Nagesh Dhanaji Chavan
Research Associate
Bangalore
Summary
- Proficient in conducting laboratory and field experiments while informing new hires on research methods and data collection procedures. Hardworking and driven with superior organizational and analytical skills combined with unparalleled dedication to research excellence. Skilled in conceptualization, design and implementation of projects.
Overview
5
5
years of professional experience
3
3
Languages
Work History
Research Associate
Sigma Aldrich (Merck) Bangalore
06.2025 - Current
- Planning experiments and developments
- Developing cost-effective synthesis of compounds from miligram to gram scale.
- Reduce the impurities (organic, inorganic, and solvents) in synthetic compounds as per requirement.
- Establishing specifications for key starting materials and intermediates.
- Synthesis, Analysis, Purification, Isolation, and Characterization of various compounds.
- Good knowledge of purification and crystallization of intermediates.
- Conducted micro and process scale experiments in laboratory environment process for product development purposes.
- Collaborated with multidisciplinary teams to drive project success and achieve objectives.
- Helped team meet regulatory requirements by coordinating documentation and filings.
- Analyzed results using analytical software and created reports.
- Provided support and guidance to junior lab staff.
- Assisted scientists by collecting and organizing laboratory data.
- Collaborated with researchers and scientists to design and execute experiments.
Research Associate
Aragen Life Sciences Hyderabad
05.2021 - 07.2022
- Expertise in many areas like screening, design, evaluation of synthetic routes, process development, optimization, and Structural conformation by NMR (1H NMR & 13C NMR), Mass (LC-MS, GC-MS, ESI MS, etc.), FT-IR and HPLC are part of regular work.
- Looking care of scale-up activities for delivery on time with quality standards.
- Expertise in the preparation of Protected Amino Acids (N-Me, Fmoc, Boc, and CBZ).
- Handling of metals such as palladium, iron, coupling reagents (HOBt.H2O, DCC, EDC.HCl, HBTU, HATU etc.
- Experience in handling air sensitive reaction like Suzuki, Heck, Sonogashira etc.
- Experience in handling pyrophoric and hazardous reagents such as LiAlH4, Pd/C, BH3-THF, RMgX, n-BuLi, LDA, preparation of Grignard, etc.
- Handling various types of columns like Gravity Column, Flash Column, Combi-Flash.
- An up-to-date overview of literature and scientific journals.
- Literature Survey like as Sci-Finder Search, Reaxys Search etc.
Education
Ph.D. - Chemistry
08.2025
- Thesis Submitted
- Department: School of Advanced Sciences
- Dissertation Title: “SYNTHESIS, BIOLOGICAL AND PHOTOPHYSICAL PROPERTIES OF 3-ACETYL/CARBETHOXY-6 AMINO-2-METHYL-4-PHENYL QUINOLINE BASED HETEROCYCLES WITH DFT CALCULATIONS
- Advisor: Prof. Dr. V Vijayakumar
Master of Science (M. Sc.,) - Chemistry
06.2020
- Dissertation Title: “Synthesis and Biological study of 5-hydroxy-1,3-diphenyl-2,3-dihydro-1H-pyrazole-4-carbonitrile and their derivatives.”
- Advisor: Prof. Dr. Shital Jagtap
- GPA: 68.23%
Bachelor of Science (B. Sc.,) - Chemistry
04.2017
GPA: 62.86%
Skills
Organic Synthesis of Intermediates & Heterocycles
Process Development Chemistry
Reaction Optimization & Troubleshooting
Scale-Up Chemistry (mg to gram/bulk scale)
Impurity Profiling & Control
Purification & Crystallization Techniques
Catalysis & Cross-Coupling Reactions (Suzuki, Heck, Sonogashira)
Handling Air-Sensitive & Hazardous Reagents
NMR Spectroscopy (¹H & ¹³C)
HPLC Method Use & Purity Analysis
LC-MS / GC-MS Analysis
FT-IR & UV-Visible Spectroscopy
Reaction Monitoring & Batch Analysis
CDMO R&D Environment Experience
Cost-Effective Route Development
Quality-Focused Synthesis & Delivery Timelines
Technical Documentation & Reporting
Literature Review (SciFinder, Reaxys)
DFT & Computational Chemistry (Supportive Role)
Scientific Writing & Data Interpretation
Research planning
Documentation skills
Timeline
Research Associate - Sigma Aldrich (Merck) Bangalore
06.2025 - Current
Research Associate - Aragen Life Sciences Hyderabad
05.2021 - 07.2022
Annasaheb Magar College Pune - Master of Science (M. Sc.,), Chemistry
Adarsh Senior College Omerga - Bachelor of Science (B. Sc.,), Chemistry
Vellore Institute of Technology - Ph.D., Chemistry
Languages
Hindi
Bilingual or Proficient (C2)
English
Advanced (C1)
Marathi
Bilingual or Proficient (C2)
Publications
- Chavan, N. D. Vijayakumar, V. (2024), ‘Synthesis, DFT studies on a series of tunable quinoline derivatives’, RSC advances 14(29), 21089-21101.
