MADHUMATHI IRULAPPAN

I work on the Molecular Genetics of Antimicrobial Resistance (AMR) of clinical pathogens.

• Microbiology Society, C045865, United Kingdom
• American Society for Microbiology

• SRF - Basic Scientific Research Fellowship, 06/01/17, 06/01/20, University Grants Commission, India, Molecular Genetic Analysis of the regulation of macromolecular processes in Bacteria.
• JRF - Basic Scientific Research Fellowship, 06/01/15, 06/01/17, University Grants Commission, India, Molecular Genetic Analysis of the regulation of macromolecular processes in Escherichia coli.
• SRF -IPLS, 09/01/14, 03/01/15, University Grants Commission (Centre for Excellence in Genomic Sciences), India, Molecular Genetic Analysis of the regulation of macromolecular processes Escherichia coli
• JRF -IPLS, 09/01/12, 08/01/14, University Grants Commission (Centre for Excellence in Genomic Sciences), India, Studies on Genetic Regulation in Escherichia coli

• Differential Gene Expression in Plants and Bacteria, UGC - NRCBS, Madurai, Tamil Nadu, 02/01/17, 02/14/17
• Bacterial Whole Genome Sequencing and Genome Data Mining, Christian Medical College and ICMR, Delhi, 10/03/22, 10/09/22
• Hands-on-training on Diphtheria and Pertussis Laboratory Techniques, WHO and CMC, Vellore, Vellore, 04/24/23, 04/29/23

• The Lancet Infectious Diseases
• Nature Communications
• International Journal of Biological Macromolecules

• M.Sc., Biochemistry, M.Sc. dissertating Co-Guide, 2014, 2020
• M.Sc., Genomics, Laboratory in Bacterial Genetics and Molecular Biology, 2020, 2021

• Arijit Pal, Dipannita Ghosh, Pratyusha Thakur, Priya Nagpal, Madhumathi Irulappan, Karthik Maruthan, Sanket Mukherjee, Nikita G Patil, Tanmay Dutta, Balaji Veeraraghavan, Perumal Vivekanandan, Clinically relevant mutations in regulatory regions of metabolic genes facilitate early adaptation to ciprofloxacin in Escherichia coli, Nucleic Acids Research, 2024, 16.6
• Sethuvel DP, Bakthavatchalam YD, Karthik M, Irulappan M, Shrivastava R, Periasamy H, Veeraraghavan B, β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview, Infectious Diseases and Therapy, 2023 Mar, 12, 3, 829-41, 6.1
• Irulappan M, Mutreja A, Veeraraghavan B, Genomic surveillance for comprehensive Shigella management, The Lancet Infectious Diseases, 2023 Jun 1, 23, 6, 645-7, 71.4
• Ashwin Sri Bala S, Madhumathi I Vinodha S, Munavar MH, Glu571 of PheT plays a pivotal role in the thermal stability of Escherichia coli PheRS enzyme, Journal of basic microbiology, 2018 Jun, 58, 6, 475-91, 3.97

• Genetic evidence for the possible functional similarity between antibiotic Hygromycin and the Biological Toxin Doc in Escherichia coli and its Implications, International Conference on Bacterial Expressions, 12/01/15, Bangalore, Selected for special Oral Presentation
• Molecular Genetic Analysis of HygR Mutants of Escherichia coli Reveal a Possible Interlink Between Hygromycin Resistance and Programmed Cell Death in Bacteria, International Conference on Recent Trends in Biosciences, 04/07/16, Karaikudi, Best Oral Presentation Award
• Fosfomycin and aminoglycoside resistance co-carriage in carbapenem resistant E. coli and associated treatment complications, 12th Annual Research Day, 10/06/22, Vellore, First Prize in the poster presentation
• Molecular Genetic characterization of fosfomycin resistance mechanism and antibiotics combinations to combat, MICROCON-2022, Bhubaneswar, Selected for Bacteriology Oral award
• The Pertussis Puzzle: Unraveling Resurgence and Vaccine Evolution for a Safer Future, MICROCON-2023, Lucknow, First Prize in Oral Presentation
• Decoding Fosfomycin Resistance in E. coli and K. pneumoniae: Insights into Heterogeneous Mechanisms, Winter Symposium & South Zone MicroCon 2024, Vellore, Third Prize in Oral Presentation

