Vivek R
Bengaluru
Summary
DSP scientist with a robust background at Syngene International and a PhD from IIT Madras. Specializing in late-stage process development for monoclonal antibodies and technology transfer. Skilled in continuous chromatography and protein refolding, with a strong ability in scientific writing. Proven mentorship abilities, enhancing team capabilities, and driving innovative solutions in biopharmaceuticals
Overview
11
11
years of professional experience
Work History
Research Investigator
Syngene International
07.2023 - Current
· Carried out late-stage process development for novel bispecific fusion monoclonal antibodies (mAbs).
· Executed the scale-up and technology transfer of the DSP process from laboratory scale to 2KL GMP production.
· Authored and reviewed protocols, technical reports, tech transfer documents (TTD), and batch manufacturing records (BMR).
· Spearheaded technical discussions on recent advancements and updates in DSP
PhD Thesis
IIT Madras
01.2016 - 05.2023
- Designed and implemented an operational strategy for IMAC-based continuous matrix-assisted refolding of inclusion bodies using periodic counter-current chromatography.
- Developed a two-stage process for high-throughput continuous refolding and purification of inclusion bodies utilizing SEC and IMAC chromatography.
- Authored and published research findings in relevant scientific journals.
- Isolated HPLC-grade pure beta-lactoglobulin isoform (B-LGB) from a mixture of LGB A and LGB B isoforms through ion-exchange chromatography (Industry project)
- Provided mentorship to junior scholars and project students, offering guidance on research and academic development
Junior Research Fellow
IIT Madras
10.2015 - 12.2015
- Carried out high cell density cultivation of Pichia pastoris using a perfusion system to optimize recombinant protein production
M.Tech Thesis
IIT Madras
06.2014 - 05.2015
- Developed an aqueous two-phase system combined with diafiltration for the purification of hyaluronic acid from recombinant Lactococcus lactis
Education
Ph.D. - Biotechnology
IIT Madras
Chennai, India05-2023
M.Tech - Industrial Biotechnology
Manipal Institute of Technology
Manipal, India05-2015
B.E - Biotechnology
New Horizon College of Engineering
Bengaluru, India05-2013
Skills
- FPLC (AKTA PCC, AKTA pure, and AKTA prime plus)
- Continuous chromatography
- Protein refolding
- HPLC
- Ultrafiltration
- Depth Filtration
- Bioreactor (Bioengineering, Biojenik, and Infors)
- MATLAB
- Scientific writing
- Experimental design
Publications
- 1. V. Rajendran, Ananthi Ponnusamy, S. Pushpavanam, G. Jayaraman, Continuous refolding and purification by two-stage periodic counter-current chromatography, J.Chromatography. A.1695 (2023)
- 2. V. Rajendran, S. Pushpavanam, G. Jayaraman, Continuous refolding of L-asparaginase inclusion bodies using periodic counter-current chromatography, J. Chromatography. A.1662 (2022)
- 3. A. Ashokan, V. Rajendran, T.S. Sampath Kumar, G. Jayaraman, Eggshell derived hydroxyapatite microspheres for chromatographic applications by a novel dissolution - precipitation method, Ceram. Int. (2021)
- 4. V. Rajendran, K. Puvendran, B.R. Guru, G. Jayaraman, Design of aqueous two-phase systems for purification of hyaluronic acid produced by metabolically engineered Lactococcus lactis, J. Sep. Sci. (2016)
Workshops and Training
1. COE-CBT lecture series on Downstream processing at IIT Delhi (2024)
2. I-incubate Bootcamp on accelerating start-up ideas conducted by Gopalakrishnan Deshpande Center for Innovation, IIT Madras (2019)
3. “Intensify your continuous downstream processing” workshop on continuous chromatography conducted by Cytiva and IITM Bio incubator (2017)
4. “Downstream processing for separation of proteins and macromolecules” at IIT Madras (2015).
ORGANISATIONAL RESPONSIBILITIES
- Research legislator for the Department of Biotechnology, IIT Madras (2018-2019).
- Coordinator for biotech technical fest “BIOFEST” and cultural fest “Sargam” at New Horizon College of Engineering, India (2012-13).
References
P r o f. G u h a n J a y a r a m a n
IIT-Madras
E: guhanj@iitm.ac.in
P r o f. S P u s h p a v a n a m
IIT-Madras
E: spush@iitm.ac.in
P r o f. B h a r a t h R a j a G u r u
Manipal Institute of Technology E: bharath.guru@manipal.edu
Timeline
Research Investigator
Syngene International
07.2023 - Current
PhD Thesis
IIT Madras
01.2016 - 05.2023
Junior Research Fellow
IIT Madras
10.2015 - 12.2015
M.Tech Thesis
IIT Madras
06.2014 - 05.2015
Ph.D. - Biotechnology
IIT Madras
M.Tech - Industrial Biotechnology
Manipal Institute of Technology
B.E - Biotechnology
New Horizon College of Engineering
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