Simhadri Praveen Kumar

To pursue a research career in the biological based industry in a that can provide me the opportunity to grow professionally and personally.

Graduate researcher under supervision of Prof.P.Prakash Babu, University of Hyderabad

• Received Gold medal for 1st rank and University fellowship during Masters in GITAM University 2011
• Department of Science and Technology (DST- INSPIRE) fellowship 2013-2018
• Department of Biotechnology (DBT)-CTEP travel grant 2017
• Received Gold Medal for Young Scientist Award from Association of Biotechnology and Pharmacy 2017
• Summer Research Fellow (Indian National Science Academy) 2010

• Simhadri P Kumar (2016) Cofilin-1 as a possible therapeutic target to prevent cognitive sequelae in cerebral malaria. Frontiers. 14th Meeting of the Asian-Pacific Society for Neurochemistry (APSN 2016). doi: 10.3389/conf.fncel.2016.36.00127.
• SP Kumar and P.B.Phanithi (2017) Dysregulation of LIMK-1/cofilin-1 pathway: A possible basis for alteration of neuronal morphology in experimental cerebral malaria. J. Neurol. Sci. 481, 422-423. World Congress of Neurology (WCN 2017). https://doi.org/10.1016/j.jns.2017.08.3406.

• Kumar SP, Babu PP. NADPH Oxidase: a Possible Therapeutic Target for Cognitive Impairment in Experimental Cerebral Malaria. Mol Neurobiol 2022 Feb 59(2):800-820. doi:10.1007/s12035-021-02598-1
• Kumar SP, Babu PP. Aberrant Dopamine Receptor Signaling Plays Critical Role in the Impairment of Striatal Neurons in Experimental Cerebral Malaria. Mol Neurobiol 2020. doi:10.1007/s12035-020-02076-0
• Simhadri PK, Malwade R, Vanka R, Nakka VP, Kuppusamy G, Babu PP. Dysregulation of LIMK-1/cofilin-1 pathway: A possible basis for alteration of neuronal morphology in experimental cerebral malaria. Ann Neurol. 2017 Sep;82(3):429-443. doi: 10.1002/ana.25028.
• Vanka R, Nakka VP, Kumar SP, Baruah UK, Babu PP. Molecular targets in cerebral malaria for developing novel therapeutic strategies. Brain Res Bull. 2020 Apr; 157:100-107. doi:10.1016/j.brainresbull.2020.01.
• Nakka VP, Raghu G, Simhadri PK, Mohammed AQ, Babu PP. Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2α and XBP-1 pathways after stroke. Brain Res Bull. 2022 May;182:1-11. doi: 10.1016/j.brainresbull.2022.02.003.
• Narne P, Pandey V, Simhadri PK, Phanithi PB. Poly(ADP-ribose)polymerase-1 hyperactivation in neurodegenerative diseases: The death knell tolls for neurons. Semin Cell Dev Biol. 2017 Mar;63:154-166. doi: 10.1016/j.semcdb.2016.11.007.
• Vanka R, Kuppusamy G, Praveen Kumar S, Baruah UK, Karri VVSR, Pandey V, Babu PP. Ameliorating the in vivo antimalarial efficacy of artemether using nanostructured lipid carriers. J Microencapsul. 2018 Mar;35(2):121-136. doi: 10.1080/02652048.2018.1441915.
• Baruah UK, Gowthamarajan K, Ravisankar V, Karri VVSR, Simhadri PK, Singh V, Babu PP.Design, characterization and antimalarial efficacy of PEGylated galactosylated nano lipid carriers of primaquine phosphate. Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1809-1829. doi: 10.1080/21691401.2017.1394870.
• Baruah UK, Gowthamarajan K, Ravisankar V, Karri VVSR, Simhadri PK, Singh V. Optimisation of chloroquine phosphate loaded nanostructured lipid carriers using Box-Behnken design and its antimalarial efficacy. J Drug Target. 2018 Aug;26(7):576-591. doi: 10.1080/1061186X.2017.1390671.

