Premkumar Sakthivel

M.Sc. Biochemistry graduate combining six months of in vivo zebrafish research with hands-on clinical laboratory experience. Skilled in OECD-guided experimental design, biochemical assays, histological staining, and Python-based computational drug design (CADD). Navigating hearing and vision disabilities since 2021 has strengthened my adaptability and strategic problem-solving. I am a highly motivated, results-oriented professional committed to leveraging my hands-on skills to deliver impactful scientific solutions in fast-paced environments.

Investigation of Protective Effects of Naringin Against DSS-Induced Gut Inflammation in Zebrafish,   2025-12|2026-04

PSG College of Arts & Science,  Guide: Dr. Sakthivel K M

• Established DSS-induced colitis model in zebrafish larvae; evaluated Naringin across multiple concentrations (OECD-guided),
• Performed histological staining: Acridine Orange, Alcian Blue, Neutral Red, DCFH-DA, Ran biochemical assay panel: NO, LPO, SOD, CAT, GSH,
• Results showed dose-dependent reduction in oxidative stress and intestinal inflammation

Targeted Molecular Docking of Flavonoids Against Glutathione Reductase (3GRS),  2026-04

• Curated a library of IBD-relevant flavonoids: Naringin, Naringenin, Quercetin, Kaempferol, Luteolin,
• Prepared protein (OpenBabel) and ligands (RDKit); docked at Cys58 & Cys63 using AutoDock Vina,
• Built complete Python-based pipeline in Google Colab for automated docking, result extraction, and PyMOL visualization

Clinical Biochemistry Intern (On-job training) June 2025 | 15 Days  

PSG Hospitals and Diagnostics Centre, Coimbatore  

• Gained hands-on exposure to serum/plasma sample processing and Cobas analyser (ISE, c503, e801) operations
• Assisted in QC documentation and safety protocol adherence in a regulated diagnostic lab

• Drug Hunting: The Science of Making New Medicines — Novartis / Coursera (2025)
• Chemical Biology — University of Geneva / Coursera (2025)
• Bioinorganic Chemistry — IIT Kanpur / NPTEL (2025)
• Introduction to Molecular Drug Discovery — University of Cape Town (2024)
• Google Project Management Professional Certificate — Google (2024)
• Aspire Leadership Program — Aspire Institute / Harvard University (2024)
• Basics in Inorganic Chemistry — IIT Bombay / NPTEL (2022)

PwD (Hearing Impaired, 50%),(Low vision,20%)

Languages: Tamil (native), English (professional)