Dr. SRIPARNA DAS, PhD

• Driven researcher exploring innate immune response, macrophage function, immunometabolic reprogramming, hepatic inflammation, endocrine disruption and metabolic disorders. My doctoral research investigates immunometabolic alterations, with a particular focus on estrogenic and xenoestrogenic regulation of macrophage polarization and hepatic metabolism in murine models. I have delineated the mechanistic interplay between endocrine signaling, immune function, redox imbalance, and inflammatory reprogramming, emphasizing the involvement of NF-κB/NLRP3 and prostaglandin pathway, HIF1α, and SIRT1/AMPK/PGC1a circuitry in BPA-induced hepatic steatosis (NAFLD) and metabolic dysregulation. Furthermore, my work demonstrates that antioxidant supplementation (N-acetyl Cysteine) and targeted inhibition of the NF-κB/NLRP3 axis effectively restore metabolic homeostasis. In addition, I have contributed to interdisciplinary projects on platinum-based anticancer agents in human adenocarcinoma cells (A549), fluorescent redox probes, and endocrine toxicity in aquatic models. Offering strong analytical and problem solving skills gained through rigorous doctoral research. Knowledgeable about data analysis, critical thinking, effective communication and constantly been enthusiastic in immunology research.
• Curated research article in Comparative Toxicogenomics Database (CTD). https://ctdbase.org/detail.go?type=reference&acc=39260547 in the disease-section of fatty liver disease.

• Sudipta, Maitra, Professor, sudipta.maitra@visva-bharati.ac.in, +919874405555, Visva-Bharati University
• Susanta, Roychowdhury, Senior Principal Scientist, susanta@iicb.res.in, susanta_rc@yahoo.co.in, ICMR Emeritus Scientists, Indian Institute of Chemical Biology, Molecular & Human Genetics Division
• Gaurisankar, Sa, PhD,FNASc,FNA(Sg),FAScT, gauri@jcbose.ac.in, gaurisankarsa@yahoo.com, +91-33-2569-3146, +91 98300-17107, ICMR Emeritus Scientists, Former NASI Platinum Jubilee Senior Professor, Ex-Chairman of Molecular Medicine, Bose Institute, Division of Molecular Medicine, Fax: +91-33-2355-3886

Innate immune response, Immune cell function, Macrophage biology, Metabolic Regulation, Cancer, Inflammation, Mitochondrial Function, Immune Cell Signaling, Molecular biology

Qualified Joint CSIR-UGC NET DECEMBER, 2017 (LIFE SCIENCES)., Qualified Joint CSIR-UGC NET JUNE, 2018 (LIFE SCIENCES)., Qualified VBRET-2018

