Anil Rathod
Bengaluru
Summary
I have expertise as an In-vitro ADME DMPK Scientist in the field of drug discovery and development, possessing strong knowledge of drug metabolism, pharmacokinetics, and biological assays. I am skilled in improving research accuracy and precision and am dedicated to executing protocols to meet study objectives and requirements. I am eager to collaborate with top talent and be part of a team that excels in technological innovation.
Overview
5
5
years of professional experience
1
1
Certification
Work History
Research Associate
Biocon-Bristol Myers Squibb research Centre
Bengaluru
10.2023 - Current
- Experienced in performing In-vitro ADME inhibition studies like CYP inhibition, IC50, CYP TDI, Mechanism based CYP inhibition (MBI) Ki/ Kinact for preclinical drug candidates in drug discovery and development.
- Involved and developed new assays like human CES-1 and human CES-2 and Phynotyping assay.
- Carrying out in-vitro UGT inhibition studies.
- Prepared detailed reports summarizing experimental findings.
- Designed new experiments based on previous work or existing literature reviews.
Senior Research Associate
Biocon-Bristol Myers Squibb research Centre
Bengaluru
03.2022 - 09.2023
- Conducted in-vitro ADME studies of drug metabolism and pharmacokinetics study and In-vitro assay involving preclinical drug development.
- Carrying out in-vitro studies UGT inhibition, Blood to plasma ratio, Blood stability, plasma stability.
- Carrying out plasma protein binding study (PPB) and other tissue binding studies like Brain binding, tumor binding, lung and heart tissue binding.
- Experience in thawing hepatocytes, performing in-vitro metabolic stability studies using hepatocytes and other tissue fractions.
- Predicting in-vitro clint and IVIVE by using hepatocyte and microsome stability data.
Senior Scientific Assistant
Cadila Healthcare Limited (Zydus Research Centre)
Ahmedabad
01.2019 - 02.2022
- Responsible for carry out studies like CYP inhibition, IC50, TDI and IC50 shift.
- Hands on mammalian cell culture, passaging and propagation techniques. Media preparation and cell line maintenance.
- Experienced in performing in-vitro permeability and transporters assay’s using Caco2, MDCK, HEK293 cell lines.
- Carrying out plasma protein binding study (PPB), metabolic stability using microsomes, hepatocytes and other liver fractions.
- Develop the UPLC method for the small molecules, prepare and analyze samples of Aq. Solubility, Log-D by using UPLC, excellent knowledge and handling experience of HPLC chromatographic method development.
Education
Master of Pharmacy - (Pharmacology And Toxicology)
Bombay College of Pharmacy
Mumbai01-2019
Bachelor's of Pharmacy - Pharmaceutical Sciences
Sinhgad Institute of Pharmaceuatical Sciences
Pune 06-2016
Skills
- Hardworking
- Enthusiastic
- Decision maker
- Good communication skill
- Team player
- Protocol development
Certification
- Completed "one-week training on handling of Zebra-fish‟ at Central Institute of Fisheries
Sciences, Versova, Mumbai. - Completed DMPK International Society for the Study of Xenobiotics (ISSX) 2022 certification course organized by ISSX.
Accomplishments
- Awarded with, „Excellence Award‟ for demonstrating the spirit of eminence in execution
at Zydus Research Center.
Publications
- Giri, P. et al. ZY12201: A Potent TGR5 Agonist: Identification of a Novel Pan CYP450 Inhibitor Tool Compound for In-Vitro Assessment. Drug Metabolism and Bioanalysis Letters 15, 116–132 (2022).
Timeline
Research Associate
Biocon-Bristol Myers Squibb research Centre
10.2023 - Current
Senior Research Associate
Biocon-Bristol Myers Squibb research Centre
03.2022 - 09.2023
Senior Scientific Assistant
Cadila Healthcare Limited (Zydus Research Centre)
01.2019 - 02.2022
Master of Pharmacy - (Pharmacology And Toxicology)
Bombay College of Pharmacy
Bachelor's of Pharmacy - Pharmaceutical Sciences
Sinhgad Institute of Pharmaceuatical Sciences
- Completed "one-week training on handling of Zebra-fish‟ at Central Institute of Fisheries
Sciences, Versova, Mumbai. - Completed DMPK International Society for the Study of Xenobiotics (ISSX) 2022 certification course organized by ISSX.
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