Rajasekar s
Bengaluru
Summary
Principal Scientist at Syngene International with 15+ years of experience in preparative HPLC, SFC, and analytical/preparative chromatography for pharmaceutical and CRO programs. Expert in purification method development, optimization, scale-up, compound isolation, impurity removal, and mg-to-gram-scale purification of complex synthetic molecules and peptides. Skilled in leading purification projects, troubleshooting chromatographic and instrument issues, training junior scientists, and driving SQDECC-driven improvements in safety, quality, delivery, cost, and compliance. Recognized for improving purification success, turnaround time, lab productivity, and audit readiness through structured method development and continuous-improvement initiatives.
Overview
1
1
Language
3
3
years of post-secondary education
18
18
years of professional experience
Work History
Principal Scientist in analytical R&D
Sygène international ltd
Bengaluru
08.2011 - Current
- Drive method robustness studies, impurity/isomer separation strategies, and scale-up from analytical to preparative chromatography.
- Mentor scientists and analysts on chromatography method development, instrument operation, troubleshooting, documentation, and regulatory/data-integrity practices.
- Contribute to lab automation, workflow standardization, instrument utilization, and continuous-improvement initiatives, reducing turnaround time and improving operational efficiency.
- Coordinate preventive maintenance, vendor support, qualification/calibration activities, and resolution of instrument-related issues to maintain lab readiness.
- Prepared high-quality technical reports, project updates, presentations, and client communications.
- Managed laboratory operations, maintained equipment and procured supplies to support uninterrupted research activities.
- Collaborated with project stakeholders to clarify and fulfill project requirements effectively.
- Led end-to-end analytical and preparative purification projects for small molecules, peptides, and complex intermediates, supporting discovery, process research, and CRO client deliverables.
- Develop, optimize, and troubleshoot HPLC/UPLC, preparative HPLC, flash chromatography, SFC, and mass-directed purification methods to improve purity, recovery, throughput, and cycle time.
- Review chromatographic data, purity/assay results, mass spectral data, and purification reports to ensure scientific quality, data integrity, and compliance with SOPs and client expectations.
- Drive method robustness studies, impurity/isomer separation strategies, and scale-up from analytical to preparative chromatography.
- Contribute to lab automation, workflow standardization, instrument utilization, and continuous-improvement initiatives, reducing turnaround time and improving operational efficiency.
- Coordinate preventive maintenance, vendor support, qualification/calibration activities, and resolution of instrument-related issues to maintain lab readiness.
- Prepare high-quality technical reports, project updates, presentations, and client communications; support audits, investigations, and CAPA activities.
- years of experience in analytical and preparative chromatography, purification method development, and CRO project delivery. Expertise in HPLC/UPLC, mass-directed prep purification, SFC/flash chromatography, impurity isolation, method optimization, scale-up, and data integrity. Proven ability to lead cross-functional teams, manage client-facing projects, troubleshoot complex separations, and improve purification recovery, throughput, and laboratory productivity.
- For an analytical/prep-lab Principal Scientist resume, include: preparative HPLC, mass-directed purification, UPLC/HPLC method development, chiral separation, SFC, flash chromatography, peptide purification, impurity isolation, method validation/robustness, scale-up, LC-MS, data integrity, GxP, SOPs, CAPA, CRO project management, client communication, lab automation, instrument troubleshooting, mentoring, and continuous improvement.
- Mention the business unit if relevant, such as Discovery Services, Integrated Drug Discovery, Chemical Development, or Analytical Sciences.
- If applying externally, add one line on impact: "Recognized for improving purification efficiency and enabling timely delivery of complex client programs."
Junior Executive Trainee
Micro lab
Bengaluru
07.2009 - 08.2011
- Designed and executed accelerated and long-term stability studies per ICH guidelines, including protocol preparation, sample evaluation, and data trending to assess formulation stability.
- Performed HPLC method development for solid oral dosage forms, including tablets, capsules, and blends, using UV/PDA detection and chromatography software such as Empower.
- Optimized chromatographic conditions including column selection, mobile phase, pH, flow rate, injection volume, gradient program, and detection wavelength to achieve suitable resolution, sensitivity, and runtime.
- Executed HPLC method validation activities covering specificity, linearity, accuracy, precision, robustness, solution stability, filter compatibility, and system suitability.
- Developed or supported analytical methods for assay, content uniformity, dissolution, related substances, and other formulation-specific quality attributes.
- Performed routine HPLC system suitability checks, calibration support, troubleshooting, and preventive maintenance coordination to ensure reliable instrument performance.
Junior Analyst
Global calcium pvt ltd
Hosur
06.2008 - 07.2009
- Developed and validated analytical methods for raw materials, intermediates, impurities, and non-compendial finished API product, ensuring compliance and reliability.
- Supported plant trials through troubleshooting and evaluation of process performance during demonstration batches and commercial-scale campaigns, contributing to successful project outcomes.
- Provided support for plant trials by assisting in troubleshooting and evaluating processes, troubleshooting, and process-performance evaluation during demonstration batches and commercial-scale campaigns.
- Prepared and reviewed SOPs, development reports, experimental records, specifications, master documents, and technical data packages to maintain high-quality standards and regulatory compliance.
- Reviewed and prepared standard operating procedures and technical documents to ensure compliance with regulatory standards.
Education
M.Sc..M.Phil - Chemistry
Tuk Arts college-Bhrathidhasan university
Thanjavur 07.2006 - 04.2009
Skills
- HPLC development
Languages
English
First Language
Timeline
Principal Scientist in analytical R&D
Sygène international ltd
08.2011 - Current
Junior Executive Trainee
Micro lab
07.2009 - 08.2011
Junior Analyst
Global calcium pvt ltd
06.2008 - 07.2009
M.Sc..M.Phil - Chemistry
Tuk Arts college-Bhrathidhasan university
07.2006 - 04.2009