Shaik Naseer Pasha PhD

Seasoned professional experienced in design, implementation of experimental and computational pipeline for R&D and turnkey-commercial solutions. He bring 10+ years of experience in life sciences and project management through focused team building and leadership in execution of milestones and deliverables. Skilled in the field of Molecular Biology, Biochemistry, Genomics, Transcriptome, Clinical Diagnostics, Structural Bioinformatics and data management from plant and animal sources. Managed as a team leader for four years working as Senior Scientist in Biotechnology industry. Technically skilled in molecular and open-source bioinformatics tools for sequence, structure and functional analysis, bash scripting, Python and R programming. His PhD research work was focused on genome-wide analysis of protein families of molecular motors to provide integrative and robust classification, Structure-function analysis of Beta Cardiac Myosin mutations associated to cardiomyopathies, and genome analysis of medicinal plants

1· Shaik Naseer Pasha., et. al. (2021). Ancient Migrations - The first complete genome assembly, annotation and variants of the Zoroastrian-Parsi community of India, bioRxiv. 2021 Feb, doi: https://doi.org/10.1101/2021.02.17.431362

2· Gayatri Kumar, Kashyap Krishnasamy, Shaik Naseer Pasha ., et. al. (2021) Dynamic methylome modification is associated with mutational signatures in aging and the etiology of disease, bioRxiv, 2021 Feb, doi: https://doi.org/10.1101/2020.12.22.423778

3· Villoo Morawala Patell, Shaik Naseer Pasha., et. al. (2020). The First complete Zoroastrian-Parsi Mitochondria Reference Genome: Implications of mitochondrial signatures in an endogamous, non-smoking population, Metagene (in press)

4· Adwait G.Joshi, K.Harini, Iyer Meenakshi, K. Mohamed Shafi, Shaik Naseer Pasha, Jarjapu Mahita, Radha S.Vinekar.. Ramanathan Sowdhamini (2020) A knowledge-driven protocol for prediction of proteins of interest with an emphasis on biosynthetic pathways. MethodX. DOI: 10.1016/j.mex.2020.101053

5· Shaik Naseer Pasha, Mathew, O. K. et. al. (2019). The transcriptome enables the identification of candidate genes behind medicinal value of Drumstick tree ( Moringa oleifera ), Genomics , https://doi.org/10.1016/j.ygeno.2019.04.014

6· K Mohamed Shafi, Adwait G Joshi, Iyer Meenakshi, Shaik Naseer Pasha., et. al. (2020). Dataset for the combined transcriptome assembly of M. oleifera and functional annotation, Data in Brief, https://doi.org/10.1016/j.dib.2020.105416

7· Saswata S Sarkar, Darshan V Trivedi, Makenna M Morck, Arjun S Adhikari, Shaik Naseer Pasha, Kathleen M Ruppel, James A Spudich (2020). The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin. Science Advances, DOI: 10.1126/sciadv.aax0069

8· Shaik Naseer Pasha, Iyer Meenakshi and R. Sowdhamini (2016). Re-visiting myosin families through large-scale sequence searches leads to the discovery of new myosins. Evolutionary Bioinformatics, doi: 10.4137/EBO.S39880

9· Rajas M Rao, Shaik Naseer Pasha and Ramanathan Sowdhamini. (2016) Genome-wide survey, phylogeny and modelling of LuxS protein. BMC Genomics, https://doi.org/10.1186/s12864-016-3002-x

10· A. K. Upadhyay, A. R. Chacko, Shaik Naseer Pasha and R. Sowdhamini. (2015). Genome sequencing of herb Tulsi (Ocimum tenuiflorum) unravels key genes behind its strong medicinal properties. BMC Plant Biology, https://doi.org/10.1186/s12870-015-0562-x

11· A. Gandhimathi, P. Ghosh, K. Harini, A. P. Joseph, A. G. Joshi, S. D. Karpe, S. Kaushik, N. Kuravadi, C. S Lingu, J. Mahita, R. Malarini, S. Malhotra, M. Malini, O. K. Mathew, E. Mutt, M. Naika, S. Nitish, Shaik Naseer Pasha and R. Sowdhamini. (2015). Draft Genome of Cissus quadrangularis to Elucidate the Medicinal Values. Herbal Medicine, DOI: 10.21767/2472-0151.10007

12· Divya P. Syamaladevi, Margaret S Sunitha, S. Kalaimathy, Chandrashekar C. Reddy, Mohammed Iftekhar, Shaik Naseer Pasha, and R. Sowdhamini. (2012). Myosinome: A Database of Myosins from Select Eukaryotic Genomes to Facilitate Analysis of Sequence-Structure-Function Relationships. Bioinform Biol Insights, DOI: 10.4137/BBI.S9902

• Patent Title - Mitochondrial DNA mutations in Zoroastrian Parsi haplogroups - Implications of mitochondrial signatures in cancers, neurodegenerative disorders, metabolic and rare diseases [Patent Application No. 202041023042, Dated 2/6/2020]
• Copyright - The First Complete Zoroastrian-Parsi Mitochondrial Reference Genome and Genetic Signatures of an Endogamous Non-smoking Population [ Diary No.: 6972/2021-CO/L]

• Executive committee member and scientific advisor for hallilabs which is an association for improving science education with school kids and college students. I also volunteer my services as a mentor for college students for executing research-based pedagogy in bioinformatics. For more information, please visit http://hallilabs.org/

• Dr. Ramanathan Sowdhamini,

Professor, Bioinformatics, NCBS

GKVK, Bangalore - 560065

Ph: +91-80-23666250

E-mail: mini@ncbs.res.in

• Dr. Vijay Raghavan,

Professor, Genetic analysis of sensory and motor systems and BioPhysics,

NCBS, GKVK, Bangalore - 560065

Ph: +91-80-2366 6040

E-mail: vijay@ncbs.res.in

• Dr. James A. Spudich

Douglass M. and Nola Leishman Professor, Department of Biochemistry

Stanford University School of Medicine,

Stanford, California - 94305

Ph: 650-723-7634

• Dr. Shamith Samarajiwa

Group leader,

MRC Cancer Unit, University of Cambridge, Biomedical Campus

United Kingdom: CB2 0XZ

Ph: 01223763240

E-mail: ss861@mrc-cu.cam.ac.uk

E-mail: jspudich@stanford.edu