NAGENDRA PRASAD K
Senior Scientist Level I – Precision Oncology & Computational Biology
Bangalore
Summary
Senior Scientist with 9+ years of expertise in developing systems biology models and building gene regulatory networks. Proven ability to integrate diverse data sources to uncover predictive novel biomarkers and enhance therapeutic efficacy.
Overview
2
2
Certifications
9
9
years of professional experience
Work History
Senior Scientist Level I
CELLWORKS RESEARCH INDIA PRIVATE LIMITED
07.2025 - Current
- Curated structured datasets for 4 experimental preclinical compounds with limited literature evidence to support computational biology, statistical learning, and machine learning-driven novel biomarker discovery and therapeutic target identification.
- Developing systems biology–based mathematical models by integrating molecular signaling networks and biological interactions to predict therapeutic response across patient-derived genomic profiles and cancer cell lines.
- Collaborated with cross-functional teams to design innovative research projects for experimental compounds with limited data published from literature.
- Enhanced team performance by providing expert technical training on new methodologies.
Scientist Level III
CELLWORKS RESEARCH INDIA PRIVATE LIMITED
07.2024 - 07.2025
- Assessing genomics of patients to determine personalized drug regimens suited for unique profiles.
- Analyzing genomic data from patient cohorts using in-house database.
- Training a mathematical model by establishing protein network using enzyme kinetic equations to predict drugs efficacy on a genomic profile.
- Point of contact from R&D wing to provide inputs for automation and script development.
Scientist Level II
CELLWORKS RESEARCH INDIA PRIVATE LIMITED
07.2023 - 07.2024
- Research on 10+ immuno-onco drugs to understand their advantage over chemotherapy
- Predicting outcome of combinations of drugs on prospective and
retrospective studies to build confusion matrix to determine the
accuracy of the model - Conducted experiments in insilico environment to validate hypotheses in unique combinations
Scientist Level 1
CELLWORKS RESEARCH INDIA PRIVATE LIMITED
07.2019 - 07.2023
- Leveraging pharmacokinetic (PK), pharmacodynamic (PD) of drugs, genomic, and mechanistic insights to investigate drug sensitivity and resistance mechanisms, systematically documenting literature-derived biological evidence for mathematical modeling
- Evaluating scientific literature to reconstruct 40+ drug regulatory networks by integrating direct and indirect molecular interactions to understand disease biology, predict therapeutic response, and identify clinically relevant biomarkers
- Combine clinical trial outcomes with mechanistic biological evidence to uncover molecular drivers of therapeutic efficacy resistance mechanisms and predictive biomarker hypotheses.
Associate Scientist
CELLWORKS RESEARCH INDIA PRIVATE LIMITED
08.2017 - 07.2019
- Studied direct and indirect protein–protein interaction (PPI) networks to understand molecular relationships and functional connectivity based on Enzyme kinetics.
- Examined signaling pathways and pathway interactions to reveal biological mechanisms driving disease on a broader scale.
- Evaluated the effects of gene/protein overexpression and knockdown on downstream biomarkers and cellular phenotypes.
- Assessed the impact of protein expression changes on drug efficacy and therapeutic response through literature-based analysis.
Education
Bachelor of Engineering - Biotechnology
Dayananda Sagar College of Engineering | Affiliated To VTU
Bengaluru, India 04.2001 -
Skills
Computational Biology & Bioinformatics
Multi-omics Data Integration
Gene Set Enrichment Analysis (GSEA)
Weighted Gene Co-expression Network Analysis (WGCNA)
Machine Learning & Statistical Analysis
Supervised and Unsupervised learning
Spearman Correlation
Mann–Whitney U Test
Fisher's Exact Test
Multiple Testing Correction (Benjamini–Hochberg FDR)
Scientific Literature Interpretation
Cancer genomic analysis
Clinical trial analysis
Programming & Data Analysis
Python
SQL
Professional Skills
Scientific Writing
Technical Presentations
Training & Mentoring
www.linkedin.com/in/nagendra-prasad-k-b07561ab
Github
https://github.com/nagendraprasad94-ops/Gene-Set-Enrichment-Analysis/tree/main
Accomplishments
Publication at American society of clinical oncology: Cellworks Omics Biology Modeling (CBM) to predict therapy response and identifies novel biomarkers for carboplatin/cisplatin along with pemetrexed in NSCLC patients.
Certification
Python
Additional Information
Therapeutic Expertise
Microtubule-Targeting Agents : Paclitaxel, Docetaxel, Vincristine, Vinblastine, Eribulin (microtubule dynamics, mitotic arrest, resistance mechanisms).
DNA Damaging agents : 5-Fluorouracil (5-FU), Capecitabine, Trifluridine, Temozolomide, Procarbazine, Dacarbazine, Olaparib, Niraparib (HR, MMR, BER, NER, PARP trapping, synthetic lethality).
Targeted Small Molecule Inhibitors : EGFR inhibitors (Gefitinib, Erlotinib, Afatinib, Osimertinib); MEK inhibitors (Trametinib, Cobimetinib, Binimetinib, Selumetinib); AKT inhibitors (Capivasertib).
Targeted Antibody Therapeutics : Monoclonal antibodies (Pertuzumab); Antibody–Drug Conjugates (Brentuximab Vedotin);
Immune Checkpoint Inhibitors: Anti-PD-1 : Nivolumab, Pembrolizumab. Anti-PD-L1 : Atezolizumab, Durvalumab, Avelumab, Anti-CTLA-4: Ipilimumab, Tremelimumab
Timeline
Machine learning
05-2026
Senior Scientist Level I
CELLWORKS RESEARCH INDIA PRIVATE LIMITED
07.2025 - Current
Scientist Level III
CELLWORKS RESEARCH INDIA PRIVATE LIMITED
07.2024 - 07.2025
Scientist Level II
CELLWORKS RESEARCH INDIA PRIVATE LIMITED
07.2023 - 07.2024
Python
10-2022
Scientist Level 1
CELLWORKS RESEARCH INDIA PRIVATE LIMITED
07.2019 - 07.2023
Associate Scientist
CELLWORKS RESEARCH INDIA PRIVATE LIMITED
08.2017 - 07.2019
Bachelor of Engineering - Biotechnology
Dayananda Sagar College of Engineering | Affiliated To VTU
04.2001 -