• Prof.P.Prakash Babu, Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, Telangana, 500046, prakash@uohyd.ac.in, 9441583525
• Prof. N.Venkata Prasuja, Biochemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh, 522510, India, nvprasuja@gmail.com, 9949913760
• Prof. David Dietz, Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University of Buffalo, Buffalo, NY, 14203, ddietz@buffalo.edu, +18507661387

• Attended International Brain Research Organization (IBRO)-Associate School of Neuroscience on 'Recent Advances in Tools and Techniques in Neuroscience Research' held on 26-31 March, 2018 at Savitribai Phule University, Pune and presented a seminar on 'Aberrant activity of CDK5, hyperdopamine tone alters D1R/PKA/DARPP-32/PP1 pathway; a possible basis for dysregulation of NR2B, AMPA receptors and CaMKII proteins in experimental cerebral malaria.'
• Attended IBRO- Asia Pacific Regional Committee (APRC) School of Neuroscience - Epigenetic regulation of neuronal gene expression held on April 1-16, 2017 at Banaras Hindu University, Varanasi and presented a seminar on 'Altered neuronal morphology and dysregulation of LIMK-1/Cofilin-1 pathway in experimental cerebral malaria.'

• Received Gold medal for 1st rank and University fellowship during Masters in GITAM University 2011
• Received Department of Science and Technology (DST- INSPIRE) fellowship 2013-2018 (DST/INSPIRE Fellowship/2013/710)
• Received travel grant from the Department of Biotechnology (DBT)-CTEP travel grant 2017 (DBT/CTEP/02/201700810) to XX!V attend World Congress of Neurology, Japan
• Received Gold Medal for Young Scientist Award from Association of Biotechnology and Pharmacy in 2017
• Worked as a Summer Research Fellow (Indian National Science Academy) 2010 under the supervision of Dr. Amulya Kumar Panda, staff scientist, National Institute of Immunology, New Delhi, INDIA

• Kumar SP, Babu PP. NADPH Oxidase: a Possible Therapeutic Target for Cognitive Impairment in Experimental Cerebral Malaria. Mol Neurobiol 2022 Feb 59(2):800-820. doi:10.1007/s12035-021- 02598-1
• Kumar SP, Babu PP. Aberrant Dopamine Receptor Signaling Plays Critical Role in the Impairment of Striatal Neurons in Experimental Cerebral Malaria. Mol Neurobiol 2020. doi:10.1007/s12035-020- 02076-0
• Simhadri PK, Malwade R, Vanka R, Nakka VP, Kuppusamy G, Babu PP. Dysregulation of LIMK- 1/cofilin-1 pathway: A possible basis for alteration of neuronal morphology in experimental cerebral malaria. Ann Neurol. 2017 Sep;82(3):429-443. doi: 10.1002/ana.25028.
• Nakka VP, Raghu G, Simhadri PK, Mohammed AQ, Babu PP. Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2α and XBP-1 pathways after stroke. Brain Res Bull. 2022 May;182:1-11. doi: 10.1016/j.brainresbull.2022.02.003.
• Narne P, Pandey V, Simhadri PK, Phanithi PB. Poly(ADP-ribose)polymerase-1 hyperactivation in neurodegenerative diseases: The death knell tolls for neurons. Semin Cell Dev Biol. 2017 Mar;63:154-166. doi: 10.1016/j.semcdb.2016.11.007.
• Vanka R, Kuppusamy G, Praveen Kumar S, Baruah UK, Karri VVSR, Pandey V, Babu PP. Ameliorating the in vivo antimalarial efficacy of artemether using nanostructured lipid carriers. J Microencapsul. 2018 Mar;35(2):121-136. doi: 10.1080/02652048.2018.1441915.
   Baruah UK, Gowthamarajan K, Ravisankar V, Karri VVSR, Simhadri PK, Singh V, Babu PP.Design, characterization and antimalarial efficacy of PEGylated galactosylated nano lipid carriers of primaquine phosphate. Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1809-1829. doi: 10.1080/21691401.2017.1394870.
• Baruah UK, Gowthamarajan K, Ravisankar V, Karri VVSR, Simhadri PK, Singh V. Optimisation of chloroquine phosphate loaded nanostructured lipid carriers using Box-Behnken design and its antimalarial efficacy. J Drug Target. 2018 Aug;26(7):576-591. doi: 10.1080/1061186X.2017.1390671.