Summary

Overview

Work History

Education

Skills

Accomplishments

Certification

Languages

Affiliations

References

Timeline

SADHISH I V

Bangalore

Summary

Experienced scientist well-versed in in vitro experiments,automation and bioanalysis looking for challenging new role with progressive organization. Bringing 7 years of experience in vitro ADME DMPK. Highly-motivated with desire to take on new challenges,strong worth ethic, adaptability and exceptional interpersonal skills. Adept at working effectively unsupervised and quickly mastering new skills.

Overview

years of professional experience

Certification

Work History

Scientist ADME DMPK

TCG Life sciences

Kolkata

03.2022 - Current

Led the design, coordination, planning, execution, and analysis of in vitro ADME DMPK experiments for the screening and progression of novel small molecules.
Directed and oversaw setup, validation, and optimization of fully automated Pion Sirius T3 for the determination of physicochemical properties (pKa, Log P, Log D, and solubility).
Acquired proficiency and certification in the operations and maintenance of Pion Sirius T3.
Preparation and review of client presentation and reports for Sirius T3 generated data.
Routine meetings with clients and handling inquiries and addressing concerns related to our ADME data.
Acquired proficiency in programming and script writing of automated liquid handlers (Tecan Evo Fluent, Biomek i7, Integra via flow Apricot S3)
Oversaw implementation and integration of high throughput strategies using automated liquid for in-vitro assay protocols.
Orchestrated on refining and transitioning in vitro assay from 96 to 384 well plates to improve high throughput and reduction of assay volumes.
Collaborated in the setup of in vitro ADME DMPK laboratory.
Design, develop, and optimize physicochemical assays to evaluate the key properties of small molecules, including solubility (Kinetic and Thermodynamic), chemical stability, pKa determination, lipophilicity (Log D, Log P), permeability (PAMPA).
Execution of binding assays involving plasma proteins, microsomes, albumin, hepatocytes by RED method and blood-to-plasma partitioning (Direct and indirect method)
Evaluation of small molecule NCEs for potential drug-drug interactions IC50, MBI/TDI IC50 shift assay,KI Kinact & CYP Phenotyping.
Development and optimization of metabolic clearance assays utilizing microsomes, hepatocytes, S9 fractions, cytosol, and blood.
Basic understanding and knowledge on permeability studies using CACO2 and MDCK cell lines.
Drafting and evaluating protocols for developmental in-vitro ADME assays.
Performing regular maintenance and calibration to ensure the reliability of automated liquid handling systems.
Training, instructing and guiding subordinates in the use of automated liquid handling solutions.
Compiling bio-analytical information , interpreting scientific data, and creating comprehensive study reports for client communication.
Developing study work plan in alignment with guidance from the Study Director and conveying to the cross functional team.
Engaging in and supporting pre-initiation and study-related meetings alongside the Study Director.
Conducted a presentation for team members on the Pion Sirius T3 and relevance to drug ionization and its impact of various physicochemical and ADME properties
Evaluating in-vitro ADME data and collaborating with team members on designated projects.
Proficiently utilizing software such as MS Office, Graph Pad Prism, SoftMax Pro, and Skanit for data analysis and the creation of reports.
Managing consumables inventory and overseeing laboratory maintenance.
Ensuring that the study adheres to the protocol and standard operating procedures (SOPs).

Research Associate II DMPK

Aurigene Discovery Technologies Limited

Bangalore

06.2021 - 03.2022

Planning and execution, and analysis of in vitro ADME DMPK experiments for the screening and progression of novel small molecules.
Practical expertise with AB Sciex Mass Spectrometry instruments (4000, 5000, 5500), Shimadzu LC Prominence, tuning of small molecules, method development, batch preparation, and quantification of small molecules
Participated in studies with Investigational New Drug (IND) applications, focusing on designing assays and conducting various in-vitro assays, including Protein Binding (PPB), Microsomal Binding, Microsomal and Hepatocyte Stability, Drug-Drug Interaction (DDI), and (MBI/TDI)
Played a crucial role in the optimization of in vitro assays, transitioning them from a tube-based model to a 96-well plate-based model.
Drafting and evaluating in vitro assay protocols for Discovery and IND enabled studies.
Revising the reports for studies supporting Investigational New Drug (IND) applications.
Regularly involved in delivering scientific presentations.
Creating and examining internal standard operating procedures, reports, and protocols.
Analyzing the data obtained from experiments, often involving the use of software and statistical methods to interpret results.
Recording experimental procedures, results, and conclusions accurately in laboratory notebooks and eLNBs as per ALCOA+.

