Laxmikant B. Nikam
Bahadurgarh
Summary
Dynamic R&D leader with extensive experience at Bharat Rasayan Limited, specializing in process development and commercialization. Proven track record in project management and cost reduction, successfully scaling up complex APIs. Adept at regulatory compliance and fostering collaboration across teams, ensuring high-quality outcomes in competitive environments.
Overview
27
27
years of professional experience
Work History
Associate Vice President (Head R&D)
Bharat Rasayan Limited
Bahadurgarh
10.2023 - Current
- Leading a team of scientists and analysts, developing novel and non-infringing processes for APIs and pesticide intermediates
- Co-ordinates with analytical, purchase, marketing departments, suppliers, and foreign clients
- Developed and scaled up agrochemicals: the process of Chlorpropham, Lambda-cyhalothrin, Tebufenozide, Thifluzamide, Aminopyrifen, Halosulfuron methyl, HPOA.HCl and Iptriazopyrid
- Fluoro molecules, Handling of Reactions: HF and KF Halex, Balz-Schiemann Reactions, Chlorination, Bromination, Cyanation, Hydrogenation, Grignard Reaction, Friedel craft reaction, Cryogenic reaction, various organic reactions, etc
- Commercialization of below molecules: 2,6-Dichloro-4-trifluoromethyl aniline, RfA (flubendiamide intermediate) five HF halex molecules, Seven KF halex molecules, Four Balz-Schiemann molecules, and several specialty chemicals
- Commercialization of APIs: Promedol hydrochloride, Elinogrel intermediate, 6—chloro-O-toluidine, Bupivacaine and mepivacaine intermediate, Fentanyl citrate, and bisoprolol himifumrate
- Attend inquiries and give quotations to customers
- Work on an FTE basis and share the weekly update with customers
- Collaborative work for foreign companies like BI (Boehringer Ingelheim), Cilag, and others
- This work involved the development of non-infringing processes for several drug intermediates & twelve impurities of phase II drug, developed several heterocyclic drug intermediates (i.e
- Multistep synthesis) & subsequently scaled up in a kilo lab
- Manage to complete the projects successfully within the time limit with competitive price & quality
- Knowledge of data generation for Drug Master File, such as process validation, impurity profile, etc
- Carry out reactions at 1- 2 kg scale to study process feasibility, stability, and data generation for the kilo lab / Pilot plant and evaluate critical parameters
- Transfer the technology to the pilot and commercial plant (Launch of a new product)
- Supported pilot and commercial plants and solved troubleshooting issues
- Cost reduction of the existing process
- Preparation of documents like weekly reports, monthly reports, technology transfer dossiers (tech pack), PowerPoint presentations, maintaining the lab notebooks, SOPs, etc
- Fixed the specification of raw materials, in-process & intermediates according to the impurity profile of the finished product
- Review and approve SOPS, BPR (batch process report), change control & deviation report
- Conducting different trials for yield improvement and minimum waste generation
- Data generation of stability study of reaction mass, intermediates & finished products
- Synthesis of intermediate of Elinogrel, Bupivacaine & Mepivacaine hydrochloride on a commercial scale (tonnage)
- Synthesized several drug intermediates i.e
- Intermediate of bupropion, fluoxetine, celecoxib, buprenorphine, telithromycin, Linagliptin, Fipronil, etc
- Synthesis of several CRAMS molecules
- Synthesis of impurities of bisoprolol, tramadol, fentanyl, detomidine and prochloroperazine
- Thorough knowledge of Literature search of new products via Scifinder, Row2, internet, Chemical Abstracts & various Journals
- Raw material input and output balance
- Understanding the pattern of reaction at the kilo lab
- Substantial experience in sophisticated research techniques and technologies like column chromatography, fractional distillation, autoclave reactions, preparative TLC, and recrystallization
- Good knowledge of interpretation of GC, HPLC, Mass & NMR
- Demonstrated ability to efficiently prioritize a broad range of responsibilities to achieve maximum level of operating effectiveness
- Handle toxic and hazardous chemicals like sodium cyanide, copper cyanide, hydrogen fluoride, butyl lithium, etc
General Manager (Head R&D)
Gujarat Fluorochemicals Ltd
Taluka Ghoghamba
04.2019 - 10.2023
Deputy General Manager
Gujarat Fluorochemicals Ltd
04.2018 - 03.2019
Assistant General Manager
Gujarat Fluorochemicals Ltd
04.2015 - 03.2018
Chief Manager
Gujarat Fluorochemicals Ltd
04.2014 - 03.2015
Sr. Manager R & D
Gujarat Fluorochemicals Ltd
09.2012 - 03.2014
Group Leader
Jubilant Life Sciences Ltd
Noida
07.2010 - 09.2012
Senior Research Scientist
Jubilant Life Sciences Ltd
01.2008 - 06.2010
Research Scientist
Jubilant Life Sciences Ltd
03.2004 - 12.2007
Research Chemist
Rusan Pharma Limited
Kandivali (W)
05.2001 - 03.2004
Research Chemist
Bombay Drugs and Pharma Ltd
Kandivali (E)
12.1997 - 04.2001
Education
Ph.D. - Organic Chemistry
C.C. S. University
Meerut, U.P.01.2007
M.Sc. - Chemistry
North Maharashtra University
Jalgaon, Maharashtra01.1997
B.Sc. - Chemistry
North Maharashtra University
Jalgaon, Maharashtra01.1995
Skills
- Process development
- Commercialization processes
- Project management
- Regulatory compliance
- Process optimization
- Cost reduction
Degree
Ph. D.
