Summary
Overview
Work History
Education
Skills
Accomplishments
Publications
Languages
Timeline
Generic

Manish Lal Das

Summary

Research scientist with 14+ years of professional experience in Drug Discovery & Biotechnology research in pharmaceutical and biopharma industry. Handling multiple programs across therapeutic areas for different clients and involved in assay design, target validation, execution of key in-vitro cell based and biochemical assays for various therapeutic areas. Proficient in lab automation for research activities with the application of robotics.

Overview

16
16
years of professional experience

Work History

Research Scientist

Sai Life Sciences
Hyderabad
12.2023 - Current
  • Working as team lead and handling multiple client projects across different therapeutic areas.
  • Lead multiple client projects and met deliverables within the set timeline
  • Developing healthy relation and communication with clients to share proposal, research findings and discuss project status
  • Successfully established biochemical and cell-based assays for novel targets
  • Automated assays for minimal human intervention, improved throughput, data quality and TAT
  • Contributed for the establishment of novel capability platform of HTS screening for library screening
  • Training and mentoring junior members in technical aspects and compliance related issues relevant to lab setting

Associate Scientist to Research Scientist

Biocon Bristol-Myers Squibb R&D Centre (BBRC), Syngene International Pvt. Ltd.
Bengaluru
05.2015 - 11.2023
  • Involved in the development and validation of various mechanistic assays for early targets as proof-of-concept studies in different therapeutic areas, such as fibrosis, immunology, and oncology.
  • Designing and developing in vitro assays, proof of concept studies, and validation of targets; establishment of PK/PD assays for targets; and evaluation of new chemical entities for their efficacy, safety, and toxicity.
  • Significant contributions toward the development of clinical molecules for major depression and neuropathic pain.
  • Contributed to the decision point transition in the pulmonary fibrosis project and ECN (Early Clinical Nominee) delivery in neuropathic pain and major depression.

Research Associate to Associate Scientist

Biocon Bristol-Myers Squibb R&D Centre (BBRC), Syngene International Pvt. Ltd.
Bengaluru
05.2010 - 04.2015
  • Involved in development, validation of In Vivo and ex vivo assays and animal models in behavioral neuroscience for compound screening
  • Established and validated radioligand binding and imaging assays for transporters and receptors in rat and mouse tissues
  • Isolation of organs and specific areas of organs from rat and mouse tissues to measure various biochemical markers in isolated samples

Project Trainee

Panacea Biotec Limited
SAS Nagar
05.2009 - 04.2010
  • Completed one year academic project as a part of Master’s degree in Pharmacology entitled “Comparative evaluation of different monoaminergic neurotransmitter reuptake inhibitors in animal models of behavioral despair”

Education

M.Pharm - Pharmacology

Manipal College Of Pharmaceutical Sciences
Manipal, Karnataka
05-2010

GATE -

GATE
IISc Bangalore
04-2008

B.Pharm -

Manipal College Of Pharmaceutical Sciences
Manipal, Karnataka
05-2008

Skills

  • Cell-based assays for screening and proof-of-concept studies
  • Biochemical assays (TR-FRET, AlphaLISA) for high-throughput screening
  • Protein expression analysis by Western blot, Protein Simple, In-Cell Western, and High Content assay
  • Transient transfection and stable clone generation
  • Radioactive target occupancy assay
  • Rodent handling, dosing, and tissue collection
  • Proficient in preparing cryosections of various mouse and rat tissues
  • Proficient in handling various radioisotopes (liquid source), like 3H and 125I
  • Experience in maintaining a Type II radioactivity lab and following AERB guidelines

Accomplishments

  • Successfully completed training course on radiation safety aspects in research applications of ionising radiation by atomic energy regulatory board (AERB), BARC, Mumbai in August 2011
  • Received BMS R&D Star awards for validation of Brain and Spinal cord Occupancy assay for pain program Received BMS R&D Star awards for validation of target autoradiography occupancy assay and receptor occupancy assay for depression project
  • Received R&D Star awards for running functional assay for Fibrosis exploratory programs
  • Received BMS R&D Excellence award for successful transition of program from pre clinical to clinical stage

Publications

  • Bacillus Calmette-Guérin vaccine induces a selective serotonin reuptake inhibitor (SSRI)-resistant depression like phenotype in mice Brain Behav Immun. 2014 Nov;42:204-11. doi:10.1016/j.bbi.2014.06.205. Epub 2014 Jul 9
  • Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain J Pharmacol Exp Ther 2016 Sep 13;358(3):371-86. Epub 2016 Jul 13
  • Characterization of the adrenocorticotrophic hormone - induced mouse model of resistance to antidepressant drug treatment Pharmacol Biochem Behav. 2017 Oct;161:53-61 doi: 10.1016/j.pbb.2017.09.003. Epub 2017 Sep 11
  • Diminished responses to monoaminergic antidepressants but not ketamine in a mouse model for neuropsychiatric lupus J Psychopharmacol. 2018 Nov 28:269881118812102. doi:10.1177/0269881118812102

Languages

English
First Language
Hindi
Proficient (C2)
C2

Timeline

Research Scientist

Sai Life Sciences
12.2023 - Current

Associate Scientist to Research Scientist

Biocon Bristol-Myers Squibb R&D Centre (BBRC), Syngene International Pvt. Ltd.
05.2015 - 11.2023

Research Associate to Associate Scientist

Biocon Bristol-Myers Squibb R&D Centre (BBRC), Syngene International Pvt. Ltd.
05.2010 - 04.2015

Project Trainee

Panacea Biotec Limited
05.2009 - 04.2010

M.Pharm - Pharmacology

Manipal College Of Pharmaceutical Sciences

GATE -

GATE

B.Pharm -

Manipal College Of Pharmaceutical Sciences

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Manish Lal Das