Senior Research Associate DMPK

Syngene international Ltd

Bangalore

09.2017 - 05.2021

Experienced senior research associate with expertise in conducting in-vitro assays, including metabolic stability screening, plasma protein binding (both Rapid Equilibrium Dialysis and Ultra Centrifugation), and plasma stability assessments, Solubility assay (Thermodynamic and Kinetic) and Log D.
Proficiency in operating liquid handling systems such as Biomek i5, Nxp, and Fxp
Completed training and certification under the guidance of Beckman automation & pipetting specialist to enhance volume dispensing accuracy and improve assay protocols by utilizing the Biomek i5 automation liquid handling systems in ADME drug discovery.
Served as representative and first line of communication in operation and maintenance of automated liquid handlers (Biomek i5, Nxp, Fxp)
Documented the processes involved, in Electronic Lab Notebook as per ALCOA+ standards
Maintained inventory for Lab consumables (Reagents/materials) and ordering of consumables in SAP.
Delivered efficient and high-quality data by adhering to the timelines and ensured there were no bottlenecks, to the client.
Delivered routine scientific presentations in collaboration with team members.

Senior Subject Matter Expert, Biology & Chemistry (Part Time)

R30 Foundations & Brysen’s academy

01.2018 - Current

Demonstrated proficiency in preparing students for competitive exams, including NEET, JEE with a track record of successful results
Designed and implemented tailored study plans and curriculum, aligning with the unique requirements and syllabus of competitive exams
Utilized innovative teaching methods and resources to simplify complex concepts, ensuring students' comprehensive understanding including physical demonstrations, drawn illustrations and visual presentations
Trained over 3000 students in the last 5 years for The National entrance cum eligibility test (All India premedical entrance test) and various other competitive exams in India
Ability to effectively use subject-specific educational technology tools and software.

Education

M Pharm -

JSS College of Pharmacy

01.2017

B Pharm -

Jaya College of Pharmacy

01.2015

Skills

In-vitro ADME assay
Automation Liquid handlers
Programming and scripting
Pion Sirius T3
LCMS/HPLC
Method Development
Data integrity and compliance
ALCOA
Inventory management
Mentoring and training
High throughput screening
Handling laboratory animals
Animal dosing
Tissue slicing
Enzyme kinetics
Cell culture
Caco2, MDCK
UV and Visible spectroscopy
IND enabled studies
Data analysis & interpretation
Report Preparation

Documentation
SOP preparation
Microsoft office
Experimental design
Animal Handling
Presenting at conferences
Research background
Laboratory Experiments
Writing reports
Statistical Data Analysis
Equipment Maintenance
Project Coordination
Graph pad prism
Communication & Presentation
Leadership
Budget Management
Specimen Collection
Grant proposal development
Research proficiency
Monitoring procedures
Research management

Accomplishments

Sri Bhojaraj Ponjooomal Gold Medal “Best outgoing student in M. Pharmacy for academic year 2017”.
I.P.A Nilgiris Branch Silver medal Award 2017
Prof K. Chinnaswamy endowment gold medal
The TamilNadu Dr M.G.R medical university medal
IDMA J.B. mody best student award for the year 2015
Tamilnadu pharmacy council Fourrts India merit award
Spot Award for writing and optimizing protocols in automation

Certification

Certification in operations and maintenance of Pion Sirius T3.
Certification in the handling and maintenance of Biomek i7,i5 and Tecan liquid handlers

Languages

English

First Language

Tamil

Upper Intermediate (B2)

Hindi

Intermediate (B1)

Affiliations

Scientist,passionate teacher and fitness trainer.

References

References available upon request.

Timeline

Scientist ADME DMPK

TCG Life sciences

03.2022 - Current

Research Associate II DMPK

Aurigene Discovery Technologies Limited

06.2021 - 03.2022

Senior Subject Matter Expert, Biology & Chemistry (Part Time)

R30 Foundations & Brysen’s academy

01.2018 - Current

Senior Research Associate DMPK

Syngene international Ltd

09.2017 - 05.2021

M Pharm -

JSS College of Pharmacy

B Pharm -

Jaya College of Pharmacy

SADHISH I V

Summary

Overview

Work History

Scientist ADME DMPK

Research Associate II DMPK

Senior Research Associate DMPK

Senior Subject Matter Expert, Biology & Chemistry (Part Time)

Education

M Pharm -

B Pharm -

Skills

Accomplishments

Certification

Languages

Affiliations

References

Timeline

Scientist ADME DMPK

Research Associate II DMPK

Senior Subject Matter Expert, Biology & Chemistry (Part Time)

Senior Research Associate DMPK

M Pharm -

B Pharm -

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