajalakshmi Engineering College
06.2004 - 01.2005

Executive Trainee

Wockhardt Biotech Park
06.2003 - 05.2004

Chief Scientific Officer

Areete Life Sciences Pvt Ltd.
- 10.2016

PhD - School of Pharmacy and molecular sciences

James Cook University

M.Tech. - Biotechnology

Centre for Biotechnology, Anna University

B.Pharm. -

The Tamil Nadu Dr. M. G. R. Medical University
KIRUBAKARAN SHANMUGAM