SANTOSH KUMAR
Bangalore
Judge a man by his questions rather than his answers.
Voltaire
Summary
Molecular biologist with a demonstrated history of research in academic institutions and product development in the biotech industry. Skilled in molecular biology, biochemistry, genomics, bioinformatics, and molecular diagnostics. Strong research professional with a Ph.D. degree in Biochemistry from CFTRI/University of Mysore and an MSc focused in Biotechnology from Karnatak University Dharwad.
Overview
11
11
years of professional experience
Work History
Computational Biologist
Katamaran Industries Private Limited
11.2023 - Current
- Designing machine learning-based Drug response prediction workflow for patient stratification.
- Pharmaco-transcriptomics based target discovery for protein tyrosine kinase inhibitors.
- Generative Adversarial Network based Deep Learning algorithms for novel de novo drug design.
Adjunct Faculty
M. S. Ramaiah University of Applied Sciences
Bangalore, Karnataka
2023.12 - Current
Teaching an introductory course on bioinformatics and interacting with undergraduate students to generate interest in computational biology.
Research Scientist (Molecular Biology)
BreathX India Pvt. Ltd.(Canary Global Inc Company)
12.2021 - 01.2023
- Research and development of molecular diagnostic assays for early detection of lung cancer and SARS COVID.
- Prepared project proposals, completion reports, and FDA regulatory compliance documentation.
Postdoctoral Research Fellow
Tel Aviv University
03.2017 - 04.2019
- Designed and conducted Mycobiome sequencing experiments using Illumina MiSeq to decipher endophytic fungal diversity and to identify beneficial candidates of agronomic importance.
- Maintained accurate records of research findings, designed bioinformatics pipeline and provided statistical analysis and interpretation of metagenomics sequencing data results.
Post Doctoral Research Fellow
The University of Malaya
08.2013 - 06.2016
- Designed bioinformatics pipeline for Genome-wide secretome prediction, followed by experimental evidence by analyzing composite transcriptome of Fusarium oxysporum fs cubense and banana root.
- In planta expression of candidate Fusarium effector genes in banana root to identify host-pathogen protein-protein interactions (in collaboration with Krogan Lab, UCSF, USA).
Senior Research Scientist
Bhat Biotech India (P) Ltd
07.2012 - 07.2013
- Performed recombinant expression and purification of HIV (gp 41 and gp36), HCV (Env), Dengue (NS1 and Env), and Malaria (pfMSP & pLDH) in E. Coli to improve their diagnostic utility.
- Designed sero-diagnostic assays using Chicken IgY antibodies against recombinant plant viral capsid proteins [Papaya ring spot virus (PRSV) and Banana bunchy top virus (BBTV) coat proteins.
- As manager of the contract research facility supervised team of 8-10 junior scientists.
Education
Ph.D. - Biochemistry And Molecular Biology
07.2013
Master of Science - Biotechnology
06.2005
Bachelor of Science - Biology
05.2003
Skills
- Molecular biology
- Next-generation Sequencing data analyses
- Genomics and Bioinformatics
- Molecular diagnostics
- Recombinant protein expression and purification
- Polyclonal antibodies, ELISA and Western blot
- FDA Regulatory documentation and compliance
- Linux, R and Biostatistics
- Manuscript preparation and review for publications in peer-reviewed journals
- Student Research Guidance
- Lecture Development
- Learning Strategies
Languages
English
Bilingual or Proficient (C2)
Kannada
Bilingual or Proficient (C2)
Hindi
Bilingual or Proficient (C2)
Timeline
Adjunct Faculty - M. S. Ramaiah University of Applied Sciences
2023.12 - Current
Computational Biologist - Katamaran Industries Private Limited
11.2023 - Current
Research Scientist (Molecular Biology) - BreathX India Pvt. Ltd.(Canary Global Inc Company)
12.2021 - 01.2023
Postdoctoral Research Fellow - Tel Aviv University
03.2017 - 04.2019
Post Doctoral Research Fellow - The University of Malaya
08.2013 - 06.2016
Senior Research Scientist - Bhat Biotech India (P) Ltd
07.2012 - 07.2013
CSIR-CFTRI And University of Mysore - Ph.D., Biochemistry And Molecular Biology
Karnataka University - Master of Science, Biotechnology
Karnataka University - Bachelor of Science, Biology
Fellowships
- DBT-Junior Research Fellow /Senior Research Fellow Department of Biotechnology (DBT), New Delhi, India (2006 - 2012)
