Swayangsiddha Goswami
Bengaluru
Overview
3
3
years of professional experience
Work History
Research Intern
Dr. Kavita Babu, Centre for Neurosciences, IISc, Bengaluru
Bengaluru
05.2023 - 12.2023
- Conducted genome editing using CRISPR-Cas9 in primary cell culture systems including N2A and neuron cultures.
- Maintained C. elegans mutant plates generated through CRISPR-Cas9 editing techniques.
- Investigated neuropeptide flp-15's role in regulating locomotion in C. elegans.
- Examined neurodegenerative disorders, including Alzheimer's, utilizing EEG-based research methods.
Computational modelling of test datasets during
Rajesh Sundaresan, Division of Electronics and Computer Science, IISc, Bengaluru
Bengaluru
01.2024 - 05.2024
- Developed digital smart-city models to study disease progression and serosurvey dynamics.
- Predicted future disease burden using real-world datasets, applying SEIR modeling and maximum likelihood estimation.
2024 Integrated Disease Surveillance Program
Dr Agnihotri Bhattacharyya, Medical Superintendent-cum-Vice Principal, SCCGMCH, Howrah
Howrah
05.2024 - 08.2024
- Conducted blood cultures for typhoid, stool cultures for cholera, and ELISA assays for hepatitis.
- Collected, compiled, and analyzed weekly surveillance data on epidemic-prone diseases.
- Contributed to the design of effective public health programs targeting vector-borne diseases.
- Engaged in research on autoimmunity and chronic immune-mediated disorders, including Crohn’s disease, and ulcerative colitis.
Research Intern
Dr. Mahavir Singh, Molecular Biophysics Unit, IISc, Bengaluru
Bengaluru
08.2024 - 04.2025
- Analyzed the assembly of bacterial type III toxin–antitoxin (TA) complexes.
- Investigated the pseudoknot antitoxin structure in a novel AvcID TA system of Vibrio cholerae.
- Compared activation of HigBA and ToxN TA systems in E. coli.
- Explored bacterial stress response and quorum-sensing mechanisms.
- Applied computational protein modeling with AlphaFold and Swiss-Prot, leveraging NCBI and PDB databases.
Ecological statistical analysis project with data
Dr. Kartik Shankar, Centre for Ecological Sciences, IISc, Bengaluru,
Bengaluru
11.2024 - 12.2024
- Constructed phylogenetic trees with Poecilia species, based on morphology and gene homology.
- Investigated associative learning in fish using operant conditioning cues.
- Data collection, capturing, measuring, and tagging animals were done.
Summer Internship as a Charpak Fellow at École Pol
Professor Alexis GAUTREAU, Chair BIOC, Laboratory of Structural Biology of the Cell
Paris
05.2025 - 08.2025
- Investigated the polymerization of trans-apical actin fiber networks within epithelial monolayers to understand their role in regulating the persistence of cell migration.
- Employed confocal and live-cell microscopy (Leica LAS X system) to capture dynamic images of collective cell migration.
- Extensively utilized Fiji and ImageJ plugins such as OrientationJ to determine fiber orientation.
- Applied tracking and cell segmentation to correlate nuclear trajectories with fiber orientations.
- Utilized molecular biology techniques including western blotting, plasmid transfection, protein purification, and fluorophore tagging.
- Applied Particle Image Velocimetry (PIV) and Traction Force Microscopy to analyze cellular dynamics.
WEHI InSPIRE Asia Scholar (2025) at Walter and E
Professor Vihanda Wickramasinghe, Genetics and Gene Regulation Division, WEHI
Melbourne
08.2025 - 11.2025
- Utilized fluorescence in situ hybridization technique to observe formation of nuclear speckles in tumor cells following drug treatment.
- Used RNAi-based editing techniques to mutate proteins involved in mRNA export.
- Cultured iPSCs and differentiated them.
- Performed fluorescence activated cell sorting with variable gating.
Dissertation Project for Bachelor of Science Degr
Dr. Kavita Babu, Centre for Neurosciences, IISc, Bengaluru
Bengaluru
11.2025 - Current
- worked extensively with the nematode model system C.elegans
- Performed CRISPR-Cas9 based editing to obtain flp-33, mutant worm.
- Tracked worm locomotion under both on and off-food condition with MBF WormLab system and a Zeiss Stemi 2000-C stereoscope.
- Performed exogenous monoamine supplementation assays.
- Utlized molecular cloning techniques to rescue mutant worms and observe flp-33 expression patterns in dopaminergic neurons.
Education
Bachelor of Science (Research) - Biological Sciences Major, Bioengineering Minor
Indian Institute of Science
Bengaluru, India07-2026
Higher Secondary Education -
BDM International
Kolkata, India10-2021
Secondary Education -
The Future Foundation School
Kolkata, India05-2019
Skills
- Programming Languages: Python, R, C,Java, Linux Command line, MATLAB
- Protein Modelling: AlphaFold 20, Rosetta Fold, SwissProt, DALI Server
- Nucleic Acid Modelling: Mfold, RNAfold, SHAPE
- Databases Handled: UniProt, PDB, ClinVar (NCBI), CGC, WormBase
- Bioimaging: BioImageXD, Cell Profiler, Fiji (ImageJ), TrackMate
- Analyzing tools for epitope-paratope interactions: PyMOL, Chimera & ChimeraX, AbPredict
- CRISPR & Genomic Editing: CHOPCHOP, CrisprScan
- Transcriptome Analysis: Bio-Rad CFX Manager, FastQC, Galaxy
- Scientific presentation: Bio Render
- Image Analysis: ImageJ
- Biogeographic and Species Distribution Modelling: QGIS, Maxent
- Protein-Ligand Docking: PyMol, AlphaFold
- Statistical analysis of large-scale data: SPSS, R, ANOVA
Laboratory Skills
• PCR Amplification, q-PCR, RT-PCR.