Languages
- Marathi
- Hindi
- English
Awards
- Chairman’s Award of the Year, 2011, For the development of an innovative process for drug intermediate.
- Third Prize, 1997, For participation in an open house organized by the School of Chemical Science at North Maharashtra University.
- Participation Certificate, 2009, In Process Chemistry in the Pharmaceutical Industry: Challenges in an Ever-Changing Climate at R&D Center Jubilant Organosys Ltd.
- Provisional Certificate, 2010, PMP (Project Management Process) by PMAC.
- Project Management Course, 2010, Effective Project Management.
Publications
- Ashok Kumar, L. B. Nikam, Bhaskar Shetty, Chatrasal Singh Rajput, Vikas Singh, Jai Singh, Thiozolidinyl and Azetidinyl quinazolinones as potent antibacterial agents., Ori. J. of Chem. India, 2006, 22, 219-230
- Ashok Kumar, Sonia Verma, Bhaskar Shetty, Laxmikant B. Nikam, R.P. Mishra, Sudhir Kumar Bhati, Pankaj Kumar, Chatrasal Singh Rajput, Vikas Singh, Parul Rani, Seema Rani, Yashovardhan, Jai Singh, Synthesis and anti-inflammatory, analgesic, ulcerogenic and cyclooxygenase – II Inhibitory activities of Indolyl – pyrazolines and Indolylthizolidinyl Pyrazolines., Ori. J. of Chem. India, 2006, 22, 259-268
Training
Six Sigma Training, Yellow Belt
Patents
- Novel imidazole compound, preparation method, and use thereof., 2057/DEL/2009, 201010544302, India, China
- Preparation of 2,6-Dichloro-paratrifluoromethylaniline, TEMP/E-1/11890/2018-MUM, 201821011414
- Process for Preparation of 2-Bromo-5-Fluoro Benzotrifluoride, TEMP/E-1/19262/2018-MUM, 201821018246
Personal Information
- Citizenship: Indian
- Date of Birth: 03/20/73
- Gender: Male
- Marital Status: Married
Timeline
Associate Vice President (Head R&D)
Bharat Rasayan Limited
10.2023 - Current
General Manager (Head R&D)
Gujarat Fluorochemicals Ltd
04.2019 - 10.2023
Deputy General Manager
Gujarat Fluorochemicals Ltd
04.2018 - 03.2019
Assistant General Manager
Gujarat Fluorochemicals Ltd
04.2015 - 03.2018
Chief Manager
Gujarat Fluorochemicals Ltd
04.2014 - 03.2015
Sr. Manager R & D
Gujarat Fluorochemicals Ltd
09.2012 - 03.2014
Group Leader
Jubilant Life Sciences Ltd
07.2010 - 09.2012
Senior Research Scientist
Jubilant Life Sciences Ltd
01.2008 - 06.2010
Research Scientist
Jubilant Life Sciences Ltd
03.2004 - 12.2007
Research Chemist
Rusan Pharma Limited
05.2001 - 03.2004
Research Chemist
Bombay Drugs and Pharma Ltd
12.1997 - 04.2001
Ph.D. - Organic Chemistry
C.C. S. University
M.Sc. - Chemistry
North Maharashtra University
B.Sc. - Chemistry
North Maharashtra University
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