Ramesh Khule
Hyderabad
Summary
To obtain a challenging role in ADL, Research & Development, Product Development, or Technical Assistance Quality Management in a well-reputed organization.
Experience: 14+ years in Medicinal Chemistry, CRO, and API fields, specializing in Analytical Development Laboratory (ADL).Skills: Expertise in quality systems implementation, problem-solving, project management, and analytical troubleshooting.Technical Proficiency: Experienced in process development of FFS, FTE, and custom manufacturing projects. Proficient in purification techniques, including preparative HPLC and lyophilization, particularly in the context of medicinal chemistry, peptides, nucleotides, lipids, carbohydrates, macrocyclic, and heterocyclic compounds.Attributes: Flexible, dedicated, and passionate about ADL; strong analytical and communication skills.
Overview
14
14
years of professional experience
Work History
Research Scientist - Analytical R&D
Sai Life Sciences Ltd.
04.2017 - Current
- Lead a team of scientists focusing on LCMS and HPLC analytical activities, including methodology development, routine analysis, and finished product analysis
- Collaborate with the chemistry team, providing technical inputs on HPLC, LCMS, and MS studies
- Perform calibration, troubleshooting, and maintenance of LCMS, HPLC, and SOR instruments
- Develop and execute analytical methods for reaction monitoring, intermediate, and final analysis
- Maintain lab equipment, ensure precise analysis, and manage turnaround times
- Purification: Oversee and perform the purification of compounds using preparative HPLC
- Optimize purification conditions to ensure the highest purity and yield
- Conduct subsequent lyophilization for the drying and stabilization of purified fractions.
Assistant Manager - Analytical R&D
Delta Finochem Pvt. Ltd.
03.2014 - 04.2017
- Led a team responsible for analytical activities, method development, and data evaluation
- Managed lab equipment maintenance as per GMP/GLP standards, including instrument calibration
- Conducted analysis using HPLC, GC, LCMS, and other separation techniques
- Reviewed COAs, analysis ATRs, mass analysis, and calibration data
- Provided analytical support and problem-solving for product development and stability testing
- Developed LC-MS methods, impurity profiling, and analytical investigation reports.
Senior Research Chemist - Analytical R&D
Sai Life Sciences Ltd.
08.2010 - 03.2014
- Conducted molecular weight determination and structure elucidation using LCMS and mass spectrometry
- Performed reaction monitoring and in-process analysis using HPLC and LCMS
- Purification: Managed the purification of complex compounds by preparative HPLC, followed by lyophilization to obtain pure, stable products
- Developed and optimized purification protocols for new chemical entities and impurities
- Calibrated and maintained HPLC instruments.
Education
M.Sc. - Analytical Chemistry
Pune University
06-2010
B.Sc. - Chemistry
Pune University
05-2006
Skills
- Expertise in quality systems implementation
- Problem-solving
- Project management
- Analytical troubleshooting
- Experienced in process development of FFS
- FTE
- And custom manufacturing projects
- Proficient in purification techniques
- Including preparative HPLC and lyophilization
- Particularly in the context of medicinal chemistry
- Peptides
- Nucleotides
- Lipids
- Carbohydrates
- Macrocyclic
- And heterocyclic compounds
- Flexible
- Dedicated
- Passionate about ADL
- Strong analytical skills
- Communication skills
Languages
English
Upper Intermediate
B2
Hindi
Advanced
C1
Timeline
Research Scientist - Analytical R&D
Sai Life Sciences Ltd.
04.2017 - Current
Assistant Manager - Analytical R&D
Delta Finochem Pvt. Ltd.
03.2014 - 04.2017
Senior Research Chemist - Analytical R&D
Sai Life Sciences Ltd.
08.2010 - 03.2014
M.Sc. - Analytical Chemistry
Pune University
B.Sc. - Chemistry
Pune University
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