- Chavan, N. D, Vijayakumar,V. (2025), ‘Palladium catalyzed carbon-carbon bond formation on tunable quinolines with DFT study’, Journal of Molecular Structure 1321, 139739.
- Chavan, N. D., Sarveswari, S., Vijayakumar, V. (2025), ‘Synthesis of novel sulphonamide derivatives from tunable quinolines with computational studies. Scientific Reports 15(1), 10972.
- Chavan, N. D., Shanmugavel, B., Tamboli, Y., Vijayakumar, V. (2025), ‘A Comprehensive Investigation of Diverse Synthetic Methodologies for Constructing Quinoline Frameworks: A Critical Overview’, ChemistrySelect 10(10), e202500851.
- Chavan N. D, Sarveswari S, Vijayakumar V. (2025), ‘Quinoline derivatives' biological interest for anti-malarial and anti-cancer activities: an overview, RSC advances.15(37), 30576-604.
- Sharma A, Tamboli Q. Y., Chavan N. D., Jyothish Kumar L, Sarveswari S, Zakde K. R., Vijayakumar V. (2025), ‘Synthesis of Quinoline-Dihydropyrimidines: A Synergistic Green Approach Using Magnetically Recoverable Catalysts in Aqueous Medium. Catalysis Letters, 155(6), 195.
Handled instruments and techniques
- Instrumental Techniques: Photoluminescence (PL), UV-Visible Spectroscopy, FT-IR.
- Software Exposures: MS Office, Gaussian View 09, Ultra Chemdraw, Mesternova, Topspin, Origin Pro 8.1, Olex2 (Single Crystal Analysis), AutoDock 4.
Awards/Scholarships
Raman Research award for research article by VIT-Vellore for the month of August 2024., Raman Research award for research article by VIT-Vellore for the month of December 2024., Dr. APJ ABDUL KALAM Award for review article by VIT-Vellore for the month of March 2025.
Declaration
I hereby declare that the details furnished above are true to the best of my knowledge and belief.
Teaching Experience
- Assistance in Laboratory Courses:
- Courses Taught: Engineering Chemistry Laboratory (Undergraduate - B.Tech First Year) and M.Sc. Chemistry Laboratory Experiments
- Duration: 6 months per course
- Level: Undergraduate (B. Tech First Year) and Postgraduate (M. Sc)
- Experience: August 2022 – June 2025
Conferences/Workshops organized
- Participate In International Conference on Organic and Medicinal Chemistry (ICOMC-2023) Organized by National Institute of Technology Warangal, India.
- Participated International conference on “EMERGING TRENDS IN MATERIAL SCIENCE 2024 (ETMS-24) held at Sona College Salem Tamil Nadu, India.
- Participated and presented a poster in Chemistry and Catalysis workshop held at Department of Chemistry, School of Advanced Sciences, VIT Vellore, Tamil Nadu, India.
Publications
- Chavan, N. D. Vijayakumar, V. (2024), ‘Synthesis, DFT studies on a series of tunable quinoline derivatives’, RSC advances 14(29), 21089-21101.
- Chavan, N. D, Vijayakumar,V. (2025), ‘Palladium catalyzed carbon-carbon bond formation on tunable quinolines with DFT study’, Journal of Molecular Structure 1321, 139739.
- Chavan, N. D., Sarveswari, S., Vijayakumar, V. (2025), ‘Synthesis of novel sulphonamide derivatives from tunable quinolines with computational studies. Scientific Reports 15(1), 10972.
- Chavan, N. D., Shanmugavel, B., Tamboli, Y., Vijayakumar, V. (2025), ‘A Comprehensive Investigation of Diverse Synthetic Methodologies for Constructing Quinoline Frameworks: A Critical Overview’, ChemistrySelect 10(10), e202500851.
- Chavan N. D, Sarveswari S, Vijayakumar V. (2025), ‘Quinoline derivatives' biological interest for anti-malarial and anti-cancer activities: an overview, RSC advances.15(37), 30576-604.
- Sharma A, Tamboli Q. Y., Chavan N. D., Jyothish Kumar L, Sarveswari S, Zakde K. R., Vijayakumar V. (2025), ‘Synthesis of Quinoline-Dihydropyrimidines: A Synergistic Green Approach Using Magnetically Recoverable Catalysts in Aqueous Medium. Catalysis Letters, 155(6), 195.
Handled instruments and techniques
- Instrumental Techniques: Photoluminescence (PL), UV-Visible Spectroscopy, FT-IR.
- Software Exposures: MS Office, Gaussian View 09, Ultra Chemdraw, Mesternova, Topspin, Origin Pro 8.1, Olex2 (Single Crystal Analysis), AutoDock 4.
Awards/Scholarships
Raman Research award for research article by VIT-Vellore for the month of August 2024., Raman Research award for research article by VIT-Vellore for the month of December 2024., Dr. APJ ABDUL KALAM Award for review article by VIT-Vellore for the month of March 2025.
Declaration
I hereby declare that the details furnished above are true to the best of my knowledge and belief.