Dolly Sharma

Sincere, dedicated and skilled research scholar in Amity Institute of Biotechnology, Amity University, Noida. Elaborate experience in Drug Design and Synthesis centric research focused on synthesis and anticancer activity of biorelevant small molecules targeted against G-Quadraplex, tumor glycolysis and hLDH evidenced by my research publications and submitted patents. I bring experience in both self-directed and support research capacities, as well as M. Tech degree in Biotechnology from School of Biotechnology, Gautam Buddha University. Currently working in the field of Target- and Fragment- based drug discovery, bio-relevant small molecules and their biological activity assay and cancer cell metabolism.

Patent filed:

· 1 full patent filed

Reshma Rani, Vinit Kumar, Dolly Sharma filed patent on, “Flourine modified phenoxybenzene based small molecules inhibitors of lactate dehydrogenase (LDH) and method.

Provisional application number: 20201104243020

Full patent filed: 3rd December, 2021

Research articles (accepted for publication)

· Dolly Sharma, Vinit Kumar, Reshma Rani. Design, synthesis, in silico ADMET profiling of pseudo-pyrimidine derivatives and anticancer activity evaluation. Research Journal of Science and Chemistry

· Dolly Sharma, Mamta Singh, Jayadev Joshi, Manoj Garg, Vidhi Chaudhary, Daniel Blankenberg, Sudhir Chandna, Vinit Kumar, Reshma Rani. Design and synthesis of thiazole scaffold-based small molecules as anticancer agents targeting human lactate dehydrogenase A enzyme. Royal Society of Chemistry.

Review articles (accepted for publication)

· Dolly Sharma, Mamta Singh, Sweta Verma, Manoj Garg, Andrea Altieri, Alexander V. Kurkin, Vinit Kumar, Reshma Rani. Targeting Virus-Induced Reprogrammed Cell Metabolism via Glycolytic inhibitors: an effective therapeutic approach against SARS-CoV-2. Mini-Reviews in Medicinal Chemistry

· Dolly Sharma, Mamta Singh, Vivek Kumar, Rajat Gupta, Vinit Kumar, Reshma Rani. Intervention on Lactate: An effective approach in cancer therapeutics. Advances in Cancer Biology - Metastasis

Review articles (under investigation)

· Mamta Singh, Dolly Sharma, Manoj Garg, Ankur Baliyan, Vinit Kumar, Reshma Rani. Current understanding of Biological Interactions and Processing of DNA Origami Nanostructures: Role of Machine Learning and Implications in Drug Delivery. Biotechnological Advances

· Dolly Sharma, Mamta Singh, Vinit Kumar, Reshma Rani. Impact of Natural antioxidants on hypothyroidism: Current Status and Future Prospects of Herbal Remedies and Natural antioxidants. Medicinal Research Reviews

· Dolly Sharma, Mamta Singh, Vinit Kumar, Reshma Rani. RNA G-Quadruplexes: A hope for effective therapeutics in cancer and viral diseases. Current Chemical Biology

· Dolly Sharma, Mamta Singh, Manoj Garg, Andrea Altieri, Alexander Kurkin, Vinit Kumar, Reshma Rani. Energy disruption via Glycolytic Inhibitors: An Effective Therapeutic Approach Against SARS-CoV-2. Current Research in Virological Science

Book Chapter Published

· Atul Kumar, Mamta Singh, Dolly Sharma, Vinit Kumar, Reshma Rani. Tumor Metabolism: Focussed on Tumor Glycolysis, Progress and Prospects in Cancer Therapy. Burger’s Medicinal Chemistry, Drug Discovery and Development, Eighth Edition. DOI: 10.1002/0471266949.bmc286

Technical skills

· Excellent knowledge of basic and advance organic chemistry functional group conversion and multiple step synthesis

· Experienced in animal handling

· Good knowledge of TLC, column purification and extraction

· Good knowledge in computer (MS-word/Excel/Power point) and structure drawing (Chem Draw/Chem Sketch)

· Experienced in data mining and literature survey using Sci Finder, SWISS-PROT

· Multi-tasking (i. e. good in chemical cataloguing, ordering and maintaining lab inventory)

• Dr. Reshma Rani

Team Leader

Drug Discovery Unit

Jubilant Biosys

Greater Noida, Uttar Pradesh 201303, India

Phone: 7536843982

Email: reshudcy@gmail.com,

• Dr. Vinit Kumar

Assistant Professor

Amity Institute of Molecular Medicine and Stem Cell Research

Amity University, Noida, UP, India

Phone No. +91-9758118300

Email : vkumar@iitr@gmail.com

• Dr. Sudhir Chandna

Sci.’G’ and Additional Director

Head of Division: Natural Radiation Response Mechanisms

Institute of Nuclear Medicine and Allied Sciences, DRDO, Timarpur, Delhi

Phone No. +91-9871098714

Email : sudhirchandna@yahoo.com

• Dr. Bhaswati Banerjee

Assistant Professor

School of Biotechnology

Gautam Buddha University Greater Noida, UP, India

Mobile; +91-9810093043

E-mail: bhaswati@gbu.ac.in