Summary
Overview
Work History
Education
Skills
Publications
Book Chapters
Technical Skills & Instrumentation
Timeline
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Musundi Wabuyele

Bioanalytical Scientist
Whitestown,IN

Summary

A seasoned scientist with 20+ years in pharmaceuticals, diagnostics, and biotech. Known for innovative work in analytical chemistry and bio-conjugation. Experienced in assay development, separation science, and automation. Published extensively and managed complex projects efficiently. Expert in analytical methods for small molecules, oral solids, and protein characterization. Strong communicator and leader, skilled in team collaboration to achieve scientific and business goals.

Overview

20
20
years of professional experience

Work History

Bioanalytical Senior Lead Scientist I

Labcorp Drug Development
Indianapolis, Indiana
04.2021 - Current
  • Developed and implemented bioassays using LCMS techniques for drug discovery and preclinical studies
  • Led scientific projects for bioanalysis of drugs, metabolites, biomarkers, and active endogenous compounds
  • Reviewed and approved validation methods and raw data, enhancing assay reliability
  • Collaborated with teams to ensure timely and quality results, improving client relationships and project outcomes

Bioanalytical Lead Scientist II

Labcorp Drug Development
Indianapolis, Indiana
07.2019 - 04.2021
  • Conducted technical research studies and provided scientific guidance within Bioanalytical Services
  • Developed protocols ensuring compliance with SOPs, GLP, GCP, quality agreements, and regulatory guidelines
  • Coordinated with method development and validation teams to review and approve methods
  • Enhanced research efficiency by streamlining laboratory processes and implementing new technologies.

Commercial Quality Control Manager II

Takeda Pharmaceuticals
Cambridge, MA
11.2017 - 06.2019
  • Managed quality control test laboratories for injectable, parenteral, and oral solid dose products
  • Supported release and stability testing, ensuring compliance with Health Authorities
  • Decreased turnaround time for quality control data review, improving efficiency and performance
  • Participated in regular management review meetings, providing updates on quality control performance and suggesting areas for improvement.

Principal Consultant

Independent Pharmaceutical Consultant
03.2016 - 06.2019
  • Developed and implemented bioanalytical technologies and methodologies for drug development processes
  • Provided technical and bioanalytical support and LC and MS instrumentation training
  • Reduced system installation costs by 75% for a start-up biotech company
  • Built strong relationships with clients, fostering long-term partnerships and repeat business.

Investigator / Principal Scientist

GlaxoSmithKline
Collegeville, Pennsylvania
08.2005 - 03.2016
  • Managed analytical chemistry laboratory operations, developing and validating methods for biomolecules
  • Improved throughput by incorporating UHPLC systems and innovative detection approaches
  • Supported early drug discovery efforts with high-throughput automation and SAR prediction tools
  • Collaborated effectively with colleagues across various departments, fostering a culture of open communication and teamwork.
  • Achieved successful project outcomes by leading cross-functional research teams and leveraging scientific expertise.

