Aakash Mondal

Committed job seeker with a history of meeting company needs with consistent and organized practices. Skilled in working under pressure and adapting to new situations and challenges to best enhance the organizational brand.

Evaluation Parameters of Formulations, Quality Control

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Formulation and Evaluation of Sublingual Films of Prednisolone, Prednisolone is BCS class I drug. The main objective of the study was to develop Sublingual Film of Prednisolone with the hydrophilic polymers. The main objectives of this study to develop Sublingual Film of Prednisolone by solvent casting method using PEG and PVP as Polymer. FTIR study was carried out to identify any drug polymers interaction showed that the physical mixture was compatible with each other. Prepared films were evaluated various physicochemical properties and from the results it was concluded that Ethyl Cellulose was having better film forming capacity and appropriate drug release profile as compared to PEG. Formulation F2 (300 mg Ethyl Cellulose and 3 mg SSG) was optimized which showed minimum disintegration time of 33 ± 1.5 secs, % CDR 99.16 % in just 12 mins. Further stability study of this optimized batch was carried for 1 months at 40C ± 2C and 75% ± 5% RH and after 1 months it was evaluated for different parameters, which suggested that the formulation F2 was stable for the period of 1 months as there are no significant changes in the properties of the films. From the whole study it was concluded that Sublingual Film of Prednisolone is an acceptable dosage form which suggests that it is likely to become one of the choices of Prednisolone preparations for the treatment of Bronchial Asthma.