Venkatraman Ananthakrishnan

As a recent graduate with an MPharm degree specializing in Pharmacology, I am passionate about securing a position within your esteemed organization. I possess a comprehensive understanding of drug mechanisms, interactions, and their impact on biological systems. Proficient in conducting research, analyzing data, and interpreting results, I have honed skills in pharmacokinetics, pharmacodynamics, and drug development. With a strong academic foundation and practical experience gained through coursework and projects, I am adept at critical thinking and problem-solving within the realm of pharmaceutical sciences. Eager to contribute my knowledge and enthusiasm to a dynamic team, I am poised to embark on a fulfilling career in the field of pharmacology to derive impactful outcomes.

Cardioprotective Effect of Hydroalcoholic Root Extract of Althaea Officinalis Linn against Isoproterenol Induced Myocardial Infarction in Wistar Rats.

Research Description:

1. In Silico Docking Studies:

• Conducted in silico docking studies using Autodock 4.2.1 software.
• Predicted ligand interactions with biological macromolecular targets.
• This computational approach provided insights into the potential molecular mechanisms and binding affinities of the hydroalcoholic root extract compounds with specific targets related to myocardial infarction.
  

2. In Vitro, In Vivo, and Ex Vivo Studies:

• Performed in vitro, in vivo, and ex vivo studies using the isoproterenol-induced myocardial infarction model in Wistar rats.
• In vitro studies involved testing the effects of the extract on cardiac cells or tissues.
• In vivo studies were conducted on live animals, administering the extract to observe its effects on the development and progression of myocardial infarction.
• Ex vivo studies analyzed the extract's effects on heart tissue samples taken from the rats.
  

3. Outcome:

• Treatment with hydroalcoholic root extract of Althaea Officinalis Linn demonstrated a significant reduction in the extent of myocardial infarction.
• Improved cardiac function and parameters related to heart health.
• This suggests the potential of the extract as a therapeutic agent for myocardial infarction.
• Results were analyzed using statistical methods to ensure robustness and reliability.
• The findings provide valuable insights into the cardioprotective properties of the hydroalcoholic root extract.
  

This comprehensive approach, from computational modeling to experimental validation, offers a thorough investigation into the potential therapeutic benefits of the hydroalcoholic root extract of Althaea Officinalis Linn in the context of myocardial infarction.

Method Development and Validation for Estimation of Lamivudine in Bulk and Plasma using UV Spectrophotometry

Research Description:

1. Development of UV-visible Spectroscopic Methods:

• Developed novel UV-visible spectroscopic methods specifically for the estimation of Lamivudine.
• These methods were tailored for the analysis of Lamivudine in both bulk and plasma samples.
• Utilized UV, first and second order derivatives spectrophotometric techniques for enhanced sensitivity and accuracy.
  

2. Identification of Absorbance Wavelength:

• Determined the wavelength of maximum absorbance for Lamivudine to be 272nm.
• This specific wavelength exhibited a strong correlation between Lamivudine concentration and the corresponding absorbance values.
• The identified wavelength of 272nm is crucial for establishing accurate pharmacokinetic studies of Lamivudine.
  

3. Outcome:

• The developed UV-visible spectroscopic methods demonstrated:High sensitivity and specificity in detecting Lamivudine in both bulk and plasma samples.
• Good correlation between Lamivudine concentration and absorbance values at 272nm.
• These methods are vital for precise quantification of Lamivudine levels, aiding in drug formulation and dosage determination.
• The validated methods ensure compliance with regulatory standards, enhancing their utility in pharmaceutical analysis.
  

This research contributes to the advancement of analytical techniques for the estimation of Lamivudine, particularly in bulk and plasma samples. The identified wavelength and developed methods provide a reliable means for quantifying Lamivudine levels, which is essential for pharmacokinetic studies and pharmaceutical applications.

• Attended International conference on Professional Development and Advanced Training in Artificial Intelligence driven drug design, discovery and development held at JSS College of Pharmacy, Ooty
• Participated in e-poster presentation at international conference on Professional Development and Advanced Training in Artificial Intelligence driven drug design, discovery and development held at JSS College of Pharmacy, Ooty
• Attended webinar on the topic “Importance of clinical pharmacology in drug development” conducted by Indian Pharmaceutical Association- Student's Forum (IPA-SF)
• Participated and poster presentation was done at 11th international conference of the Laboratory Animal Scientists Association (LASA) on “Advancement of 3R’s in Biomedical research, Laboratory animal science and welfare, international perspectives”.