- GATE (Graduate Aptitude Test in Engineering and Life sciences IISc, Bangalore & IIT-Kharagpur PERCENTILE: 94.74 (2006)
- CSIR-UGC National Eligibility Test (NET) for lectureship Council for Scientific and Industrial Research (CSIR) & University Grants Commission (UGC), New Delhi, India. (2005)
Presentations
- The complete chloroplast genome of Musa balbisiana, 3rd Plant Genomics Congress Asia, 04/11/16, Kuala Lumpur, Malaysia
- Genome-based discovery of secretome of Fusarium oxysporum fs cubense and identification of effectors involved in early infection of banana, 22nd Annual meeting of Malaysian Society for Molecular biology and Biotechnology, 09/08/15, Kuala Lumpur, Malaysia
- Attended the workshop on 'Fungal endophytes: undercover agents within plants', 14th European Conference on Fungal Genetics (ECFG14), 02/25/18, Haifa, Israel
- Fluorescent In situ hybridization (FISH) and Chromatin immune precipitation (ChIP) workshop for plant genetic study, 12/17/13, Serdang, Malaysia
Work Availability
monday
tuesday
wednesday
thursday
friday
saturday
sunday
morning
afternoon
evening
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Publications
- Shetty SM, Md Shah MU, Makale K, Mohd-Yusuf Y, Norzulaani Khalid N, Othman RY (2016) The complete chloroplast genome sequence of Musa balbisiana (Musaceae) corroborates the structural heterogeneity of inverted repeats in wild progenitors of cultivated bananas and plantains, The Plant Genome, 9(2), 10.3835/plantgenome2015.09.0089,
- Shetty SM, Chandrashekar A, Venkatesh YP (2012) Promoter analyses and transcriptional profiling of the eggplant polyphenol oxidase 1 gene (SmePPO1) reveal differential response to exogenous methyl jasmonate and salicylic acid, Journal of Plant Physiology, 169, 718-730.
- Shetty SM, Chandrashekar A, Venkatesh YP (2011) Eggplant polyphenol oxidase multigene family: Cloning, phylogeny, expression analyses and immunolocalization in response to wounding, Phytochemistry, 72, 2275-87.
- Ashok Kumar HG, Hegde VL, Shetty SM, Venkatesh YP (2013) Characterization and gene cloning of an acidic thaumatin-like protein (TLP 1), an allergen from sapodilla fruit (Manilkara zapota), Allergol Int, 62, 447-462.
Fellowships
- DBT-Junior Research Fellow /Senior Research Fellow Department of Biotechnology (DBT), New Delhi, India (2006 - 2012)
- GATE (Graduate Aptitude Test in Engineering and Life sciences IISc, Bangalore & IIT-Kharagpur PERCENTILE: 94.74 (2006)
- CSIR-UGC National Eligibility Test (NET) for lectureship Council for Scientific and Industrial Research (CSIR) & University Grants Commission (UGC), New Delhi, India. (2005)
Presentations
- The complete chloroplast genome of Musa balbisiana, 3rd Plant Genomics Congress Asia, 04/11/16, Kuala Lumpur, Malaysia
- Genome-based discovery of secretome of Fusarium oxysporum fs cubense and identification of effectors involved in early infection of banana, 22nd Annual meeting of Malaysian Society for Molecular biology and Biotechnology, 09/08/15, Kuala Lumpur, Malaysia
- Attended the workshop on 'Fungal endophytes: undercover agents within plants', 14th European Conference on Fungal Genetics (ECFG14), 02/25/18, Haifa, Israel
- Fluorescent In situ hybridization (FISH) and Chromatin immune precipitation (ChIP) workshop for plant genetic study, 12/17/13, Serdang, Malaysia
Publications
- Shetty SM, Md Shah MU, Makale K, Mohd-Yusuf Y, Norzulaani Khalid N, Othman RY (2016) The complete chloroplast genome sequence of Musa balbisiana (Musaceae) corroborates the structural heterogeneity of inverted repeats in wild progenitors of cultivated bananas and plantains, The Plant Genome, 9(2), 10.3835/plantgenome2015.09.0089,
- Shetty SM, Chandrashekar A, Venkatesh YP (2012) Promoter analyses and transcriptional profiling of the eggplant polyphenol oxidase 1 gene (SmePPO1) reveal differential response to exogenous methyl jasmonate and salicylic acid, Journal of Plant Physiology, 169, 718-730.
- Shetty SM, Chandrashekar A, Venkatesh YP (2011) Eggplant polyphenol oxidase multigene family: Cloning, phylogeny, expression analyses and immunolocalization in response to wounding, Phytochemistry, 72, 2275-87.
- Ashok Kumar HG, Hegde VL, Shetty SM, Venkatesh YP (2013) Characterization and gene cloning of an acidic thaumatin-like protein (TLP 1), an allergen from sapodilla fruit (Manilkara zapota), Allergol Int, 62, 447-462.
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