MEGHA GUPTA
Kolkata
Summary
A recent MTech graduate in Biotechnology with a strong academic foundation and a keen interest in teaching and research, seeking an Assistant Professor position. I possess a deep understanding of core biotechnology principles, including molecular biology, genetic engineering, bioprocessing, and microbiology, and am eager to contribute to the academic environment by fostering student engagement and promoting scientific inquiry.
Overview
4
4
years of professional experience
Work History
Research Intern- Khorana Scholarship
St.Jude Children's Research Hospital
06.2023 - 01.2024
- The primary aim of this research was to find out the impact of Integrator complex subunits on synthetic transcription factor mediated Frataxin expression using siRNA mediated gene silencing and pull down assays
- Performed mammalian cell culture techniques to seed, maintain FRDA diseased and healthy cell lines(fibroblast and B-lymphocytes) followed by synthetic compound treatment
- Conducted siRNA mediated gene silencing for all 14 subunits of Integrator complex and ChIP-qPCR for checking enrichment of selected subunits followed by data analysis using RT-qPCR, gene ontology and network studies
- Collaborated with lab members and other lab in other projects
- Conclusion: The study illustrated that some subunit of Integrator Complex play a significantly positive role in synthetic gene regulation process of FRDA while others play the negative role
Research Intern
CSIR- CFTRI
01.2022 - 06.2022
- The primary aim of this research was to study the effects of different drying and extraction methods on bioactives and pigment profile followed by product formulation of pigmented parts of Clitoria ternatea L
- Flowers
- Carried out different drying method and extraction with varied solvents for the floral part
- Conducted out antioxidant assays (DPPH, ABTS, and FRAP), bioactive analysis using assays (TFC and TPC) and various chromatographic and spectrophotometric techniques (UHPLC, HRMS), and pigment analysis using pH differential method and HPLC
- Analyzed and calculated the yield of each type of drying and extraction method separately for determining the optimum criteria
- Prepared two RTS-beverage and a spray-dried powder of the floral extract with maltodextrin as a carrier agent was prepared which can be later incorporated into other food model systems to impart the natural color
- Conclusion: The study successfully identified the best drying and extraction method for Clitoria Ternatea L., with the most nutrient retention and highest yield
Research Intern- MITACS Globalink Research Internship-2021
University of Saskatchewan
07.2021 - 10.2021
- This project aimed to analyze the role of three ferroptosis pathway genes namely Iron Accumulation Driver, Suppressor and Inhibitor on 12 types of cancer which can serve as a hallmark for cancer diagnosis
- Determined differentially expressed gene (DEGs) in all 12 types of Cancer and identified common upregulated gene related to ferroptosis pathway
- Analyzed the pairwise gene correlation pattern and generated a PPI network between the DEG and other human protein
- Conclusion: The study found correlated gene-pairs involved in ferroptosis which can act as hallmarks for all cancer types
Research Intern
Amity University
06.2020 - 01.2021
- This in-silico study aimed to identify inhibitory compounds targeting Mycobacterial copper transport protein
- Carried out homology Modeling for Mycobacterium membrane protein
- Screened chemical compound against McTb from 1500 small molecules of the Diverse-lib using MTiOpenScreen
- Performed ADMET studies and molecular docking for screened compound
- Collaborated with lab members and published the study in renowned international journal
- Conclusion: The study proposed these compounds as an effective candidate to reduce the growth of M
- Tuberculosis and may also assist present a novel therapeutic approach for Tuberculosis
Research Intern- Young Science Leader Program
Amity University
04.2020 - 11.2020
- This study aims to evaluate the inhibitory efficiency of the organic acids and phenolic compounds present in Brassica oleracea (Tronchuda Cabbage) against spike glycoprotein in SARS-CoV-2
- Identified novel phytomolecules from Brassica oleracea following lipinski's rule for this study and conducted protein-ligand docking studies
- Prepared the manuscript which is published in international peer journal
- Collaborated with bio-informaticians to perform molecular dynamics simulation
- Conclusion: The findings from molecular docking and MD simulation studies proposes two phyto-molecules from Tronchuda cabbage possess potential inhibitory capacity against spike glycoprotein trimer of SARS-CoV-2 and could be further taken up as lead targets for drug discovery
Education
MTech - Industrial Biotechnology
National Institute of Technology of Technology
01-2024
BTech - Biotechnology
Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science And Technology
01-2022
Class XII - AISSCE
Techno India Group Public School
Kolkata, India01-2018
Class X - AISSE
Techno India Group Public School
01-2016
Publications
- Dwivedi, M., Jose, S., Gupta, M., Devi, S. S., Raj, R., Kumar, D., Copper transporter protein (MctB) as a therapeutic target to elicit antimycobacterial activity against tuberculosis., Journal of Biomolecular Structure Dynamics, 1-15, 2023, https://doi.org/10.1080/07391102.2023.2226728
- Jose, S., Gupta, M., Sharma, U., Quintero-Saumeth, J., Dwivedi, M., Potential of phytocompounds from Brassica oleracea targeting S2-domain of SARS-CoV-2 spike glycoproteins: Structural and molecular insights., Journal of Molecular Structure, 1254, 132369, 2022, https://doi.org/10.1016/j.molstruc.2022.132369
Accomplishments
- Recipient of Khorana Program for Scholars 2023 Awardee.
