Summary
Overview
Work History
Education
Skills
Certification
Publications
Accomplishments
Additional Information
Timeline
Generic

LEEMA GEORGE

Immuno-oncology, Cell and Gene Therapy
Bangalore

Summary

Results-driven professional with expertise in scientific research, analytical thinking, and problem-solving. Demonstrated ability to design and execute precise experiments, ensuring accurate data interpretation. Strong communicator, adept at conveying complex scientific concepts clearly in both written and verbal communication. Recognized as a collaborative team player, known for critical analysis, innovative insights, and fostering productive discussions. Committed to advancing scientific discoveries and therapeutic innovations through a meticulous and strategic approach.

Overview

14
14
years of professional experience
10
10
years of post-secondary education
1
1
Certification

Work History

Research Associate

Nkure Therapeutics Pvt Ltd
09.2023 - Current

Cell and Gene Therapy

Develop, review, and implement Standard Operating Procedures (SOPs)

Contribute to scientific research, data analysis, and innovation strategies to improve manufacturing efficiency and product quality.

Assistant Professor

St. Joseph's University
08.2021 - 08.2023

Research Scientist

Archeron Group
03.2021 - 08.2021

CAR-T cell immunotherapy

Assistant Professor

Jain University
12.2019 - 12.2020

Academic Support Specialist

Biotecnika Info Labs Pvt. Ltd
01.2019 - 05.2019

Research Associate

BIRAC
12.2017 - 12.2018

Biotechnology Ignition Grant (Ref No BIRAC/CCAMP0334/BIG-08/16), Vellore Institute of Technology

Research Associate

School of Bioscience and Technology, VIT
09.2013 - 09.2017

Project Intern

Indian Institute of Science
02.2013 - 04.2013

Title: Anti Cancer -screening of bioactive compounds produced by endophytic microorganisms

Guest Lecturer

St. Thomas College
07.2011 - 11.2011

Education

Ph.D. - Immunology

Vellore Institute of Tecchnology
Tamil Nadu
06.2013 - 07.2019

Master of Science - Biomedical Genetics

Vellore Institute of Technology
Tamil Nadu
07.2009 - 06.2011

Bachelor of Science - Botany

Mahatma Gandhi University
Kerala
06.2007 - 06.2009

Skills

Extensive experience in handling rodents (mice, rats) for preclinical research

Expertise in mammalian cell culture, including maintenance of diverse cell lines (RAW 2647, B16BL6, A549, HCT-15, MCF-7, HEK-293, CHO, and Vero)

Skilled in primary cell isolation and culture, including rat bone marrow-derived mesenchymal stem cells, mouse peritoneal macrophages, and mouse pancreatic acinar cells

Isolation of PBMCs, T cells, and NK cells for cell and gene therapy applications, including expansion, characterization, and genetic modifications for therapeutic use

Experienced in PBMC to iPSC reprogramming for stem cell research, regenerative medicine, and gene therapy applications

Proficient in cell viability and proliferation assays for evaluating cellular responses

Experienced in screening novel anti-cancer and anti-inflammatory compounds for therapeutic development

Skilled in molecular biology techniques, including PCR (standard and qRT-PCR), ELISA, SDS-PAGE, Western blotting, and cloning

Proficient in gene delivery techniques, including Lipofectamine- and CaCl₂-mediated transfection and electroporation

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Certification

Manickam, V., George, L., Tanny, A., Lochana, R., Velusamy, R. K., Kumar, M. M., & Tamizhselvi, R. (2018). Methods and Protocols for In Vitro Animal Nanotoxicity Evaluation: A Detailed Review. Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management, 285.

Publications

  • Brahadeeswaran S, Chitluri KK, George L, Manickam V, Emerson IA, Tamizhselvi R. Scopoletin: A Validated Protector against Cerulein-induced Acute Pancreatitis & Associated Lung Injury by Regulating PPAR-γ “A Multidimensional Approach”. Molecular Biotechnology. 2024 Dec 2:1-9.
  • Leema George, Tamizhselvi Ramasamy, Sirajudeen KNS, Venkatraman Manickam LPS- induced apoptosis is partially mediated by hydrogen sulphide in RAW 264.7 Murine Macrophages. Immunological Investigation 2019 Jan 28:1-15
  • George L, Tamizhselvi. (2018). Protective Effect of Scopoletin Against Cerulein- Induced Acute Pancreatitis and Associated Lung Injury in Mice. Pancreas May/Jun; 47(5):577- 585.
  • Mundekkad Deepa, Leema George, Bhavapriya, Chidambaram Ramalingam (2017). Induction of Apoptosis in HCT-15 and A549 Cell Lines by the Extracts of Excoecaria agallocha L. by the Downregulation of Ornithine Decarboxylase. Brazilian archives of biology and technology (DOI: 10.1590/1678-4324-2017160252)
  • George, L., Ramasamy, T., Manickam, V., Iyer, S. K., & Radhakrishnan, V. (2016). Novel phenanthridine (PHE-4i) derivative inhibits carrageenan-induced rat hind paw oedema through suppression of hydrogen sulfide. Inflammopharmacology 24(4), 173- 180.
  • Hussain, S., Tamizhselvi, R., George, L., & Manickam, V. (2016). Assessment of the role of noni (morinda citrifolia) juice for inducing osteoblast differentiation in isolated rat bone marrow derived mesenchymal stem cells. International journal of stem cells, 9(2), 221.
  • R. Bhavapriya, Leema George, R. Vidya, M. Venkatraman, R. Tamizhselvi and K. I. Sathiyanarayanan. (2015) Antimicrobial assay on synthetic phenanthridine derivatives. Journal of Indian Chemical society 92(6):854-856
  • George, L., Rajendran, B., Manickam, V., Ragothaman, A., Sirajudeen, K., & Tamizhselvi, R. (2014). Psidium guajava leaf extract modulates cytokine expression in lipopolysaccharide-activated primary mouse neutrophils thereby inhibiting NF-κB activity. International Journal of Biological & Pharmaceutical Research. 5(11), 870-875

Accomplishments

  • Council of Scientific & Industrial Research, National Eligibility Test (CSIR NET): All India Rank - 31
  • Graduate Aptitude Test in Engineering (GATE) (2013): All India Rank (AIR)-867, Percentile 93
  • TOEFL (2012)-score 95

Additional Information

  • Recognized reviewer of the journal “GENE” (ELSEVIER)


Timeline

Research Associate

Nkure Therapeutics Pvt Ltd
09.2023 - Current

Assistant Professor

St. Joseph's University
08.2021 - 08.2023

Research Scientist

Archeron Group
03.2021 - 08.2021

Assistant Professor

Jain University
12.2019 - 12.2020

Academic Support Specialist

Biotecnika Info Labs Pvt. Ltd
01.2019 - 05.2019

Research Associate

BIRAC
12.2017 - 12.2018

Research Associate

School of Bioscience and Technology, VIT
09.2013 - 09.2017

Ph.D. - Immunology

Vellore Institute of Tecchnology
06.2013 - 07.2019

Project Intern

Indian Institute of Science
02.2013 - 04.2013

Guest Lecturer

St. Thomas College
07.2011 - 11.2011

Master of Science - Biomedical Genetics

Vellore Institute of Technology
07.2009 - 06.2011

Bachelor of Science - Botany

Mahatma Gandhi University
06.2007 - 06.2009
LEEMA GEORGEImmuno-oncology, Cell and Gene Therapy