Education

Postdoctoral Studies -

Oak Ridge National Laboratory
Oak Ridge, TN

Ph.D. - Analytical Chemistry

Louisiana State University
Baton Rouge, LA

Bachelor of Science - Chemistry

The University of Nairobi
Nairobi, Kenya

Skills

  • Bioanalytical Methods

  • Chromatographic Separations

  • Capillary Electrophoresis

  • Spectroscopic Methods

  • Analysis of Oligonucleotides, Peptides, and Monoclonal Antibodies

  • Analytical Method Development, Validation, and Transfer

  • Mass Spectrometry

  • Data Interpretation and Analytics

  • Quantitative Structure-activity Relationship (QSAR) and Multivariate Modeling

  • Strong Communication and Leadership Skills

  • Data visualization

Publications

  • Plasmonics nanoprobes: detection of single-nucleotide polymorphisms in the breast cancer BRCA1 gene, Musundi B. Wabuyele, Fei Yan and Tuan Vo-Dinh, Analytical and Bioanalytical Chemistry, 2010, 398, 729-736
  • Antibody-Based SERS Diagnostics of Fhit Protein without Label, P. M. Kasili, M.B. Wabuyele, T. Vo-Dinh, Nanobiotechnology, 2006, 2, 29-35
  • Development of an Advanced Hyperspectral Imaging (HSI) System with Applications for Cancer Detection, Matthew E. Martin, Musundi B. Wabuyele, Kui Chen, Paul Kasili, Masoud Panjehpour, Mary Phan, Bergein Overholt, Glenn Cunningham, Dale Wilson, Robert C. DeNovo, Tuan Vo-Dinh, Annals of Biomedical Engineering, 2006, 34, 1061 – 1068
  • FRET-based protein-DNA binding assay for detection of active NF-kB for use in biosensors, Ambra Giannetti, Lorenzo Citti, Claudio Domenici, Lorena Tedeschi, Francesco Baldini, Musundi B. Wabuyele and Tuan Vo-Dinh, Sensors and Actuators B-Chemical, 2006, 113, 649-654
  • Surface-enhanced Raman scattering Detection of Chemical and Biological Agent Simulants, Fei Yan, Musundi B. Wabuyele, G. Griffin, Arpad A. Vass, and Tuan Vo-Dinh, IEEE-Sensors, 2005, 5, 665-670
  • An AOTF-based Dual-modality Hyperspectral Imaging system (DMHSI) Capable of Simultaneous Fluorescence and Reflectance Imaging, Matt E. Martin, Musundi Wabuyele, Masoud Panjehpour, Bergein Overholt, Robert DeNovo, Steve Kennel, Glenn Cunningham, Tuan Vo-Dinh, Med Eng Phys, 2005, 28, 149-155
  • Detection of Human Immunodeficiency Virus Type 1 (HIV-1) DNA Sequence Using SERS Molecular Sentinel Nanoprobes, Musundi B. Wabuyele and Tuan Vo-Dinh, Analytical Chemistry, 2005, 77, 7810-7815
  • Hyperspectral Surface-Enhanced Raman Imaging (SERI) of Labeled Silver Nanoparticles in Single Cells, Musundi Wabuyele, Fei Yan and Tuan Vo-Dinh, Rev. Sci. Instrum., 2005, 76, Art. No. 063710
  • Surface-Enhanced Raman Scattering for Medical Diagnostics and Biological Imaging, Tuan Vo-Dinh, Fei Yan, Musundi B. Wabuyele, J. Raman Spectrosco., 2005, 36, 640-647
  • Electrokinetically Synchronized Polymerase Chain Reaction Microchip Fabricated in Polycarbonate, Chen, J., Wabuyele, M., Chen, H., Patterson, D., Hupert, M., Shadpour, H., Nikitopoulos, D., and Soper, S.A, Anal. Chem., 2004, 77, 658-666
  • Hyperspectral Imaging System for In vivo Optical Diagnostics, Tuan Vo-Dinh, David L. Stokes, Musundi Wabuyele, Matt E. Martin, Joon Myong Song, Ramesh Jagannathan, Edward Michaud, Robert J. Lee, and Xiaogang Pan, IEEE Engineering in Medicine and Biology Magazine, 2004, July
  • Single-photon counting technology for single-molecule detection applications in biotechnology, Trottier, C., Davies, M., Dautet, H., Wabuyele, M., Soper, S.A., Kapanidis, A.N., Lacoste, T., Weiss, S., Pharmagenomics, 2004, 4, 25-34

Book Chapters

  • Nanoimaging of biomolecules using Near-field Scanning Optical microscopy, M. B. Wabuyele and T. Vo-Dinh, Nanotechnology in Biology and Medicine: Methods, Devices and Applications, T. Vo‐Dinh, CRC Press, FL, 2007, 12
  • Cellular imaging and analysis using SERS‐active nanoparticles, M. B. Wabuyele, F. Yan, and T. Vo‐Dinh, Nanotechnology in Biology and Medicine: Methods, Devices and Applications, T. Vo‐Dinh, CRC Press, FL, 2007, 28
  • Surface-Enhanced Raman Scattering for Biomedical Diagnostics and Molecular Imaging, Tuan Vo-Dinh, Fei Yan and Musundi B. Wabuyele, Topics in Applied Physics, 2006, 103, 409-426
  • Surface‐enhanced Raman scattering for biomedical diagnostics and molecular imaging, T. Vo‐Dinh, F. Yan, and M. B. Wabuyele, Surface‐enhanced Raman Scattering ‐ Physics and Applications, K. Kneipp, M. Moskovits, H. Kneipp, 2006, 103, 409‐427
  • Nanoprobes and nanobiosensors for monitoring and imaging individual living cells, Tuan Vo-Dinh, Paul Kasili, Musundi Wabuyele, Nanomedicine: Nanotechnology, Biology, and Medicine, 2006, 2, 1, 22 – 30
  • Methods in Molecular Biology: Protein nanotechnology, Tuan Vo-Dinh, Near-field scanning optical microscopy for bioanalysis at nanometer resolution, Musundi B. Wabuyele, Mustafa Culha Guy D. Griffin, Pierre Viallet and Tuan Vo-Dinh, 2004, 437-452, Humana Press, NJ
  • Single molecule detection in solution, Christoph Zander, Jörg Enderlein, and Richard A. Keller, Single molecule detection in the Near-infrared, Steven A. Soper, Musundi Wabuyele, Clyde V. Owens and Robert P. Hammer, 2002, 323-362, Wiley-VCH publishers, Berlin

Technical Skills & Instrumentation

Renishaw Raman Microscope | Atomic Force Microscope | Near-field Scanning Optical Microscope | Fourier-transform Infrared Spectroscopy | UV-Vis Spectroscopy | Gas Chromatography-Mass Spectrometry | RapidFire 300/MS/MS | LC-MS/MS | HPLC/UPLC | Biomek Fx | CLND Antek System | XRPD | NMR | Biacore S51 | Dionex Corona CAD | ELSD | Microsoft Office | ACD Labs | Open Labs Chemstation | Empower | Masslynx | Spotfire | Statistica | Origin | JMP| Analyst | Watson-LIMS Software | Nautilus  | Veeva Vault

Timeline

Bioanalytical Senior Lead Scientist I

Labcorp Drug Development
04.2021 - Current

Bioanalytical Lead Scientist II

Labcorp Drug Development
07.2019 - 04.2021

Commercial Quality Control Manager II

Takeda Pharmaceuticals
11.2017 - 06.2019

Principal Consultant

Independent Pharmaceutical Consultant
03.2016 - 06.2019

Investigator / Principal Scientist

GlaxoSmithKline
08.2005 - 03.2016

Postdoctoral Studies -

Oak Ridge National Laboratory

Ph.D. - Analytical Chemistry

Louisiana State University

Bachelor of Science - Chemistry

The University of Nairobi
Musundi WabuyeleBioanalytical Scientist