COMPOUND DISCOVERER
Sidharth Nagamalli
BIOANALYTICAL SCIENTIST
Hyderabad,Telangana
Summary
Detail-oriented Analytical Scientist and PhD candidate specializing in LC-MS/MS bioanalysis, HRMS metabolomics, and pharmacokinetics. Developed and optimized targeted and untargeted metabolomics workflows using advanced mass spectrometry platforms. Expertise includes bioanalytical method development, drug metabolism studies, sample preparation, and pharmacokinetic analysis across various biological matrices.
Overview
7
7
years of professional experience
1
1
Language
Work History
Research Scholar
NIPER Hyderabad
01.2021 - Current
- Developed LC-MS/MS and HRMS workflows for pharmacokinetic and metabolomics studies.
- Performed targeted and untargeted metabolomics analysis in plasma, urine, feces, and MCF-7 cell systems.
- Conducted CYP2D6 inhibition and plasma/metabolic stability studies to assess drug interactions and safety profiles.
- Developed quantitative bioanalytical methods for tamoxifen and its metabolites.
- Operated Orbitrap, QTOF, and triple quadrupole platforms to generate reliable data for pharmacokinetic analyses.
- Characterized formulations using DSC, PXRD, ATR-IR, dissolution, and gut sac permeation studies to evaluate drug release and absorption.
- Conducted data analysis and interpretation for pharmacokinetic and metabolomics studies.
Project Assistant
NIPER-Guwahati
01.2021 - 07.2021
- Developed and validated analytical and bioanalytical methods to ensure reliability and accuracy in research.
- Prepared bioanalytical samples for quantification of NCEs and phytoconstituents using UPLC, contributing to data integrity.
- Designed and implemented pharmacokinetic studies in rodent models to support drug development processes.
Research Associate
Aten Porus Life Sciences
06.2019 - 06.2020
- Developed and optimized HPLC and LC-MS analytical methods to enhance characterization of NCE molecules.
- Performed chromatographic optimization and method troubleshooting to ensure reliable quantitative analysis.
- Performed chromatographic optimization, method troubleshooting, and quantitative analysis.
- Assisted in analytical documentation and interpretation of data to support accurate reporting.
Education
Ph.D. - Pharmaceutical Analysis
NIPER
Hyderabad01-2026
M.S. (Pharm) - Pharmaceutical Analysis
NIPER
Ahmedabad01-2019
No Degree -
ST.ANNE'S HIGH SCHOOL
Vijayawada, India 04.2001 -
Skills
- Bioanalytical method development and validation
- HPLC and UPLC method development
- Mass spectrometry
- Targeted and untargeted metabolomics
- Pharmacokinetic and drug-drug interaction studies
- CYP inhibition assays
- Sample preparation techniques
- Analytical chemistry
- Analytical technique application
- Statistical analysis
- Software: Compound Discoverer, MassHunter, Xcalibur, GraphPad Prism
- Formulation assessment
Accomplishments
- NIPER-JEE PhD 2020 – AIR 11
- NIPER-JEE MS 2017 – AIR 128
- GPAT 2017 – AIR 1554
Software
MASS HUNTER
MS-EXCEL
GRAPH PAD PRISM
ORIGIN
METABOANALYST
MzMINE
Interests
SCIENCE & TECHNOLOGY
SPORTS
ANIME
SELECTED PUBLICATIONS
- Coamorphous system of tamoxifen and curcumin: Tailored release, synergism and enhanced pharmacological outcomes to combat breast cancer – Journal of Drug Delivery Science and Technology (2026)
- Mitochondria-Targeting SIRT3 Activator Effectively Controls Bleomycin-Induced Pulmonary Fibrosis – Biofactors (2025)
- Coamorphous systems of rebamipide – International Journal of Pharmaceutics (2024)
- Synthon Approach in Crystal Engineering – Molecular Pharmaceutics (2024)
- Paradigm Shift in Sample Preparation and Bioanalytical Approaches – Analytical Sciences (2019)
Timeline
Project Assistant
NIPER-Guwahati
01.2021 - 07.2021
Research Scholar
NIPER Hyderabad
01.2021 - Current
Research Associate
Aten Porus Life Sciences
06.2019 - 06.2020
No Degree -
ST.ANNE'S HIGH SCHOOL
04.2001 -
M.S. (Pharm) - Pharmaceutical Analysis
NIPER
Ph.D. - Pharmaceutical Analysis
NIPER