Mohan Gupta gvrk

Experienced and results-driven professional with an outstanding 17-year tenure in the CRO sector, renowned for fostering innovation and consistently delivering measurable success. A forward-thinking leader, adept at inspiring and steering high-performing teams to exceed organizational goals and establish benchmarks of excellence. Proficient in leveraging advanced research methodologies and thriving in dynamic, fast-paced environments. Strongly committed to a client-focused approach, combining strategic vision and operational expertise to optimize productivity and drive sustainable growth

• BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder, Li, J., Zhang, H., Mathur, A., Grandhi V. R. K. M. Gupta, Kamble, M., Cheruku, S., Bristow, L. J., Islam, I., Bronson, J. J., Olson, R. E., King, D., Thompson, L. A., Macor, J. E., ACS Med. Chem. Lett., 2018, 9, 472−477.
• Novel benzylated (pyrrolidin-2-one)/(imidazolidin-2-one) derivatives as potential anti-alzheimer’s agents: Synthesis and pharmacological investigations, M Gupta, M Ojha, D Yadav, S Pant, R Yadav, ACS Chemical Neuroscience 11 (18), 2849-2860.
• Novel substituted pyrimidine derivatives as potential anti-alzheimer’s agents: synthesis, biological, and molecular docking studies, S Pant, R Kumar K, P Rana, T Anthwal, SM Ali, M Gupta, M Chauhan, ACS Chemical Neuroscience 15 (4), 783-797.
• Design, synthesis, extra-precision docking, and molecular dynamics simulation studies of pyrrolidin-2-one derivatives as potential acetylcholinesterase inhibitors, M Gupta, A Kumar, C Prasun, MS Nair, SG Kini, D Yadav, S Nain Journal of Biomolecular Structure and Dynamics 41 (13), 6282-6294.
• Investigation, scaffold hopping of novel donepezil-based compounds as anti-Alzhiemer’s agents: synthesis, in-silico and pharmacological evaluations, M Gupta, S Pant, P Rana, A Kumar, C Prasun, MS Nair, S Paliwal, S Nain Scientific Reports 14 (1), 1687
• Neuroprotective effects of novel pyrrolidine-2-one derivatives on scopolamine-induced cognitive impairment in mice: Behavioral and biochemical analysis, S Pant, M Gupta, T Anthwal, M Chauhan, S Nain, Pharmacology Biochemistry and Behavior 229, 173602.
• A recent appraisal of small-organic molecules as anti-Alzheimer’s agents, M Gupta, A Kumar, M Ojha, S Kausar Khan, S Nain, Mini Reviews in Medicinal Chemistry 23 (8), 962-976.
• The memory ameliorating effects of novel N-benzyl pyridine-2-one derivatives on scopolamine-induced cognitive deficits in mice, S Pant, M Gupta, T Anthwal, M Chauhan, S Nain, Laboratory Animal Research 40 (1), 9.

• Handled all type of moisture sensitive reactions and reagents such as n-BuLi, DIBALH, LAH, MeLi, AlCl3 etc.
• Carried out various named reactions like: 1) Suzuki coupling, 2) Sonogashira coupling, 3) Stille coupling, 4) Mitsunobu reaction 5) Dess-Martin peridionane oxidation, 6) Swern oxidation, 7) Buchwald–Hartwig coupling 8) Heck reaction, 9) Ullmann coupling 10) Fridelcrafts alkylation 11) Grignard reactions 12) Minisi reaction.
• Handled various High Pressure & Hydrogenation reactions in Parr Shakers, Autoclaves, Tiny claves & mini claves.
• Acquired knowledge of various Chromatographic techniques such as prep-TLC, Prep-HPLC, Flash column chromatography using-Combiflash, Grace & Biotage machines via both Normal phase & reverse phase purifications etc.

• Builds a strong team by mentoring individuals, enhancing their skills, and fostering collaboration to boost project productivity.
• Maintains daily communication with team members, providing motivation through practical examples to address chemistry challenges and resolve conflicts effectively.
• Identifies talent and delegates responsibilities for tasks like chemistry updates, raw material procurement, and data analysis, ensuring accuracy and minimizing errors for client presentations.

• Combinatorial Chemistry Expertise: Managed library projects ranging from 150 to 3000 targets in both FTE and FFS models, employing diverse reactions such as Amidation, Reductive Amination, Suzuki, Buchwald, Sonogashira, Photo-Redox, and Urea formation.
• Project & Chemistry Diversity: Successfully executed synthesis projects involving PROTACs, Molecular Glues, Steroids, Diverse Heterocyclic Analogues, Pro-drug Motifs, and PEG-Linkers, showcasing a broad range of expertise.
• Problem-Solving & Analytical Skills: Collaborated with chemists daily to resolve complex chemistry challenges, developed innovative synthetic routes based on current literature, and demonstrated proficiency in identifying organic compounds using NMR and LCMS techniques. Consistently delivered precise documentation adhering to customer requirements in formats like JOC and patents.

• Father's Name: G.V RANGA MANNAR
• Date of Birth: 08/10/82
• Gender: Male
• Marital Status: Married