Shabnam Hussain
Guwahati
Summary
Experienced Genome Analyst specializing in data curation for cancer genomics, with a proven ability to organize, refine, and manage large-scale genomic datasets to ensure accuracy and usability. Proficient in applying bioinformatics methodologies to structure high-quality genomic data, facilitating meaningful analyses and actionable insights for clinical research. Well-versed in best practices for data standardization, annotation, and integration, contributing to the development of genomic knowledgebases that drive scientific advancement. Dedicated to continuous learning and the adoption of emerging technologies to optimize data workflows and enhance accessibility, supporting innovation in genomic research.
Overview
7
7
years of professional experience
1
1
Certification
Work History
Biocurator
Velsera
Pune
08.2024 - Current
- Interpreted clinical literature to extract biologically and genomically relevant insights for research and diagnostic applications.
- Curated, annotated, and managed structured datasets to support high-quality clinical genomics workflows.
- Captured and documented variant-disease relationships using standardized ontologies (e.g., HGNC, OMIM, SNOMED), and established curation guidelines.
- Applied advanced domain expertise to ensure scientific accuracy and consistency across curated content.
- Contributed to the development and refinement of curation pipelines, adapting strategies to evolving project needs and regulatory standards.
- Designed and executed test cases to validate knowledge base content, including variant annotations, rule logic, and ontology mappings.
- Identified process risks and reported deviations from SOPs and work instructions to maintain compliance and data integrity.
- Conducted both manual and automated validation of literature references, gene-disease associations, and clinical interpretations.
- Participated in software and system testing to ensure platform reliability and content accuracy.
- Translated complex biological data into logical frameworks that support IVD-grade clinical decision-making tools.
- Maintained and optimized literature triage workflows, and quality control mechanisms, to uphold curation standards.
- Collaborated with cross-functional teams to align product understanding with the end-to-end knowledge base development.
Senior Genome Analyst
4basecare Oncosolutions Pvt Ltd
Bengaluru
05.2022 - 07.2024
- Led complex genomic data interpretation, focusing on oncology variant analysis.
- Collaborated with clinicians, bioinformatics teams, and business units to resolve queries.
- Designed and refined analysis pipelines and reporting strategies for enhanced efficiency.
- Reviewed scientific literature to support variant classification and clinical relevance.
- Utilized platforms like Integrated Genome Viewer (IGV) for effective variant analysis.
- Participated in internal research projects and contributed to assay development efforts.
- Identified process risks, ensured regulatory compliance, and guided genomic strategy.
- Supervised genome analysts to ensure timely report delivery aligned with turnaround goals.
Scientific Officer
Positive Biosciences
Mumbai
12.2019 - 05.2022
- Analyzed next-generation sequencing (NGS) data to identify variants and mutations according to clinical guidelines.
- Annotated and interpreted genetic variants for disease predisposition and treatment relevance.
- Collaborated with bioinformatics and lab teams to produce high-quality clinical reports within designated timelines.
- Reviewed scientific literature systematically to support variant classification and establish clinical relevance.
- Utilized platforms like Integrated Genome Viewer (IGV) and bioinformatics tools for effective variant analysis.
- Contributed to standard operating procedures (SOPs) and internal policies for genomic workflows.
BCIL Trainee
IPCA Laboratories Pvt Ltd
Mumbai
11.2018 - 05.2019
- Completed a 6-month training program, focusing on biosimilar development and analytical techniques. Gained hands-on experience in chromatography methods, including HPLC and UPLC, for quality assessment and molecular characterization.
- Shadowed daily activities of office staff to gain an understanding of the scope of work.
Education
Master of Science - Biotechnology
Lovely Professional University
Punjab06-2018
Bachelor of Science - Biotechnology
Pandu College
Assam07-2016
Skills
- Genomic Data Curation & Annotation
- Variant Interpretation & Ontology Mapping
- Literature Review & Rule-Based Logic Development
- Knowledgebase Validation & Quality Control
- Team leadership
- Problem solving
- Attention to detail
- Cross-functional collaboration
- Mentoring trainees
- Teamwork and collaboration
- Multitasking
Certification
- Clinical Trials Operations, Coursera, https://coursera.org/share/767e1aebd9c6d662881a88781adc6215
- Improving healthcare through clinical research, Future Learn, https://www.futurelearn.com/certificates/7l729yy
- Decoding drug safety: your passport to pharmacovigilance, Udemy, https://www.udemy.com/certificate/UC-f73d622b-7a8f-471f-96e6-67430ef238a5
Knowledge And Expertise
- Applied cancer-specific biomarkers in accordance with ACMG/AMP, NCCN, ESMO, and ASCO guidelines
- Conducted a literature-based classification of CNV and fusion variants
- Assessed immunotherapy-related biomarkers, including TMB, MSI, and PD-L1, to support clinical decision-making
- Integrated genomic annotations to enhance the accuracy of genomic data analysis.
- Utilized specialized databases to annotate and interpret genetic variants.
- Demonstrated a strong understanding of oncology-related treatments and therapeutic strategies
- Evaluated inclusion and exclusion criteria for CTGov and EUCTR clinical trial registries
- Skilled in assessing medical documentation for research and clinical applications
- Analyzed preclinical studies to identify novel insights into the significance of cancer-associated variants.
- Hands on with AWS platform.
Timeline
Biocurator
Velsera
08.2024 - Current
Senior Genome Analyst
4basecare Oncosolutions Pvt Ltd
05.2022 - 07.2024
Scientific Officer
Positive Biosciences
12.2019 - 05.2022
BCIL Trainee
IPCA Laboratories Pvt Ltd
11.2018 - 05.2019
Master of Science - Biotechnology
Lovely Professional University
Bachelor of Science - Biotechnology
Pandu College
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