- Qualified national entrance exam- Graduate Aptitude Test in Engineering (GATE 2022) with 612 all India rank.
- Gold medalist(2022), Biotechnology dept., Veltech University
- Recipient of Mitacs Globalink Research Internship 2021 Awardee.
- Received 'Best Paper' award for Presenting Technical Paper in International e-Conference sponsored by AICTE, New Delhi, Organised by St. Joseph College of Engineering in 2020.
- Presented Technical e-Poster in National e-Conference on 'Alternatives to Animal Testing' sponsored by AICTE, New Delhi, 2020.
- Received 2nd Prize for Project Display and Presentation in the State Level Project Expo Cum Contest - 'TECHYUGAM 2019'.
- Secured 2nd place in Code Debugging Contest in Vel Tech Science Fest 2019.
- Recipient of University Scholarship from Vel Tech RR and SR R&D Institute of Science and Technology in 2018.
Laboratory Skills
- Mammalian Cell Culture and Transfection
- Protein-based assays
- Molecular Biology and Genetic Engineering
- Bacterial Culture
- Bioanalytical Techniques
- Bio-Informatics, genomics and statistical analysis
- Programming and Computational Biology
Workshops And Certifications
- Online Workshop on Computer Aided Drug Design using BOVIA Discover Studio, 08/01/20, Deen Dayal Upadhyaya Gorakhpur University
- Data Science in Stratified Healthcare and Precision Medicine, 07/01/20, University of Edinburgh (Coursera)
- Getting Started with Python, 06/01/20, University of Michigan (Coursera)
- Drug Discovery, 07/01/20, University of California San Diego (Coursera)
- Synapses, Neurons and brains, 07/01/20, Hebrew University of Jerusalem (Coursera)
Positions Of Responsibility And Volunteer Experience
- Under Secretary General, Vel Tech Model United Nation (MUN), 10/01/19, 06/30/20, Plan and coordinate all special events for delegates, including opening and closing ceremonies, guest speakers and presentations, and the delegate social in MUN 2020.
- House Captain, Student's Council, 06/01/16, 01/31/18, Coordinate the events organised by Techno India Group Public School, Garia and maintain assemblies.
- Volunteer, Smile Foundation, Collected funds for underprivileged children, youth and women.
Languages
English
Advanced (C1)
Hindi
Upper intermediate (B2)
Bengali
Intermediate (B1)
Timeline
Research Intern- Khorana Scholarship
St.Jude Children's Research Hospital
06.2023 - 01.2024
Research Intern
CSIR- CFTRI
01.2022 - 06.2022
Research Intern- MITACS Globalink Research Internship-2021
University of Saskatchewan
07.2021 - 10.2021
Research Intern
Amity University
06.2020 - 01.2021
Research Intern- Young Science Leader Program
Amity University
04.2020 - 11.2020
MTech - Industrial Biotechnology
National Institute of Technology of Technology
BTech - Biotechnology
Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science And Technology
Class XII - AISSCE
Techno India Group Public School
Class X - AISSE
Techno India Group Public School
Similar Profiles
Rose PrinceRose Prince
Clinical Research Regulatory Coordinator at Le Bonheur Children's Hospital, Children's Foundation Research InstituteClinical Research Regulatory Coordinator at Le Bonheur Children's Hospital, Children's Foundation Research Institute
Joshua GarmonJoshua Garmon
Senior Advisor, Area Development at ALSAC St. Jude Children's Research HospitalSenior Advisor, Area Development at ALSAC St. Jude Children's Research Hospital
Sara AlmoazenSara Almoazen
Research Intern at St Jude Children's Research HospitalResearch Intern at St Jude Children's Research Hospital
ASWINI KUMAR SHARMAASWINI KUMAR SHARMA
Associate General Manager – Procurement at AMPIN Energy Transition Pvt. Ltd.Associate General Manager – Procurement at AMPIN Energy Transition Pvt. Ltd.
ANJELA BANERJEEANJELA BANERJEE
Legal Intern at Kolkata Municipal Corporation CourtLegal Intern at Kolkata Municipal Corporation Court