Krishnaveni Mohareer
Summary
Dedicated Postdoctoral Research Fellow with hands-on experience and record of accomplishment in molecular biology and infectious disease research. Self-motivated and hardworking professional with methodical and detail-oriented approach.
Overview
26
26
years of professional experience
Work History
Post Doctoral Fellow
University of Hyderabad
Hyderabad
01.2014 - Current
- Professional recognition, awards, fellowships received
- Recipient DST-WOS-A research grant for the proposal, “Identification of Quorum sensing system in Mycobacterium tuberculosis” effective from 10 August 2017 till February 9 2020
- Recipient of CSIR-SRA (Pool Scientist) on the topic, “Apoptosis in the pathobiology of tuberculosis” during 23
11.2015 - 08.2017
- Recipient of DST SERB Young Scientist research award, 2012 for “Identification and characterization of Quorum sensing regulators in Mycobacterium tuberculosis”
- Recipient of Dr DS Kothari PDF fellowship, 2010 in “Understanding the Molecular pathogenesis of Mycobacterium tuberculosis: The role of PE/PPE family proteins”
- Co-PI in DBT-RGYI project entitled, "Understanding the Transcriptional Regulation and Identification of global regulators of PE/PPE genes of Mycobacterium tuberculosis" (2010)
- Selected for an oral presentation at The 9th Asian-Pacific Conference on Transcription (ACT-IX), National Institutes of Health, Taiwan
- Delivered a talk on “Baculovirus P35 functionally interacts with host oxidative stress induced P53 like factor to inhibit its DNA binding and transcriptional activity”
- Qualified CSIR (Council of Scientific and Industrial Research) exam, Life Sciences
- Recipient of a 5-year fellowship from CSIR for pursuing a career in research
Post Doctoral Fellow
Institute of Life Sciences
Hyderabad
01.2008 - 07.2014
Project Associate
DNA Fingerprinting &Diagnostics
Hyderabad
01.2007 - 01.2008
Project Fellow
DNA Fingerprinting and Diagnostics
11.2005 - 01.2007
SRF at Centre for DNA Fingerprinting and Diagnostics
Hyderabad
11.2002 - 11.2005
University of Hyderabad
06.2001 - 06.2005
- In the top 20%
- Recipient of Scholarship from Department of Biotechnology, pursuing a Masters course in Biotechnology at the
DNA Fingerprinting and Diagnostics
Hyderabad
11.2000 - 11.2002
01.1998 - 01.2000
- Ranked All India 4th in Graduate Aptitude Test in Engineering with 99.71 percentile (2000).
Education
PhD -
Biochemistry Centre for DNA Fingerprinting and Diagnostics, University of Hyderabad
01.2007
MSc - Biotechnology
University of Hyderabad
01.2000
BSc - Zoology, Chemistry
Osmania University College for Women Genetics
01.1998
Skills
Name: M Krishnaveni
Mailing address
H No 8-1-284/OU/263 OU Colony,
Behind Kakatiya High School,
Shaikpet Hyderabad 500006
Telephone: 04023561660 (R) 04066794673 (O)
Mobile no: 9948886429
Technical Expertise
Molecular biology
- Handling of microorganisms including non-pathogenic (Escherichia coli, Mycobacterium smegmatis) and pathogenic (Mycobacterium tuberculosis)
- Manipulation of DNA, cloning, expression and purification of proteins using both E coli and Baculovirus systems
- PCR, RTPCR
- Radioactive labeling of nucleic acids
- Southern, Northern, Western and South Western blotting
- Screening of expression libraries by Immuno- and Southwestern screening
Biochemistry
- Spectrophotometry
- Enzyme kinetics
- Electrophoretic mobility Shift Assay (EMSA)
- Purification of proteins both recombinant and native proteins by affinity and conventional methods
- Gel Filtration
Cell culture
- Animal cell culture, and transfection of insect and mammalian cells
- Construction of Recombinant Baculovirus
- FACS
Computer skills
- Knowledge of working in OS including
- Windows NT, Windows XP, Mac OS 90, Mac OS
- X (Darwin)
- Microsoft Office suite: Word, Powerpoint and Excel
- DNA Star suite (includes Edit Seq, Geneman, Protean, MegAlign, Seqman and MapDraw)
- Image Processing: ImageQuant (Amersham Biosciences), QuantityOne (BioRad)
Timeline
11.2015 - 08.2017
Post Doctoral Fellow
University of Hyderabad
01.2014 - Current
Post Doctoral Fellow
Institute of Life Sciences
01.2008 - 07.2014
Project Associate
DNA Fingerprinting &Diagnostics
01.2007 - 01.2008
Project Fellow
DNA Fingerprinting and Diagnostics
11.2005 - 01.2007
SRF at Centre for DNA Fingerprinting and Diagnostics
11.2002 - 11.2005
University of Hyderabad
06.2001 - 06.2005
DNA Fingerprinting and Diagnostics
11.2000 - 11.2002
01.1998 - 01.2000
PhD -
Biochemistry Centre for DNA Fingerprinting and Diagnostics, University of Hyderabad
MSc - Biotechnology
University of Hyderabad
BSc - Zoology, Chemistry
Osmania University College for Women Genetics
Languages
Publications
1: Yandrapally S, Agarwal A, Chatterjee A, Sarkar S, Mohareer K, Banerjee S. Mycobacterium tuberculosis EspR modulates Th1-Th2 shift by transcriptionally regulating IL-4, steering increased mycobacterial persistence and HIV propagation during co-infection. Front Immunol. 2023 Oct 19; 14:1276817. doi: 10.3389/fimmu.2023.1276817.
