Prayasee Baruah

Post-doctoral researcher with proven track record in conducting high-impact research and contributing to scientific advancements. Expertise in data analysis, literature review, and experimental design. Known for delivering results and reliable in achieving project goals.

• 05/01/24, present, Postdoctoral researcher, IIT Hyderabad, Dr. Surajit Maity, Fluorescence and laser spectroscopy, Development of an indigenous spectrometer for probing triplet excited states of intermediates formed in various biochemical reactions.
• 03/01/22, 02/29/24, Research Associate, JNCASR, Bengaluru, Prof. Thimmaiah Govindaraju, Biophysical Chemistry, Study of ferroptosis and its relevance in and relation to Alzheimer’s disease based on the amyloid-beta, tau fibrillation and oxidative stress pathways as well as devising schemes and assays for better understanding of ferroptosis; design of dual therapeutics for Alzheimer’s and Fe-induced Alzheimer’s disease along with study of liquid-liquid phase separation of tau and its relevance to metal toxicity and neurodegeneration; post-translational modification modulators in amyloid proteins.
• 10/01/16, 12/31/21, PhD, NEHU, Shillong, Prof. Sivaprasad Mitra, Spectroscopic studies on the modulatory effect of nano-biointerfaces on some selected neurodegenerative and mitochondrial enzyme activities, Photophysical/Biophysical Chemistry, Photophysical studies on protein-ligand and protein-nanoparticle interaction studies using in vitro techniques viz UV-vis, steady-state fluorescence; enzyme kinetics (chiefly acetylcholinesterase and citrate synthase); inhibition for development and re-purposing of drugs in neurodegenerative (Alzheimer’s disease), diabetes and mitochondrial disorders.

• AWSAR best popular science story award, 2020, Department of Science and Technology, India, Government of India (DST), Ph.D
• Best poster award, Photophysical Behavior of Coumarin Derivatives and Their Inhibitory Effect on AChE Activity, Trombay Symposium on Radiation & Photochemistry (TSRP-2018), BARC, Mumbai, 01/03/18 to 01/07/18
• Obtained 20th state rank in matriculation (HSLC) in Assam, 2009
• Work of first-authored publication featured in various leading media outlets, Chem. Sci, 14 (2023) 9427–9438
• Chem. Sci, 14 (2023) 9427–9438 was one of the most popular articles in Chemical Biology in 2022
• J. Pept. Sci, 29 (2022) 3465-3471 was featured in the top downloaded article list in 2022
• Materials Horizons, 11 (2024) 3082-3089 was selected as a HOT paper of 2024

1. P. Baruah, D. Padhi, H. Moorthy, M. Ramesh, T. Govindaraju, Navigating the dichotomy of reactive oxygen, nitrogen, and sulfur species: detection strategies and therapeutic interventions, RSC Chemical Biology, 2025, Advance Article.

2. H. Moorthy, M. Ramesh, D. Padhi, P. Baruah, T. Govindaraju, Polycatechols inhibit ferroptosis and modulate tau liquid–liquid phase separation to mitigate Alzheimer's disease, Materials Horizons, 11 (2024) 3082-3089.

3. D. Padhi, P. Baruah, M. Ramesh, H. Moorthy, T. Govindaraju, Hybrid molecules synergistically mitigate ferroptosis and amyloid-associated toxicities in Alzheimer's disease, Redox Biology, 71 (2024) 11024-11029.

4. P. Baruah, H. Moorthy, R. Madhu, D. Padhi, T. Govindaraju, A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer’s disease, Chemical Science, 14 (2023) 9427–9438.

5. R. Madhu. C. Balachandra, P. Baruah, T. Govindaraju, Cyclic dipeptide‐based small molecules modulate zinc‐mediated liquid‐liquid phase separation of tau, Journal of Peptide Science, 29 (2022) 3465-3471.

