Madhura Basavalingegowda
Senior Scientist
Bangalore
Summary
Dynamic professional with over 13 years of expertise in NGS personalized genomics, clinical interpretation, and data curation, along with extensive experience in clinical and consumer genomics. Demonstrated ability to efficiently manage multiple projects while fostering collaboration among diverse teams, including scientific and technical stakeholders in NGS genomics. Seeking to leverage a robust skill set in a challenging role within the industry or corporate sector, particularly focused on Multi-Omics or related fields. Committed to driving innovation and excellence in genomic research and applications.
Overview
2
2
Certifications
15
15
years of professional experience
Work History
Senior Scientist
1cell.ai
09.2022 - Current
- Co-led a team of genome analysts in the interpretation of Next Generation Sequencing (NGS) data, ensuring high-quality, clinically relevant variant analysis.
- Created clear, standardized genetic reports for clinical interpretation, and downstream decision-making.
- Developed and maintained variant classification SOPs, and interpretation frameworks.
- Involved in the evaluation of critical CAP samples, validation sample analyses, and performed statistical analysis for the Alpha Lung Study.
- Involved in panel design for comprehensive panels, and targeted panels.
- Worked closely with reporting leads to enhance the overall quality, accuracy, and clarity of genetic reporting processes.
- Trained, mentored, and evaluated genome analysts, fostering continuous professional development and adherence to best practices.
- Partnered with product, validation, operations, and customer success teams to analyze innovation trends and propose workflow improvements.
- Conducted comprehensive literature searches and critically evaluated evidence from global guidelines (NCCN, ASCO, ESMO), and regulatory sources (FDA/EMA) to derive clinically relevant insights.
Scientist
Xcode Life Sciences
11.2021 - 08.2022
- Managed multiple projects and their interpretation for Personalized genomics and Wellness.
- Variant Analysis for Microarray data and report preparation for clients wrt to genetic variations, wellness, pgx, fitness and nutrigenomics
- SNP (array/custom) selection and prioritization using phenotype databases (GWAS, SNPedia & ClinVar)
- Communication with product team and clinicians for project deliverables and business communication.
Senior Genome Analyst
Bione Ventures Limited
03.2020 - 10.2020
- Clinical prediction of Genetic Disease Risk Assessment for Rare Diseases, Carrier Status and Hereditary Diseases.
- Consulting ideas and scientific inputs to Consumer Genomics and Pharmacogenomics
- Clinical Variant Analysis for WGS/WES/Microarray data and report preparation for clients wrt to genetic variations, wellness, fitness and nutrigenomics
- SNP (array/custom) selection and prioritization using phenotype databases (GWAS, Regulomedb, SNPedia & ClinVar)
- Communication with product team and clinicians for project deliverables and business communication.
Assistant Manager - Genomics
Indus Health Plus Limited
09.2018 - 03.2020
- Multiple scientific data curation for rare and complex diseases, nutrition based traits, SNP markers, and customizing SNP based prediction analysis (to prioritize significant based markers).
- Managed multiple projects and their interpretation for Personalized genomics and cancer genomics.
- Consulting team and sharing thoughts with scientific advisory panel related to development of in-house databases - genomics variants, disease - SNP correlation, nutrition and fitness and their guidelines (vocabularies based).
- Extensive database search using UCSC, PubMed, SNPedia, dbSNP, 1000 genomes, SCAN, SNPnexus, COSMIC, and GWAS.
- Meeting deliverables and targets for clinical/customized array reports, data from case analyzation, data abstraction, and database management (curation and optimization).
Senior Scientific Officer
Positive Bioscience
02.2013 - 09.2018
- Worked as team leader managing and syncing up with work environment for 6 team members.
- Performed microarray (Illumina platform) based data analysis and interpretation with in-house PositiveMD Cancer database.
- Experience in disease risk prediction, gene-gene interactions, quantitative pathway analysis (using KEGG), and drug target identification.
