Srinivasa Rao Singuru

Dynamic, results-oriented professional with a strong background in research, eager to leverage skills and expertise in a challenging role. Committed to delivering tangible value to the organization while fostering personal and professional growth. A proactive approach to problem-solving and a passion for innovation drive the pursuit of excellence in every project. Prepared to contribute effectively to team objectives and support the organization's mission.

• Expertise in microbial and cell culture aseptic techniques.
• Participated in fermentation and related processes for seed production.
• Parameters optimization by pilot scale to large scale processes of fermentation.
• Process development and optimization of fermentation parameters like pH, Temperature, Agitation and DO and operation of batch fermentations at different scales.
• Trouble-shooting, optimization of industrial processes of fermentation technologies.
• Process development in fermentation including fermentor design and operation.
• Conduct routine maintenance of fermentor and industrial equipments.
• Execute small scale experiments supporting fermentation process development.
• Conduct detailed analysis, compiling and reporting of fermentation data.
• Perform fermentation sample for microbial and bio chemical analysis.
• Independently developed fermentation process for high cell growth and yield.
• Design and execution of production batches on market requirement.
• Actively participated in process improvement and process validation studies.
• Able to coordinate with vendors to meet user requirement specifications.

• Formulation of DTPHB-Hib group of vaccines.
• Responsible for monitoring of diphtheria, Tetanus and vaccine production as per market requirement.
• Maintenance of microbial cultures (seed banks) in separate facility.
• Monitoring of fermentation batches in blocks and preparation of URS for related equipments.
• Regular coordination with all inter functional teams respective to validation and calibration of all equipments in production blocks and maintaining the data for reference.
• Review of LPR, SOP’S, Process validation protocols and media simulation protocols.
• Responsible for implementing discrepancy management system, Change control, CAPA, Failure investigation, monitoring of production facility as per GMP standards.
• Document review of Batch Processing Record and all equipment log books as per standard operating procedure, Standard operating instruction.
• Conducting on job training in production block to create awareness about GMP operations.
• Actively participated in internal audit team.
• Analysis of Immunological Parameters.
• Analysis of Biochemical Parameters.
• Hormonal analysis.
• Analysis of Hematology Parameters.

• Initiation and investigation of incidents, root cause analysis.
• Handling of deviations, Change controls OOT/OOS and CAPAs.
• Verification of data integrity.
• Monitoring of online documentation of Quality control, Microbiology analysts and production designees.
• Frequently involving plant internal audits especially in production facility.
• Analytical lab tour for examination of all tests and analysis.

Overcoming the novel glycan–lectin checkpoints in tumor microenvironments for the success of the cross-presentation-based immunotherapy.

DOI: 10.1039/d4bm01732c