• Genetic evidence for a possible interlink between hygromycin resistance and bacterial apoptosis, National Conference on Recent Trends in Modern Biology & 46th Aqua-Terr Annual Conference on Biological Sciences, 02/27/15
• Genetic evidence for interaction between β-subunit of RNA polymerase and pheT product and its implications in transcription control by Fit factor in Escherichia coli, National Conference on Recent Trends in Modern Biology & 46th Aqua-Terr Annual Conference on Biological Sciences, 02/27/15
• Isolation and characterization of Amikacin resistant mutants in Escherichia coli and their implications in multi drug resistance, National Conference on Recent Trends in Modern Biology & 46th Aqua-Terr Annual Conference on Biological Sciences, 02/27/15
• The Base-Pair Co-ordinate G293 of pheS Gene of Escherichia coli Defines a 'Hot Spot' for occurrence of Temperature Sensitive Mutants: Implications and its impact, International Conference on Recent Trends in Biological Research, 12/22/15, Sivakasi
• Isolation and Genetic Characterization of Chromosomal Mutations Leading to Hygromycin Resistance in Escherichia coli: Impact of Glucose and Extracellular Death factor During Selection, National Conference on Recent Trends in Modern Biology & 47th Aqua-terr Annual Conference on Biological Sciences, 02/27/16
• Ascertaining the role of acrE in Amninoglycosidic Antibiotic Specific Multidrug Resistance in Escherichia coli, National Conference on Recent Trends in Modern Biology & 47th Aqua-Terr Annual Conference on Biological Sciences, 02/27/16
• Suppression of Hypersensitivity to Antibiotics in Escherichia coli lexA3 Strain by mutant forms of RNA polymerase, Aqua-Terr Golden Jubilee International Conference on Genome Biology and Host Defence: Bacteria to Mammals, 02/27/19
• Complementation analyses of the novel temperature sensitive pheT mutant pheT45 multi copy pheU+ clone in Escherichia coli, Aqua-Terr Golden Jubilee International Conference on Genome Biology and Host Defence: Bacteria to Mammals, 02/27/19
• The Pertussis Puzzle: Unraveling Resurgence and Vaccine Evolution for a Safer Future, Kalaignar Centenary International Medical Conference on the Future of Medicine, 01/19/24, Chennai

• Won Maruthu Pandiar Endowment Scholarship in the year 2008 for having secured the highest mark in the University Examination for the academic year 2007-2008 by Madurai Kamaraj University.
• President award holder in Bharath Scouts and Guides.
• Done two years (2007-2008) service to the society under National Service Scheme.
• Won the ninth National level Youth Parliament Competition held at Madurai Kamaraj University on 26.02.2010.

1. Title: Unravelling the diversity of hybrid/hetero-pathogenic E. coli strains in community and hospital settings using metagenomic approach

Funding Agency: Christian Medical College, Vellore, India,

Role: Co-investigator 

2. Tilte: Molecular Genetic investigation of Fosfomycin resistance among the clinical isolates of E. coli

 Funding Agency: Christian Medical College, Vellore, India

Role: Co-investigator 

3. Title: Development of rapid molecular diagnostic kit for antimicrobial resistance profiling in health-care-associated bloodstream and urinary tract infections management.

Funding Agency: Indian Council of Medical Research, 

Role: Co-investigator 

4. Title: Exploring the mechanisms of hypermutability and antimicrobial resistance evolution in Pseudomonas aeruginosa can aid in better understanding its implications    for infection management. 

Funding Agency: Indian Council of Medical Research

Role: Co-investigator 

5. Title: A point of care kit for rapid development of serotype-specific Shigella infections (Shigellosis)

Funding Agency: Bill & Melinda Gates Foundation

Role: Co-investigator 

6. Title: To investigate on how antibiotic resistance spreads among different types of Shigella Bacteria

Funding Agency: Medical Research Council (MRC) - UKRI,

Role: Co-investigator 

7. Title: In vitro analysis of the susceptibility of probiotics against oral/|V antimicrobials

Funding Agency: Dr. Reddy's Laboratory, India.

Role: Co-investigator

8. Title: Metagenomic insights into the antibiotic resistome in urban environments

Funding Agency: Christian Medical College, Vellore, India and Vellore Institute of Technology, Vellore, India

Role: Co-investigator