- Targeted Sequencing (NGS) based data analysis and interpretation - pharmacogenomics of underlying variations responsible for cancer, their risk predisposition and molecular insights for choosing appropriate targeted therapies [Tools: Annovar, Genome Visualization (IGV) tool, CLINVAR, COSMIC, 1000genomes, dbSNP, In-house PositiveMD].
- Data processing through existing NGS data analysis pipelines.
- Identifying, evaluating and documenting new methodologies to support ongoing genomic research/trial needs.
- Manage project schedule and task details and utilize project management tools such as reports, tracking charts, checklists.
- Preparing and evaluating clinical report produced during analysis to product team or concerned physician.
Research Curator
Cambridge Technology Enterprise Limited
10.2011 - 02.2013
- To evaluate, annotate, and integrate the given phenotype into the database.
- Analysis of gene-disease associations from scientific publications.
- To correlate between disease status and genetic variation to identify candidate genes or genome regions that contributes to a specific disease.
- Interpret and assess scientific results that require an in-depth understanding of molecular biology and genetics.
- Mainly involved in identifying and classifying the variants, genes, and gene sets that are likely to underlie a specific disease, tumour, or drug response.
Education
Master of Science - Applied Genetics
The Oxford College of Science
Bengaluru08-2011
Bachelor of Science - Microbiology
B.M.S College, Bangalore University
Bangalore08-2009
Certification
Recombinant DNA Technology; GENE Cloning Techniques [with Practical Exposure].
Interests
Hobbies: Scientific Reading, Volunteering Event and Organizing them, Team Management and Social skills
Awards
Merit Prize in 1st Year of MSc Applied Genetics 2010., ENDOWMENT CASH AWARD PRIZE for Best Academic Performance in MSc Applied Genetics in 2010-2011.
Publications
- Ramesh, Aarthi, Atul Bharde, Alain D’Souza, Bhagwat Jadhav, Sangeeta Prajapati, Kanchan Hariramani, Madhura Basavalingegowda et al. "Clinical and technical validation of OncoIndx assay—a comprehensive genome profiling assay for pan-cancer investigations." Cancers 16, no. 19 (2024): 3415.
- Sandhya, I., Ramesh, A., Shubham, K., Rajeev, V., Seema, T., Madhura, B., & Gowhar, S. (2010). Clinical genomics: Next generation guide in difficulty-to-treat cancers.
- Iyer, Sandhya, Rambaksh Prajapati, Aarthi Ramesh, Madhura Basavalingegowda, Seema Todur, Shubham Kavvishar, Rajeev Vijaykumar et al. "The future of lung cancer therapy: Striding beyond conventional EGFR and ALK treatments." Molecular and Clinical Oncology 10, no. 4 (2019): 469-475.
- Sandhya Iyer, Shruti Desai, Rambaksh Prajapati, Madhura Gowda, Shubham Kavvshar, Gowhar Shafi.2017. Nutrigenomics: Delivering care and personalized lifestyle centred aroung you. Precision Medicine, vol 2, 2017, 6-16.
- Gowhar Shafi
- Sandhya Iyer, Shruti Desai, Madhura Basavalingegowda, Shubham Kavvishwar, Rambaksh Prajapati, Chandrani Achari and Prajakta Kadam.,2018. Liquid Biopsy: Golden Era of Personalized Medicine in Oncology. Journal of Cancer Research and Clinical Oncology 2(1):1-12
Declaration
I hereby declare that all the information given above is true is best of my knowledge. Madhura Basavalingegowda
Timeline
Senior Scientist
1cell.ai
09.2022 - Current
Scientist
Xcode Life Sciences
11.2021 - 08.2022
Senior Genome Analyst
Bione Ventures Limited
03.2020 - 10.2020
Assistant Manager - Genomics
Indus Health Plus Limited
09.2018 - 03.2020
Senior Scientific Officer
Positive Bioscience
02.2013 - 09.2018
Research Curator
Cambridge Technology Enterprise Limited
10.2011 - 02.2013
Bachelor of Science - Microbiology
B.M.S College, Bangalore University
Master of Science - Applied Genetics
The Oxford College of Science