Manyam Subbi Reddy

Dynamic research professional with a strong track record at CSIR-Indian Institute of Chemical Technology and TCG Life Sciences Pvt. Ltd., specializing in multistep organic synthesis, organocatalysis, photochemistry, and process development. Highly experienced in synthesizing biologically active compounds, project execution, and data-driven analysis. Known for driving innovative solutions, building robust research projects, and delivering high-impact results in fast-paced, collaborative R&D environments.

• 2017 & 2019 National Eligibility Test (CSIR-NET) awarded by CSIR, India
• 2018, Qualified Graduate Aptitude Test in Engineering (GATE) in Chemistry
• 2022, Senior Research Fellowship awarded by ICMR, India

• Intramolecular Vinylogous Michael Reaction & Doubly Vinylogous Michael Addition Reactions, The effectiveness of the intramolecular vinylogous Michael addition and the subsequent isomerization has been successfully demonstrated. Reactions involving o-hydroxy-cinnamates, cinnamonitrile and chalcones with γ-bromocrotonates led to the production of 2,3-disubstituted benzofuran derivatives.
• Base-mediated Arylogous Nitroaldol Reaction and Styrylogous Aldol Condensation, A straightforward and transition metal-free method has been developed for synthesizing a variety of 2-(2-nitroaryl)benzofuran/indole derivatives.
• Exploring the Reactivity of Imines through N-Heterocyclic Carbene-Catalyzed Umpolung and Its Applications, An innovative first reported on N-heterocyclic carbene (NHC) catalysis imine umpolung method has been synthesized various substituted 2-aryl/heteroaryl/vinyl indole-3-acetic acid derivatives.
• Ru-Catalyzed Synthesis of O-Bridged Tricyclo-fused Cyclopropane Derivatives, An efficient process has been established that uses visible light-mediated photocatalyzed energy transfer reaction to produce oxygen-bridged tricyclo-fused cyclopropane derivatives.
• CSIR-API Mission Mode Projects, Nilotinib (Tasigna): Indicated for the treatment of specific types of chronic myeloid leukemia (CML; a cancer of the white blood cells).

• Date of Birth: 14/05/1992
• Gender: Male
• Nationality: Indian
• Marital Status: Married

• Reddy, M. S.; Kamala, K.; Suresh, S. A Formal [4+1] Annulation incorporating Styrylogous Aldol Condensation to Access Functionalized 2-Styryl-benzofurans., Org. Biomol. Chem., 2025, 23, 5096-5100, DOI:10.1039/D5OB00348B
• Reddy, M. S.; Satyam, K.; Suresh, S. Design and Application of Intramolecular Arylogous Nitroaldol Condensation to Access 2-Arylbenzofuran and -Indole Derivatives and Formal Synthesis of Saprisartan., RSC Adv., 2024, 14, 37234-37239, DOI:10.1039/D4RA07741E
• Ramarao, J.; Behera, P. C.; Reddy, M. S.; Suresh, S. Carbene-Catalyzed Tandem Imine Umpolung−Intramolecular Aza-Conjugate Addition−Oxidation to Access N-Substituted Isoindolinones., J. Org. Chem., 2024, 89, 414−424, DOI:org/10.1021/acs.joc.3c02187
• Sinha, P. K.; Reddy, M. S.; Behera, P. C.; Nanubolu, J. B.; Suresh, S. Photocatalyzed Energy Transfer for Atom Economical Synthesis of O-Bridged Tricyclo-Fused Cyclopropane Derivatives., Eur. J. Org. Chem., 2023, 26, e2023008, DOI:org/10.1002/ejoc.202300805
• Reddy, M. S.; Nanubolu, J. B.; Suresh, S. Design and Development of Intramolecular Doubly Vinylogous Michael Addition to Access 3-Aryl Substituted 2-Alkenyl-benzofurans and -Indoles., Org. Biomol. Chem., 2023, 21, 5387-5397, DOI:10.1039/D3OB00861D
• Harish, B.; Reddy, M. S.; Suresh, S. Total Syntheses of h5-HT2A Receptor Antagonist, FPTase Inhibitor, FGIN-1-27 and its Analog by Exploiting NHC-Catalyzed Imine Umpolung as Key Step., Asian J. Org. Chem., 2023, 12, e2022006, DOI:org/10.1002/ajoc.202200672
• Harish, B.; Reddy, M. S.; Obulesu, O.; Suresh, S. One-Pot Allylation-Intramolecular Vinylogous Michael Addition-Isomerization Cascade of o-Hydroxycinnamates and Congeners: Synthesis of Substituted Benzofuran Derivatives., Org. Lett., 2019, 21, 1823-1827, DOI:org/10.1021/acs.orglett.9b00414
• Harish, B.; Reddy, M. S.; Suresh, S. N-Heterocyclic Carbene (NHC)-Catalysed Atom Economical Construction of 2,3-Disubstituted Indoles., Chem. Commun., 2017, 53, 3338-3341, DOI:10.1039/C6CC10292A
• Dutta, H.#, Harish, B.#, Reddy, M. S.#, Suresh, S. And Jain, N. Design and Synthesis of 2-Substituted Indole-3-acetic Acid Derivatives as Mitotic Blockers., under communication, (# = equal contribution)

• Dr. Surisetti Suresh, Senior Principal Scientist, Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India, 500007, surisetti@iict.res.in, +91-942335336
• Dr. S. Nishant Jain, Principal Scientist, Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India, 500007, nishant@iict.res.in, +91-9490460351
• Dr. Rambabu Chegondi, Senior Principal Scientist, Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India, 500007, rchegondi@iict.res.in, +91-9396477661

March 2024, Awarded the Best Poster Award at the IICT, 2024 NIICT International Symposium, for the presentation titled 'Design and Application of Intramolecular Doubly Vinylogous Michael Addition: Synthesis of 3-Aryl Substituted 2-Alkenyl-Benzofuran and -Indole Derivatives.'

• Project Assistant-II, CSIR-IICT, 2016-17, Combination of organo catalysis and transition metal catalysis (DST-SERB)
• Research Chemist, TCG Life Science Pvt. Ltd, 2017-18, Privileged molecule scaffolds in 17-synthetic steps and macro cyclic peptide synthesis
• Project Assistant-II, CSIR-IICT, 2018-19, INPROTICS-Pharma and Agro (CSIR-API Mission Mode Project)
• Junior Research Fellowship (P), CSIR-IICT, 2019-20, Development of tandem copper-catalysed arylation-cyclisation strategies: synthesis of biologically active compounds (DST-SERB)
• Jr. Manager, MSN R&D Centre Pvt. Ltd, 2025-, Hyderabad, Telangana, India