Siddharth Gusain

• 8 years of research experience in the field of Biomedical science with a major focus on drug discovery for neurological disorders.
• Proficient in scientific project writing, designing and executing laboratory bench work, data collection, analysis and interpretation.
• Effective verbal and visual presentation skills.
• Co-authored eight research articles in reputed peer-reviewed international journals.

• ICMR-SRF fellowship granted by Indian Council for Medical Research, 2019-2022
• Summer Research Fellowship Programme, IASc (Bangalore), INSA (New Delhi) and NASI (Allahabad), 2014
• Summer Undergraduate Research Training Programme, ACBR, University of Delhi, 2012

Name: Siddharth Gusain

Address: Flat no-11, A-44/45, Jawahar Park, Khanpur, New Delhi-110062, India

Date of Birth: 18/05/1992

Languages: English, Hindi

• Mishra, C. B., Shalini, S., Gusain, S., Kumar, P., Kumari, S., Choi, Y.-S., Kumari, J., Moku, B. K., Yadav, A. K., Prakash, A., Jeon, R., and Tiwari, M. (2024) Multitarget action of Benzothiazole-piperazine small hybrid molecule against Alzheimer’s disease: In silico, In vitro, and In vivo investigation. Biomed. Pharmacother. Biomedecine Pharmacother. 174, 116484.
• Mishra, C. B.*, Gusain, S.*, Shalini, S., Kumari, S., Prakash, A., Kumari, N., Yadav, A. K., Kumari, J., Kumar, K., and Tiwari, M. (2020) Development of novel carbazole derivatives with effective multifunctional action against Alzheimer’s diseases: Design, synthesis, in silico, in vitro and in vivo investigation. Bioorganic Chem. 95, 103524. (* equal contribution)
• Mishra, C. B., Shalini, S., Gusain, S., Prakash, A., Kumari, J., Kumari, S., Yadav, A. K., Lynn, A. M., and Tiwari, M. (2020) Development of novel N-(6-methanesulfonyl-benzothiazol-2-yl)-3-(4-substituted-piperazin-1-yl)-propionamides with cholinesterase inhibition, anti-β-amyloid aggregation, neuroprotection and cognition enhancing properties for the therapy of Alzheimer’s disease. RSC Adv. 10, 17602–17619.
• Umar, T., Gusain, S., Raza, M. K., Shalini, S., Kumar, J., Tiwari, M., and Hoda, N. (2019) Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer’s agents. Bioorg. Med. Chem. 27, 3156–3166.
• Umar, T., Shalini, S., Raza, M. K., Gusain, S., Kumar, J., Seth, P., Tiwari, M., and Hoda, N. (2019) A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer’s disease. Eur. J. Med. Chem. 175, 2–19.
• Umar, T., Shalini, S., Raza, M. K., Gusain, S., Kumar, J., Ahmed, W., Tiwari, M., and Hoda, N. (2018) New amyloid beta-disaggregating agents: synthesis, pharmacological evaluation, crystal structure and molecular docking of N-(4-((7-chloroquinolin-4-yl)oxy)-3-ethoxybenzyl)amines. MedChemComm 9, 1891–1904.
• Saini, V., Manral, A., Arora, R., Meena, P., Gusain, S., Saluja, D., and Tiwari, M. (2017) Novel synthetic analogs of diallyl disulfide triggers cell cycle arrest and apoptosis via ROS generation in MIA PaCa-2 cells. Pharmacol. Rep. PR 69, 813–821.
• Tanwar, A., Thakur, P., Chawla, R., Ansari, M.M., Chakotiya, A., Gusain, S., Goel, R., Arora, R., Sharma, R., Khan, H. (2017) Curative remedies for rheumatoid arthritis: Herbal informatics approach for rational based selection of natural plant products. Indian J. Tradit. Knowl. 16, 128–133.

• South African Patent #2021/09489 dated 23/02/2022

A method for designing and synthesizing carbazole based novel multifunctional agents as potential Anti-Alzheimer’s agents.

• German Patent # IPC C07D 241/04 dated 23/05/2022

A system for developing a series of 1-Phenyl-3/4-[4-(Aryl/Heteroaryl/Alkyl-piperazine-1-yl) Phenyl Urea derivatives as Anticonvulsant and Antidepressant agents.

• South African Patent #2023/02262 dated 31/05/2023

Method for synthesizing potential therapeutic agents for treating L-Name-Induced Hypertension and evaluating its effect thereof.

• Poster presentation at 11th symposium on Frontiers in Biomedical Research “Challenges in human health: Prevention, diagnosis and cure”, 19-21st February 2018, University of Delhi
• Poster presentation at National Symposium on Frontiers in Biomedical Research “Communicable and Non-communicable Diseases: Prevention, Cure, and Future Preparedness”, 2-4th November 2022, University of Delhi
• Attended GIAN course conducted by MHRD on “RNA Metabolism and Neurodegenerative Diseases”.