PRATIBHA KUMARI

Dynamic leader in biopharmaceutical development with 5 years of experience specializing in therapeutic antibodies downstream process development, technology transfer, and process characterization. Offers over a decade of research proficiency in protein expression, purification, and structural analysis of complex proteins and nanoparticles, complemented by 7 peer-reviewed publications. Known for strong leadership and collaboration skills that enhance team performance in academic and R&D settings. Committed to leveraging extensive expertise to drive innovative advancements in biopharmaceutical solutions.

• Kumari, P, Eichmann, C & Riek R. High-density lipoprotein-like particle formation of Synuclein variants. FEBS Lett. 591, 304-311 (2017).
• Kumari, P, Frey L, Sobol A, Lakomek NA, Riek R. 15 N transverse relaxation measurements for the characterization of µs-ms dynamics are deteriorated by the deuterium isotope effect on15 N resulting from solvent exchange. Journal of biomolecular NMR. 1;72(3-4):125-37 (2018).
• Kumari P., Ghosh D., Vanas A., Fleischmann Y., Wiegand Thomas., Jeschke G., Riek R. and Eichmann C. Structural Insights into α-Synuclein Monomer-Fibril Interactions. PNAS, 118, 10 2012171118, (2021).
• Burmann, B.M., Gerez, J.A., Matečko-Burmann, I., Campioni, S., Kumari, P et al., Regulation of α-synuclein by chaperones in mammalian cells. Nature, 577(7788), pp.127-132. (2020).
• Guerrero-Ferreira, R., Taylor, N.M., Arteni, A.A., Kumari, P et al., Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8 (2019).
• Kumar H, Singh J, Kumari P, Udgaonkar JB. Modulation of the extent of structural heterogeneity in α-synuclein fibrils by the small molecule thioflavin T. JBC, 16891-903 (2017).
• Ashkinadze D, Kadavath H, Pokharna A, Chi CN, Friedmann M, Strotz D, Kumari P, Minges M, Cadalbert R, Königl S, Güntert P. Atomic resolution protein allostery from the multi-state structure of a PDZ domain. Nature Communications (2022).