Motivated researcher with expertise in antimicrobial resistance and bacterial pathogenesis, seeking a postdoctoral position in antimicrobial resistance, bacterial virulence, host-pathogen interactions, or antimicrobial drug discovery. Experienced in dissecting molecular mechanisms underlying drug resistance and regulatory networks in pathogenic bacteria. Driven to advance fundamental and translational research in bacterial infection biology.
Hi, I’m
Suvendu Ojha
Bhubaneswar
Summary
Overview
6
years of professional experience
1
Certificate
Work History
BRIC-Institute of Life Sciences
Research Associate-I
09.2025 - Current
Job overview
Project: Pre-Clinical Validation of Montelukast-Moxifloxacin Combination Therapy for Multidrug-Resistant Staphylococcus aureus Sepsis.
- Conducting pre-clinical efficacy and PK/PD validation of Montelukast-Moxifloxacin combination therapy against MDR S. aureus, integrating clinical isolate screening and systemic murine sepsis models.
- Investigating mechanistic and immunomodulatory correlates of synergy, including efflux suppression, bacterial clearance, host inflammatory responses, and tissue drug exposure during systemic infection.
BRIC-Institute of Life Sciences
Junior/Senior Research Fellow
07.2019 - 09.2025
Job overview
Project: Targeting Efflux-Mediated Drug Resistance in S. aureus to Enhance the Therapeutic Potential of Existing Antibiotics.
- Identified FDA-approved drugs as efflux pump inhibitors that restore antibiotic susceptibility in multidrug-resistant S. aureus through drug repurposing strategies.
- Demonstrated synergistic antibiotic-adjuvant combinations that significantly reduced MICs and bacterial burden in vitro and in murine skin infection models.
- Elucidated mechanistic regulation of efflux systems, including MgrA-dependent transcriptional control and disruption of proton motive force to inhibit drug efflux.
Education
BRIC-Institute of Life SciencesBhubaneswar
Ph.D. from Biotechnology (Microbiology)
09-2025
University Overview
- Ph.D. supervisor: Dr. Tushar Kant Beuria
- Thesis title: Targeting Efflux-Mediated Drug Resistance in S. aureus to Enhance the Therapeutic Potential of Existing Antibiotics.
School of LIfe SciencesSambalpur
Master of Science from Botany
03-2018
University Overview
Specialization in Biochemistry
Udayanath Autonomous College of Science And TechnologyCuttack
Bachelor of Science from Botany
03-2016
University Overview
Certification
- National Workshop on Laboratory Animal Handling, Experimental Procedures, and in vivo Imaging, BRIC-Institute of Lifesciences, Bhubaneswar
- 4th Online International Flow Cytometry Course, Trust for Education and Training in Cytometry (TETC), India
- Essential Biostatistics for Biologists, Amazing Biotech Pvt. Ltd
- Basics of Computer Aided Drug Discovery, Udemy
Additional Information
Additional Information
Experimental Skills
- Microbiology Techniques: Biofilm assay, efflux assay, antimicrobial susceptibility testing (MIC, MBC, Time-Kill Kinetics, Checkerboard Assays), Microscopy (Fluorescence, Confocal, SEM).
- Molecular Biology Techniques: Gene Expression Analysis, Cloning and Protein Expression, Electrophoretic Mobility Shift Assay (EMSA).
- Biophysical and Biochemical Techniques: Protein Purification, Circular Dichroism Spectroscopy, Isothermal Titration Calorimetry, Protein-Drug Interaction (Fluorimetry).
- Cell Culture and Immunological Techniques: Mammalian Cell Culture, Short Tandem Repeat (STR) Profiling, Mycoplasma Testing, MTT Assay, Flow Cytometry (Bacterial viability and potential assay), Western Blot.
- Drug Discovery and Development Techniques: Standardization of Assay Systems to Screen Drug Libraries and Molecular Docking.
- Animal Model and Biosafety Techniques: Subcutaneous murine S. aureus skin infection model. I worked in both BSL2 and BSL3 facilities. Actively worked in COVID-19 testing in the biosafety level (BSL)-3 Laboratory.
- Statistical Analysis: Statistical analyses using GraphPad and Excel, including hypothesis testing, regression analysis, and data visualization. I have experience in power analysis to determine sample size for animal experiments.
Personal Skills
- Strong background in microbiology with expertise to work with Staphylococcus aureus.
- Proficient in experimental design, data collection, statistical analysis, and interpretation of results.
- Good scientific writing and communication skills demonstrated through peer-reviewed publications and conference presentations.
- Ability to work effectively in collaborative research environments and lead interdisciplinary teams.
- Strong organizational and time management skills, capable of handling multiple projects simultaneously.