2: Mohareer K, Banerjee S. Mycobacterial infection alters host mitochondrial activity. Int Rev Cell Mol Biol. 2023;377:87-119. doi: 10.1016/bs.ircmb.2023.01.007. Epub 2023 Mar 10.
3: Sarkar S, Balakrishnan K, Chintala K, Mohareer K, Luedde T, Vasudevan AAJ, Münk C, Banerjee S. Tough Way In, Tough Way Out: The Complex Interplay of Host and Viral Factors in Nucleocytoplasmic Trafficking during HIV-1 Infection. Viruses. 2022 Nov 12;14(11):2503. doi:10.3390/v14112503.
4: Balakrishnan K, Munusami P, Mohareer K, Priyakumar UD, Banerjee A, Luedde T, Mande SC, Münk C, Banerjee S. Staufen-2 functions as a cofactor for enhanced Rev-mediated nucleocytoplasmic trafficking of HIV-1 genomic RNA via the CRM1 pathway. FEBS J. 2022 Nov;289(21):6731-6751. doi: 10.1111/febs.16546.
5: Balakrishnan K, Jaguva Vasudevan AA, Mohareer K, Luedde T, Münk C, Banerjee S. Encapsidation of Staufen-2 Enhances Infectivity of HIV-1. Viruses. 2021 Dec 8;13(12):2459. doi: 10.3390/v13122459. PMID: 34960728; PMCID: PMC8703407.
6: Nehvi IB, Quadir N, Khubaib M, Sheikh JA, Shariq M, Mohareer K, Banerjee S, Rahman SA, Ehtesham NZ, Hasnain SE. ArgD of Mycobacterium tuberculosis is a functional N-acetylornithine aminotransferase with moonlighting function as an effective immune modulator. Int J Med Microbiol. 2022 Jan;312(1):151544. doi: 10.1016/j.ijmm.2021.151544. Epub 2021 Dec 7. PMID: 34922100.
7: Chintala K, Mohareer K, Banerjee S. Dodging the Host Interferon-Stimulated Gene Mediated Innate Immunity by HIV-1: A Brief Update on Intrinsic Mechanisms and Counter-Mechanisms. Front Immunol. 2021 Jul 29;12:716927. doi: 10.3389/fimmu.2021.716927.
8: Yandrapally S, Mohareer K, Arekuti G, Vadankula GR, Banerjee S. HIV co-receptor-tropism: cellular and molecular events behind the enigmatic co-receptor switching. Crit Rev Microbiol. 2021 Aug;47(4):499-516. doi:10.1080/1040841X.2021.1902941.
9: Mohareer K, Medikonda J, Vadankula GR, Banerjee S. Mycobacterial Control of Host Mitochondria: Bioenergetic and Metabolic Changes Shaping Cell Fate and Infection Outcome. Front Cell Infect Microbiol. 2020 Sep 30;10:457. doi: 10.3389/fcimb.2020.00457.
10: Mohareer K, Asalla S, Banerjee S. Cell death at the cross roads of host-pathogen interaction in Mycobacterium tuberculosis infection. Tuberculosis (Edinb). 2018 Dec;113:99-121. doi: 10.1016/j.tube.2018.09.007.
11: Asalla S, Mohareer K, Banerjee S. Small Molecule Mediated Restoration of Mitochondrial Function Augments Anti-Mycobacterial Activity of Human Macrophages Subjected to Cholesterol Induced Asymptomatic Dyslipidemia. Front Cell Infect Microbiol. 2017 Oct 10;7:439. doi: 10.3389/fcimb.2017.00439.
12: Balakrishnan K, Mohareer K, Banerjee S. Mycobacterium tuberculosis Rv1474c is a TetR-like transcriptional repressor that regulates aconitase, an essential enzyme and RNA-binding protein, in an iron-responsive manner. Tuberculosis (Edinb). 2017 Mar;103:71-82. doi: 10.1016/j.tube.2017.01.003.
