Manali Jain
Senior Research Fellow
Lucknow
Summary
Passionate about advancing biotechnology with a focus on stem cell research, biochemistry, and molecular biology. Seeking a dynamic career in cutting-edge R&D environments that emphasize innovation and teamwork. Skilled in project management, experimental design, and troubleshooting, with a strong commitment to translating scientific research into practical solutions.
Overview
6
6
years of post-secondary education
Work History
Senior Research Fellow
Sanjay Gandhi Post Graduate Institute of Medical Sciences
- Current
- Conducted studies on cardiac progenitor markers, transcription factors, and vascular markers using advanced techniques such as flow cytometry, real-time PCR, and immunocytochemistry
- Isolated and characterized exosomes and secretome derived from mesenchymal stem cells for therapeutic applications
- Developed an in-vitro ischemia-reperfusion injury model to simulate myocardial injury for experimental analysis
- Established an in-vivo myocardial injury model in SD rats to assess stem cell-based interventions
- Evaluated the therapeutic efficacy of both stem cell and cell-free therapies in in-vitro and in-vivo models of myocardial injury.
Junior Research Fellow
Sanjay Gandhi Post Graduate Institute of Medical Sciences
7 2024
- Assisted in a project evaluating the renogenic potential of amniotic fluid stem cells and their therapeutic efficacy in treating acute renal failure
- Characterized mesenchymal stem cells derived from rat amniotic fluid to assess their regenerative properties
- Conducted studies on renal progenitor markers, transcription factors, and renogenic markers using flow cytometry, real-time PCR, and immunocytochemistry
- Developed an in-vivo model of acute renal injury to investigate stem cell-based therapies
- Evaluated the therapeutic efficacy of stem cells in an in-vivo model of acute kidney injury.
Education
Ph.D. - Stem Cell Biology
SGPGIMS
Lucknow, India 04.2001 -
M.Sc. Biotechnology - undefined
SIU, Pune
01.2015 - 04.2017
B.Sc. Biotechnology - undefined
MU, Aligarh
01.2012 - 04.2015
Skills
Cell and Tissue Culture
DNA/RNA isolation
Exosome and protein extraction
Flow Cytometry
Immunocytochemistry
Microscopy
Stem Cell Technology
Tissue Engineering
Molecular Biology
Epigenetics
Biochemistry
Clinical Biochemistry
Genomics
Biostatistics
Communicational
Critical Thinking
Positive Attitude
Leadership
Mentoring Experience
Supervisor, Sanjay Gandhi Post Graduate Institute of Medical Sciences, 6 months, M.Sc. students
Languages
Hindi
English
Location
Lucknow, India
Awards
- Best Research Poster Presentation, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, unpublished, Cardioprotective effect of c-kitve amniotic fluid mesenchymal stem cells in an in-vitro model of myocardial ischemia-reperfusion injury
- Best Oral Presentation, Third World Congress on Cardiac Sciences, 01/30/22, Bengaluru, Karnataka, India, Advances In Cardiology: Research and Innovations, Comparison of Cardiomyogenic Potential of Amniotic Fluid Mesenchymal Stromal Cells Derived from Normal and Isolated Congenital Heart Defective Fetuses
Workshops/Training/Conferences
- 2nd International Webinar on Cardiology, Paris, France, 11/14/22 - 11/15/22, Amniotic Fluid Mesenchymal Stromal Cells Derived from Fetuses with Isolated Cardiac Defects Exhibit Decreased Proliferation rate and Cardiomyogenic Potential
- Dissertation under Dr. Soniya Nityanand, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Comparative Evaluation of Cardiomyogenic Properties of Amniotic Fluid Stem Cells and Bone Marrow Mesenchymal Stem Cells
- Training on Flow Cytometry, Indian Institute of Toxicology Research Centre-CSIR, Lucknow
- Training in Genomics, Institute of Biotechnology & Research Centre, Agra
- Workshop on Biotechnology and Its Future Scope, B. Lal Institute of Technology, Jaipur
- Workshop on Emerging Trends in Biomedical Sciences, Symbiosis School of Biomedical Science, Pune
Publications
- Amniotic Fluid Mesenchymal Stromal Cells Derived from Fetuses with Isolated Cardiac Defects Exhibit Decreased Proliferation and Cardiomyogenic Potential, Biology, 04/05/23, 12, 4, 55
- Comparison of the cardiomyogenic potency of human amniotic fluid and bone marrow mesenchymal stem cells, International Journal of Stem Cells, 11/30/19, 12, 3, 449-56
- Amniotic fluid stem cells ameliorate cisplatin-induced acute renal failure through induction of autophagy and inhibition of apoptosis, Stem cell research & therapy, 12/01/19, 10, 1, 1-6
Instrumentsexpertise
- Flow Cytometer
- Confocal Microscope
- Real Time PCR
- Electrophoresis
References
- Dr Soniya Nityanand, Vice Chancellor, King George's Medical University (KGMU), Lucknow, 226003, India, soniya_nityanand@yahoo.co.in
- Dr CP Chaturvedi, Additional Professor, Department of Stem Cell Research Centre, SGPGIMS, Lucknow, Chaturvedicp75rediffmail.com
Extracurricular Activities
Conducted a talk as an alumni on the topic, 'Experience, Fail, Learn, Act, Succeed, Repeat,' organized by Symbiosis School of Biological Sciences, Symbiosis International University, Pune. Prabhakar Degree in Kathak Dance form (Lucknow Gharana) PhD Representative for the Library Association Cultural head for Research Fellow Association in SGPGIMS, Lucknow
Disclaimer
I hereby declare that all the above facts are true to the best of my knowledge
Timeline
M.Sc. Biotechnology - undefined
SIU, Pune
01.2015 - 04.2017
B.Sc. Biotechnology - undefined
MU, Aligarh
01.2012 - 04.2015
Ph.D. - Stem Cell Biology
SGPGIMS
04.2001 -
Senior Research Fellow
Sanjay Gandhi Post Graduate Institute of Medical Sciences
- Current
Junior Research Fellow
Sanjay Gandhi Post Graduate Institute of Medical Sciences
7 2024