Timeline
Research Associate-I
BRIC-Institute of Life Sciences
09.2025 - Current
Junior/Senior Research Fellow
BRIC-Institute of Life Sciences
07.2019 - 09.2025
BRIC-Institute of Life Sciences
Ph.D. from Biotechnology (Microbiology)
School of LIfe Sciences
Master of Science from Botany
Udayanath Autonomous College of Science And Technology
Bachelor of Science from Botany
Awards
Awards
- Council of Scientific and Industrial Research National Eligibility Test (CSIR-NET), Secured All India Rank 77 in the CSIR-NET research fellowship examination for pursuing a Ph.D., 08/01/19
- Graduate Aptitude Test in Engineering Life Science (GATE-Life Sciences), Secured All India Rank 745 in the GATE-Life Sciences for pursuing a Ph.D., 08/01/18
Patents
Patents
202431062787, A formulation to inhibit the growth of multidrug resistance S. aureus, pending, Suvendu Ojha, Dr. Tushar Kant Beuria
202531053455, Pharmaceutical compositions comprising sertaconazole or oxiconazole as efflux pump inhibitors for treating multidrug-resistant Staphylococcus aureus infections, pending, Suvendu Ojha, Dr. Tushar Kant Beuria
Publications
Publications
- Ojha, S., Sinsinwar, S., Chatterjee, P., Biswal, S., Pradhan, P., & Beuria, T. K. (2025). Efflux pump modulation by Montelukast and its roles in restoring antibiotic susceptibility in multidrug-resistant Staphylococcus aureus. EBioMedicine, 114, 105658. Advance online publication. https://doi.org/10.1016/j.ebiom.2025.105658
- Ojha S, Chatterjee P, Beuria TK. 0. Inhibition of efflux pumps by FDA-approved drugs oxiconazole and sertaconazole restores antibiotic susceptibility in multidrug-resistant S. aureus. Antimicrob Agents Chemother 0:e00320-25. https://doi.org/10.1128/aac.00320-25
- Dodia, H., Ojha, S., Chatterjee, P., & Beuria, T. K. (2025). 10058-F4 Mediated inhibition of the biofilm formation in multidrug-resistant Staphylococcus aureus. Biofilm, 10, 100307. https://doi.org/10.1016/j.bioflm.2025.100307 (Co-First Author)
- Ojha, S., & Beuria, T. K. (in press). Efflux-Mediated Resistance in Staphylococcus aureus: Challenges and opportunities for therapeutic intervention. Indian Journal of Microbiology.
Collaborations
Collaborations
- Shankar Das, B., Sarangi, A., Pahuja, I., Singh, V., Ojha, S., Giri, S., Bhaskar, A., & Bhattacharya, D. (2024). Thymol as Biofilm and Efflux Pump Inhibitor: A Dual-Action Approach to Combat Mycobacterium tuberculosis. Cell biochemistry and function, 42(8), e70030. https://doi.org/10.1002/cbf.70030
- Sarangi, A., Das, B. S., Pahuja, I., Ojha, S., Singh, V., Giri, S., Bhaskar, A., & Bhattacharya, D. (2024). Ajoene: a natural compound with enhanced antimycobacterial and antibiofilm properties mediated by efflux pump modulation and ROS generation against M. Smegmatis. Archives of microbiology, 206(12), 453. https://doi.org/10.1007/s00203-024-04189-9
- Anas, M., Ghosh, S., Ojha, S., Beuria, T. K., & Das, S. (2025). Ion-Induced modulation of Amoeba-Bacteria interactions in wastewater: insights from experimental data and machine learning validation. Agricultural Water Management. (Under Review)
Poster Presentations
Poster Presentations
- Targeting Efflux Machinery to Combat Antimicrobial Resistance, Suvendu Ojha, Tushar Kant Beuria, 3rd International Conference on Antimicrobial Resistance, Novel Drug Discovery and Vaccine Development: Opportunities, SRM University, Delhi-NCR, Sonepat, 03/18/24, 03/20/24
- Targeting Efflux Machinery to Combat Antimicrobial Resistance, Suvendu Ojha, Tushar Kant Beuria, Quarterly Union for Academic Discourse (QUAD) mini symposium, ILS, Bhubaneswar, 04/27/24
- Targeting Efflux Machinery to Combat Antimicrobial Resistance, Suvendu Ojha, Tushar Kant Beuria, Scientific Advisory Committee Meeting, ILS, Bhubaneswar, 02/01/23
References
References
Dr. Tushar Kant Beuria (Ph.D. Supervisor)
Scientist-F, Bacterial Cell Division and Antimicrobial Resistance Lab
BRIC-Institute of Life Sciences
Bhubaneswar, India- 751023
Email: tkbeuria@ils.res.in; tkbeuria@gmail.com
Dr. Narottam Acharya (Scientific Advisor)
Scientist G, Genome Instability Laboratory
BRIC-Institute of Life Sciences
Bhubaneswar, India-751023
Email: narottam_acharya@ils.res.in
Dr. Soma Chattopadhyay (Doctoral Advisory Committee Member)
Scientist F, Molecular Virology Laboratory
BRIC-Institute of Life Sciences
Bhubaneswar, India-751023
Email: soma@ils.res.in