6. A. Bhatta, P. Baruah, P. T. Phanrang, G. Basumatary, G. Bez, S. Mitra, Modulated photophysical properties and sequestration of potent anti- acetylcholinesterase active coumarinyl dyes in human serum albumin, Dyes and Pigments, 208 (2022) 110871

7. P. Baruah, D. Ray, I. Konthoujam, A. Das, S. Chakraborty, K. Aguan, S.Mitra, Therapeutic Oppurtunities of Surface-Active Ionic Liquids: A Case Study on Acetylcholinesterase, Citrate Synthase and HeLa cell lines, New Journal of Chemistry, 46 (2022) 20419-20432

8. P. T. Phanrang, P. Baruah, A. Chandra, S. Mitra, Auxiliary Therapeutic Role of Cholinergic Agents: Mechanistic Insights into the Antioxidant Behaviour of AD Drugs towards Reversing DNA Oxidative Stress, The Journal of Physical Chemistry A, 126 (2022) 546–556.

9. P. Baruah, D. Paul, S. Mitra, Elevated Fibrinogen Level Reduces Therapeutic Efficiency of AD Drugs: Biophysical Insights on the Interaction of FDA Approved Cholinesterase Inhibitors with Human Fibrinogen, The Journal of Physical Chemistry B, 126 (2022) 30-43.

10. P. Baruah, P. T. Phanrang, I. Konthoujam, K. Aguan, S. Mitra, Cholinergic drugs bind at the minor groove and reverse induced oxidative stress of calf thymus DNA: a a new perspective towards an unexplored therapeutic efficacy, New Journal of Chemistry, 45 (2021) 13925-13933.

11. P. Baruah, A. Das, D. Paul, S. Chakrabarty, K. Aguan, S. Mitra, Sulfonylurea Class of Antidiabetic Drugs Inhibit Acetylcholinesterase Activity: Unexplored Auxiliary Pharmacological Benefit toward Alzheimer’s Disease, ACS Pharmacology & Translational Science, 4 (2021) 193-205.

12. P. Baruah, S. O. Yesylevskyy, K. Aguan, S. Mitra, Modulation of enzyme activity at nano-bio interface: A case study with acetylcholinesterase and citrate synthase adsorbed on colloidal metal nanoparticles, Journal of Molecular Liquids, 325 (2021) 115201.

13. P. Baruah, I. R. Singh, S. Mitra, Multi-spectroscopic investigation on the contradictory relevance of metal nanoparticles in pharmacological milieu of protein glycation and cholinergic inhibition, The NEHU Journal, XVIII (2020) 82- 98.

14. M. A. Rohman, P. Baruah, A. Bhatta, S. Mitra, Deciphering the interactions of substituted chromones possessing acetylcholinesterase inhibition activity in human serum albumin matrix, Journal of Molecular Liquids, 290 (2019) 111210.

15. M. A. Rohman, P. Baruah, S. O. Yesylevskyy, S. Mitra, Specific solvent effect on the photophysical behavior of substituted chromones: A combined fluorescence, DFT and MD study, Chemical Physics, 517 (2019) 67-79.

16. M. A. Rohman, P. Baruah, D. Bhattacharjee, B. Myrboh, S. Mitra, Fluorescence solvatochromism and modulated anticholinergic activity of novel coumarin compounds sequestered in human serum albumin nanocavities, New Journal of Chemistry, 43 (2019), 18713-18725.

17. P. Baruah, M. A. Rohman, S. O. Yesylevskyy, S. Mitra, Therapeutic potency of substituted chromones as Alzheimer's drug: Elucidation of acetylcholinesterase inhibitory activity through spectroscopic and molecular modelling investigation, Bioimpacts, 9 (2019) 79-88.

18. P. Baruah, G. Basumatary, S. O. Yesylevskyy, K. Aguan, G. Bez, S. Mitra, Novel coumarin derivatives as potent acetylcholinesterase inhibitors: insight into efficacy, mode and site of inhibition, Journal of Biomolecular Structure and Dynamics, 37 (2019) 1750-1765.

• N. S. Moyon, I. R. Singh, P. Baruah, M. A. Rohman, S. Mitra, Application of luminol as solvatochromic probe and fluorescent biomarker for heterogenous media, Advances In Chemistry Research, 2019, Nova Science Publishers, New York, United States
• P. Baruah, M. M. Islam, S. Mitra, Efficiency and modulation of anti-acetylcholinesterase Activity: An in-vitro study on selected FDA approved Alzheimer drugs, Advances in Health and Disease, 2020, Nova Science Publishers, New York, United States