13: Tundup S, Mohareer K, Hasnain SE. Mycobacterium tuberculosis PE25/PPE41 protein complex induces necrosis in macrophages: Role in virulence and disease reactivation? FEBS Open Bio. 2014 Sep 16;4:822-8. doi:10.1016/j.fob.2014.09.001.
14: Mohareer K, Sahdev S, Hasnain SE. Spodoptera frugiperda FKBP-46 is a consensus p53 motif binding protein. J Cell Biochem. 2013 Apr;114(4):899-907. doi: 10.1002/jcb.24429.
15: Midha M, Polavarapu R, Meetei PA, Krishnan H, Mohareer K, Vindal V. OrFin: A web tool for detection of putative orthologs. Bioinformation. 2012;8(15):738-9. doi: 10.6026/97320630008738. Epub 2012 Aug 3.
16: Mohareer K, Tundup S, Hasnain SE. Transcriptional regulation of Mycobacterium tuberculosis PE/PPE genes: a molecular switch to virulence? J Mol Microbiol Biotechnol. 2011;21(3-4):97-109. doi: 10.1159/000329489.
17: Mohareer K, Sahdev S, Hasnain SE. Baculovirus p35 gene is oppositely regulated by P53 and AP-1 like factors in Spodoptera frugiperda. Biochem Biophys Res Commun. 2011 Nov 4;414(4):688-93. doi: 10.1016/j.bbrc.2011.09.133. Epub 2011 Oct 2. PMID: 21986530.
18: Singh AK, Battu A, Mohareer K, Hasnain SE, Ehtesham NZ. Transcription of human resistin gene involves an interaction of Sp1 with peroxisome proliferator-activating receptor gamma (PPARgamma). PLoS One. 2010 Mar 29;5(3):e9912. doi:10.1371/journal.pone.0009912.
19: Mohan M, Taneja TK, Sahdev S, Mohareer K, Begum R, Athar M, Sah NK, Hasnain SE. Antioxidants prevent UV-induced apoptosis by inhibiting mitochondrial cytochrome c release and caspase activation in Spodoptera frugiperda (Sf9) cells. Cell Biol Int. 2003;27(6):483-90. doi: 10.1016/s1065-6995(03)00071-4.
20: Hasnain, S.E., Begum, R., Ramaiah, K.V.A. et al. Host-pathogen interactions during apoptosis. J. Biosci. 28, 349–358 (2003). https://doi.org/10.1007/BF02970153
Languages
Publications
1: Yandrapally S, Agarwal A, Chatterjee A, Sarkar S, Mohareer K, Banerjee S. Mycobacterium tuberculosis EspR modulates Th1-Th2 shift by transcriptionally regulating IL-4, steering increased mycobacterial persistence and HIV propagation during co-infection. Front Immunol. 2023 Oct 19; 14:1276817. doi: 10.3389/fimmu.2023.1276817.
2: Mohareer K, Banerjee S. Mycobacterial infection alters host mitochondrial activity. Int Rev Cell Mol Biol. 2023;377:87-119. doi: 10.1016/bs.ircmb.2023.01.007. Epub 2023 Mar 10.
3: Sarkar S, Balakrishnan K, Chintala K, Mohareer K, Luedde T, Vasudevan AAJ, Münk C, Banerjee S. Tough Way In, Tough Way Out: The Complex Interplay of Host and Viral Factors in Nucleocytoplasmic Trafficking during HIV-1 Infection. Viruses. 2022 Nov 12;14(11):2503. doi:10.3390/v14112503.
4: Balakrishnan K, Munusami P, Mohareer K, Priyakumar UD, Banerjee A, Luedde T, Mande SC, Münk C, Banerjee S. Staufen-2 functions as a cofactor for enhanced Rev-mediated nucleocytoplasmic trafficking of HIV-1 genomic RNA via the CRM1 pathway. FEBS J. 2022 Nov;289(21):6731-6751. doi: 10.1111/febs.16546.
5: Balakrishnan K, Jaguva Vasudevan AA, Mohareer K, Luedde T, Münk C, Banerjee S. Encapsidation of Staufen-2 Enhances Infectivity of HIV-1. Viruses. 2021 Dec 8;13(12):2459. doi: 10.3390/v13122459. PMID: 34960728; PMCID: PMC8703407.