• Genomic Library Preparation.
• Nucleic Acid Sequencing (Sanger sequencing, Illumina, Deep sequencing, Oxford-Nanopore sequencing).
• Chromatin Immunoprecipitation, ELISA.
• Genome Editing (Base Editing & Prime Editing, RNAi, CRISPR-Cas9, CRISPRa & CRISPRi).
• Fluorescence in situ Hybridization, Immunofluorescence Studies, Fluorescence Recovery After Photobleaching..
• LC-Mass Spectrometry, Isothermal Calorimetry.
• Super resolution microscopy: Conocal, White Film and Live-cell Imaging.
• Flow Cytometry, Fluorescence Activated Cell Sorting
• DNA extraction, transformation, purification, SHAPE-based probing, and cloning.
• Primary Cell Cultures and iPSC cultures.
• ELISA, Gel Electrophoresis, and Mutant Screening.
• Western blotting, Restriction Digestion, Gel Electrophoresis, DNA Ligation.
• NMR, UV Spectroscopy, and Circular Dichroism Spectroscopy.
• Protein and RNA purification techniques like Size Exclusion Chromatography or Affinity Chromatography.
• Particle Image velocimetry, Traction force Microscopy.
• Animal Handling & Behavioral Analyses: Drosophila, C.elegans, rodents, ants, fishes.
Publications
Review article: “Comparative transcriptomic profiling of claudin genes across vertebrate phyla”
Under the guidance of Professor Kavita Babu, Centre for Neuroscience, IISc
Manuscript number (BBRC-26-423), submitted in Biochemical and Biophysical Research Communications, Elsevier.
Technical study on 'Knowledge and Practice of Standard Precautions and Awareness Regarding
Laboratory safety among undergraduate college students from Bengaluru, India
Manuscript submitted to 'Indian Journal on Preventive and Social Medicine'
Workshop Attended
- Attended a workshop on mass spectrometry as part of the course Multi-omics Approaches in Biology.
- Attended a winter school organized by IISER Berhampur consisting of several lectures on translational research in regenerative medicine.
- Attended a guest lecture on "Tumor and Stem Cell-derived Organoids as a Powerful Platform for Translational Cancer Research" by Dr. Senthil K Muthuswamy, National Cancer Institute, MD,USA.
- Attended a guest Lecture on “Stem, Stroma, and Beyond: The Crossroads of Regenerative Medicine in Radiation Biology” by Dr. Subhrajit Saha, Department of Radiation Oncology, University of Kansas Medical Center.
- Attended CATs, the annual in-house symposium of the Centre for Ecological Sciences at IISc.
Extracurricular Activities
- Gosoku Ryu Karate-Do black belt, 2018
- Khelo India Intern under the Sports Authority of India (Sep 2015 - Feb 2016)
- District-level gold medalist in open water swimming, 2014
Affiliations
Volunteer at Princeton Foundation, participated in the " 2025 National HPV vaccine distribution Drive for Elimination of Cervical Cancer"
Accomplishments
2019 Jagadish Bose National Talent Search Scholar.
Languages
English (TOEFL: 114/120), Hindi, Bengali (Mother Tongue), French
Timeline
Dissertation Project for Bachelor of Science Degr
Dr. Kavita Babu, Centre for Neurosciences, IISc, Bengaluru
11.2025 - Current
WEHI InSPIRE Asia Scholar (2025) at Walter and E
Professor Vihanda Wickramasinghe, Genetics and Gene Regulation Division, WEHI
08.2025 - 11.2025
Summer Internship as a Charpak Fellow at École Pol
Professor Alexis GAUTREAU, Chair BIOC, Laboratory of Structural Biology of the Cell
05.2025 - 08.2025
Ecological statistical analysis project with data
Dr. Kartik Shankar, Centre for Ecological Sciences, IISc, Bengaluru,
11.2024 - 12.2024
Research Intern
Dr. Mahavir Singh, Molecular Biophysics Unit, IISc, Bengaluru
08.2024 - 04.2025
2024 Integrated Disease Surveillance Program
Dr Agnihotri Bhattacharyya, Medical Superintendent-cum-Vice Principal, SCCGMCH, Howrah
05.2024 - 08.2024
Computational modelling of test datasets during
Rajesh Sundaresan, Division of Electronics and Computer Science, IISc, Bengaluru
01.2024 - 05.2024
Research Intern
Dr. Kavita Babu, Centre for Neurosciences, IISc, Bengaluru
05.2023 - 12.2023
Bachelor of Science (Research) - Biological Sciences Major, Bioengineering Minor
Indian Institute of Science
Higher Secondary Education -
BDM International
Secondary Education -
The Future Foundation School