Sreeya Devarakonda

Motivated postgraduate degree holder of Research in Life Sciences . Detail-oriented and dedicated stem cells research enthusiast adept at prepping resources, equipment, and materials for research. Extensive background in investigating protein structural alterations with hands-on experience in laboratory work and advanced spectroscopic techniques .

Experienced in conducting thorough neurodegenerative disorders research through a published comprehensive review article on neurofilaments and analyzing data to support academic projects. Skilled in neuroscience and stem cells based research, cell culturing and photobiomodulation with notable contributions and academic achievements, reflecting on commitment and zeal for research.

Master's Dissertation | Jan 2024- July 2025

Project Title: Biochemical Investigations of Cellular and Standard Proteins using Light-Emitting Diode Induced Autofluorescence Spectroscopy (LED-IAF), Dept. of Biophysics, Manipal School of Life Sciences.

Objective: Led a comprehensive study to explore the effect of photobiomodulation on SH-SY5Y and HEK293 cellular protein topology by utilizing LED-IAF.

Practical Implications: Detection of protein biomarkers sensitive to photobiomodulation for pathophysiologic relevance of neuroblastoma cells in cancer research. Possible clinical relevance in identifying and characterizing protein biomarkers in neuroblastoma cells for ease of cancer detection using LED-IAF as a non-invasive procedure.

Conference Presentations: Presented findings at the Manipal Research Colloquium (MRC) 2024, Frontiers in Optics + Laser Sciences (FiO+LS, online) 2024, Optica, Denver, Colorado and The DAE-BRNS National Laser Symposium (NLS-33), 2025 showcasing innovative contributions to protein structural biology.

Master's Mini Project | Review Article Writing:

Comprehensive Literature Review: Conducted an in-depth analysis of Neurofilaments, covering its morphology, molecular mechanisms of alterations, and its efficacy in assessment of neurodegenerative disorders.
Publication: A review article titled 'Molecular mechanisms of neurofilament alterations and its applications in assessing neurodegenerative disorders' has been published in the journal Ageing Research Reviews, Elsevier (IF: 12.5, Q1 ranking) in Nov 2024.

• Highest Impact Factor review article published in MSLS (academic year 2024-25), Ageing Research Reviews, 12.5 IF, Q1 ranking.
• Best Poster award with cash prize at The National Laser Symposium (NLS-33), Indore.
• Merit Student Scholarship awardee for 2024 by Manipal School of Life Sciences.
• Other Scopus-indexed publications as part of the Optica conference proceedings.

• Review Article: (Published 8/11/24, Elsevier , Ageing Research Reviews )

Shanmukha Sreeya Devarakonda (†) , Basha, S (†), ... , & Mahato, K. K*. (2024). ”Molecular Mechanisms of Neurofilament Alterations and its Application in Assessing Neurodegenerative Disorders”. Ageing Research Reviews, 102566. (Impact Factor: 12.5; Q1, 98%)

• Research Article: ( Under review , Elsevier , Journal of Photochemistry and Photobiology, B: Biology, Manuscript ID: JPHOTOBIOL-D-25-00391)

Shanmukha Sreeya Devarakonda (†) , Basha, S (†) , ..., & Mahato, K. K*. (2024). ” Probing the Influence of Low-Level Laser Therapy on Cellular and Standard Proteins by Light Emitting Diode-Induced Autofluorescence Spectroscopy”.

(† Authors with equal contribution, * corresponding author)

Scopus Indexed Publications | Conference Proceedings:

• Devarakonda, S. S. ,Basha, S., Pithakumar, A., Thoshna, ..., Mahato, K. K*. (2024). Probing the Peroxynitrite-Induced Nitration of Proteins by Autofluorescence and FTIR Spectroscopy. Frontiers in Optics + Laser Science 2024 (FiO, LS).
• Thoshna, Basha, S., Pithakumar, A., Devarakonda, S. S., ..., & Mahato, K. K*. (2024). Probing the Influence of Heavy Metals on Protein Topology by Autofluorescence Spectroscopy. Frontiers in Optics + Laser Science 2024 (FiO, LS).
• Pithakumar, A., Basha, S., Devarakonda, S. S., Thoshna, ..., & Mahato, K. K*. (2024). Influence of Buffers on Intrinsically Disordered Proteins Using Autofluorescence Spectroscopy. Frontiers in Optics + Laser Science 2024 (FiO, LS).

Street Cause, Hyderabad | Student Coordinator (2022-2023)

• Coordinated student activities and events as part of Street Cause, the largest student run NGO in Hyderabad.
• Orchestrated student-led activities and events, boosting participant engagement rates substantially.

1. Dr. K.K. Mahato, Prof., Department of Biophysics, Manipal School of Life Sciences, Phone no: +919448836553, Email id: mahato.kk@manipal.edu

2. Dr. T.S Murali, Prof. and Head, Dept. of Public Health Genomics, Manipal School of Life Sciences, Phone no: +919741735278, Email id: murali.ts@manipal.edu