6: Nehvi IB, Quadir N, Khubaib M, Sheikh JA, Shariq M, Mohareer K, Banerjee S, Rahman SA, Ehtesham NZ, Hasnain SE. ArgD of Mycobacterium tuberculosis is a functional N-acetylornithine aminotransferase with moonlighting function as an effective immune modulator. Int J Med Microbiol. 2022 Jan;312(1):151544. doi: 10.1016/j.ijmm.2021.151544. Epub 2021 Dec 7. PMID: 34922100.
7: Chintala K, Mohareer K, Banerjee S. Dodging the Host Interferon-Stimulated Gene Mediated Innate Immunity by HIV-1: A Brief Update on Intrinsic Mechanisms and Counter-Mechanisms. Front Immunol. 2021 Jul 29;12:716927. doi: 10.3389/fimmu.2021.716927.
8: Yandrapally S, Mohareer K, Arekuti G, Vadankula GR, Banerjee S. HIV co-receptor-tropism: cellular and molecular events behind the enigmatic co-receptor switching. Crit Rev Microbiol. 2021 Aug;47(4):499-516. doi:10.1080/1040841X.2021.1902941.
9: Mohareer K, Medikonda J, Vadankula GR, Banerjee S. Mycobacterial Control of Host Mitochondria: Bioenergetic and Metabolic Changes Shaping Cell Fate and Infection Outcome. Front Cell Infect Microbiol. 2020 Sep 30;10:457. doi: 10.3389/fcimb.2020.00457.
10: Mohareer K, Asalla S, Banerjee S. Cell death at the cross roads of host-pathogen interaction in Mycobacterium tuberculosis infection. Tuberculosis (Edinb). 2018 Dec;113:99-121. doi: 10.1016/j.tube.2018.09.007.
11: Asalla S, Mohareer K, Banerjee S. Small Molecule Mediated Restoration of Mitochondrial Function Augments Anti-Mycobacterial Activity of Human Macrophages Subjected to Cholesterol Induced Asymptomatic Dyslipidemia. Front Cell Infect Microbiol. 2017 Oct 10;7:439. doi: 10.3389/fcimb.2017.00439.
12: Balakrishnan K, Mohareer K, Banerjee S. Mycobacterium tuberculosis Rv1474c is a TetR-like transcriptional repressor that regulates aconitase, an essential enzyme and RNA-binding protein, in an iron-responsive manner. Tuberculosis (Edinb). 2017 Mar;103:71-82. doi: 10.1016/j.tube.2017.01.003.
13: Tundup S, Mohareer K, Hasnain SE. Mycobacterium tuberculosis PE25/PPE41 protein complex induces necrosis in macrophages: Role in virulence and disease reactivation? FEBS Open Bio. 2014 Sep 16;4:822-8. doi:10.1016/j.fob.2014.09.001.
14: Mohareer K, Sahdev S, Hasnain SE. Spodoptera frugiperda FKBP-46 is a consensus p53 motif binding protein. J Cell Biochem. 2013 Apr;114(4):899-907. doi: 10.1002/jcb.24429.
15: Midha M, Polavarapu R, Meetei PA, Krishnan H, Mohareer K, Vindal V. OrFin: A web tool for detection of putative orthologs. Bioinformation. 2012;8(15):738-9. doi: 10.6026/97320630008738. Epub 2012 Aug 3.
16: Mohareer K, Tundup S, Hasnain SE. Transcriptional regulation of Mycobacterium tuberculosis PE/PPE genes: a molecular switch to virulence? J Mol Microbiol Biotechnol. 2011;21(3-4):97-109. doi: 10.1159/000329489.
17: Mohareer K, Sahdev S, Hasnain SE. Baculovirus p35 gene is oppositely regulated by P53 and AP-1 like factors in Spodoptera frugiperda. Biochem Biophys Res Commun. 2011 Nov 4;414(4):688-93. doi: 10.1016/j.bbrc.2011.09.133. Epub 2011 Oct 2. PMID: 21986530.
18: Singh AK, Battu A, Mohareer K, Hasnain SE, Ehtesham NZ. Transcription of human resistin gene involves an interaction of Sp1 with peroxisome proliferator-activating receptor gamma (PPARgamma). PLoS One. 2010 Mar 29;5(3):e9912. doi:10.1371/journal.pone.0009912.
19: Mohan M, Taneja TK, Sahdev S, Mohareer K, Begum R, Athar M, Sah NK, Hasnain SE. Antioxidants prevent UV-induced apoptosis by inhibiting mitochondrial cytochrome c release and caspase activation in Spodoptera frugiperda (Sf9) cells. Cell Biol Int. 2003;27(6):483-90. doi: 10.1016/s1065-6995(03)00071-4.
20: Hasnain, S.E., Begum, R., Ramaiah, K.V.A. et al. Host-pathogen interactions during apoptosis. J. Biosci. 28, 349–358 (2003). https://doi.org/10.1007/BF02970153
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