• Das, S., Mukherjee, U., Biswas, S., Banerjee, S., Karmakar, S. and Maitra, S., 2024. Unravelling bisphenol A-induced hepatotoxicity: Insights into oxidative stress, inflammation, and energy dysregulation. Environmental Pollution, 362, p.124922.
• Das, S., Banerjee, S., Ghosh, S., Samanta, A., Maitra, S. Bisphenol A Induces Pro-Inflammatory M1 Macrophage Polarization via ROS-Mediated NF-κB/NLRP3 Activation and HIF-1α-Driven Metabolic Reprogramming. (Under review)
• Banerjee, S., Samanta, A., Ghosh, S., Das, S., Maitra, S. Acrylamide-induced neuroendocrine disruption in adult male zebrafish (Danio rerio): Mechanistic insights into locomotor, neuronal, and reproductive impairments (Accepted manuscript on 13.08.25, under pagination).
• Biswas, S., Ghosh, S., Das, S. and Maitra, S., 2021, December. Female reproduction: at the crossroads of endocrine disruptors and epigenetics. In Proceedings of the Zoological Society (Vol. 74, No. 4, pp. 532-545). New Delhi: Springer India.
• Tarai, S.K., Pan, A., Das, S., Bhaduri, R., Mandal, S., Maitra, S. and Moi, S.C., 2022. Anticancer property and normal cell toxicity profile of pyrrolidine-based platinum (II) complexes: Their DNA, BSA interaction, and molecular docking. Applied Organometallic Chemistry, 36(11), p.e6859.
• Saha, S., Das, S., Samanta, A., Maitra, S. and Sahoo, P., 2020. Prompt detection of endogenous hypochlorite (ClO−) in murine macrophages and zebrafish embryos facilitated by a distinctive chemodosimetric mode. Organic & Biomolecular Chemistry, 18(34), pp.6716-6723.
• Mukherjee, U., Das, S., Ghosh, S., & Maitra, S. (2024). Reproductive toxicity of bisphenol A, at environmentally relevant concentrations, on ovarian redox balance, maturational response, and intra-oocyte signalling events in Labeo bata. Science of The Total Environment, 906, 167415.
• Biswas, S., Ghosh, S., Samanta, A., Das, S., Mukherjee, U., & Maitra, S. (2020). Bisphenol A impairs reproductive fitness in zebrafish ovary: Potential involvement of oxidative/nitrosative stress, inflammatory and apoptotic mediators. Environmental Pollution, 267, 115692.
• Mukherjee, U., Samanta, A., Biswas, S., Das, S., Ghosh, S., Banerjee, S., & Maitra, S. (2022). Chronic exposure to nonylphenol induces oxidative stress and liver damage in male zebrafish (Danio rerio): Mechanistic insight into cellular energy sensors, lipid accumulation and immune modulation. Chemico-biological interactions, 351, 109762.
• Mukherjee, U., Samanta, A., Biswas, S., Das, S., Ghosh, S., Mandal, D. K., & Maitra, S. (2020). Bisphenol A-induced oxidative stress, hepatotoxicity and altered estrogen receptor expression in Labeo bata: impact on metabolic homeostasis and inflammatory response. Ecotoxicology and Environmental Safety, 202, 110944.
• Nath, P., Mukherjee, U., Biswas, S., Pal, S., Das, S., Ghosh, S., ... & Maitra, S. (2019). Expression of nitric oxide synthase (NOS) in Anabas testudineus ovary and participation of nitric oxide-cyclic GMP cascade in maintenance of meiotic arrest. Molecular and cellular endocrinology, 496, 110544.
• Biswas S., Mukherjee U., Ghosh S., Samanta A., Das S. and Maitra S.
• (2019) Connecting deregulated inflammation and apoptosis to ovarian follicular dynamics: missing link between endocrine disruption and compromised female fertility: In ISSRF Newsletter - Translational Research in Reproductive health, Issue 24, (Prof. N.K. Lohiya, Dr. Rupesh Kumar Srivastava, eds). ISSN: 2395-2806.
• Biswas S., Ghosh S., Mukherjee U., Samanta A., Das S. and Maitra S. (2021) Hormonally Active Agents: A Menace for Oogenesis and Fertility in Teleosts. In: Recent updates in molecular Endocrinology and Reproductive Physiology of Fish. (J. Sundaray et al., eds.). # Springer Nature Singapore Pte Ltd. 283-321. ISBN: 978-981-15-8369-8.
• Ghosh, S., Karmakar, S., Banerjee, S., Biswas, S., Mukherjee, U., Das, S., Samanta, A. and Maitra, S., 2025. Detrimental impacts of chronic bisphenol A (BPA) exposure on follicular signalling modulation and ovulatory competence in zebrafish (Danio rerio). Environmental Pollution, p.126779.

• Participated in 2nd Asian congress of Parasitology and 9th Asian conference on ciliate biology on 27-29 November ,2014
• Presented a poster in the two days’ workshop cum national seminar on“Trends in Modern Biology: Techniques and Applications” held in the Department of Zoology, Visva-Bharati, Santiniketan, West Bengal during March 23-24, 2019.
• Participated in the national seminar on Advancement of Biology in the 21st Century, held on February 28-29, 2020 in the Department of Zoology, Visva-Bharati, Santiniketan, West Bengal
• Presented an online poster in the “International Colloquium on Regulatory Mechanisms underlying Behaviour, Physiology and Development” organized by Department of Zoology, University of Delhi, during March 24-26, 2021 in Delhi, India.
• National Seminar on Recent Advances in Animal Science (RAASVB-2024), held on 07.03.2024-08.03.2024. Department of Zoology, Siksha Bhavana, Visva-Bharati, Santiniketan, West Bengal, India.
• Participated 7-days Technical Hands-On Workshop on Bioinformatics, organized by BDG Lifesciences (OPC) Pvt. Ltd. during August 3-9, 2020.
• Participated Technical Workshop on Advances in RNA-based Therapeutics: RNA World to Era of RNA Revolution, organized by Rapture Biotech International (P) Ltd., Biotechnology Company, on August 24, 2020.
• Extensive hands-on training on "Flow Cytometry" conducted by the Skill Development Centre in association with BD Biosciences and Beckman coulter during 27th february to 4 th March, 2023 in the University of Hyderabad.
• Workshop on Stem Cell Culture. Certificate No. BL25SCC13903, Date of Issuance: 24th Mar 2025
• One month workshop on Basic to advanced Bioinformatics, Genomics, AI and Machine Learning with the collaboration of nextgenhelper. March-April, 2025.
• EDUTECHLIFE Biological training with internship program on CRISPR/CAS-9 in association with MECHANICA, IIT MADRAS, April-May, 2025.
• Oral presentation on ICAEMRH, 2025 at Benaras Hindu University.

• Communications Biology, https://www.nature.com/commsbio/
• Ecotoxicology and environmental safety, https://www.sciencedirect.com/journal/ecotoxicology-and-environmental-safety
• Scientific Reports, https://www.nature.com/srep/
• International Journal Of Endocrinology, https://onlinelibrary.wiley.com/journal/1573
• Fish Physiology and Biochemistry., https://link.springer.com/journal/10695
• Environmental Geochemistry and Health., https://link.springer.com/journal/10653